Dysfunctional mucociliary clearance in asthma and airway remodeling – New insights into an old topic
(2023) In Respiratory Medicine 218.- Abstract
Bronchial asthma is a heterogeneous respiratory condition characterized by chronic airway inflammation, airway hyperresponsiveness and airway structural changes (known as remodeling). The clinical symptoms can be evoked by (non)specific triggers, and their intensity varies over time. In the past, treatment was mainly focusing on symptoms’ alleviation; in contrast modern treatment strategies target the underlying inflammation, even during asymptomatic periods. Components of airway remodeling include epithelial cell shedding and dysfunction, goblet cell hyperplasia, subepithelial matrix protein deposition, fibrosis, neoangiogenesis, airway smooth muscle cell hypertrophy and hyperplasia. Among the other important, and frequently forgotten... (More)
Bronchial asthma is a heterogeneous respiratory condition characterized by chronic airway inflammation, airway hyperresponsiveness and airway structural changes (known as remodeling). The clinical symptoms can be evoked by (non)specific triggers, and their intensity varies over time. In the past, treatment was mainly focusing on symptoms’ alleviation; in contrast modern treatment strategies target the underlying inflammation, even during asymptomatic periods. Components of airway remodeling include epithelial cell shedding and dysfunction, goblet cell hyperplasia, subepithelial matrix protein deposition, fibrosis, neoangiogenesis, airway smooth muscle cell hypertrophy and hyperplasia. Among the other important, and frequently forgotten aspects of airway remodeling, also loss of epithelial barrier integrity, immune defects in anti-infectious defence and mucociliary clearance (MCC) dysfunction should be pointed out. Mucociliary clearance represents one of the most important defence airway mechanisms. Several studies in asthmatics demonstrated various dysfunctions in MCC – e.g., ciliated cells displaying intracellular disorientation, abnormal cilia and cytoplasmic blebs. Moreover, excessive mucus production and persistent cough are one of the well-recognized features of severe asthma and are also associated with defects in MCC. Damaged airway epithelium and impaired function of the ciliary cells leads to MCC dysfunction resulting in higher susceptibility to infection and inflammation. Therefore, new strategies aimed on restoring the remodeling changes and MCC dysfunction could present a new therapeutic approach for the management of asthma and other chronic respiratory diseases.
(Less)
- author
- Jesenak, Milos ; Durdik, Peter ; Oppova, Dasa ; Franova, Sona ; Diamant, Zuzana LU ; Golebski, Kornel ; Banovcin, Peter ; Vojtkova, Jarmila and Novakova, Elena
- organization
- publishing date
- 2023-11
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Airway defence mechanisms, Airway remodeling, Bronchial asthma, Chronic inflammation, Epithelial dysfunction, Mucociliary clearance
- in
- Respiratory Medicine
- volume
- 218
- article number
- 107372
- publisher
- Elsevier
- external identifiers
-
- pmid:37516275
- scopus:85168748193
- ISSN
- 0954-6111
- DOI
- 10.1016/j.rmed.2023.107372
- language
- English
- LU publication?
- yes
- id
- 2c0dddf3-f3c2-4fa5-be99-2f5b73f343ed
- date added to LUP
- 2023-10-24 15:38:02
- date last changed
- 2024-04-19 02:50:59
@article{2c0dddf3-f3c2-4fa5-be99-2f5b73f343ed,
abstract = {{<p>Bronchial asthma is a heterogeneous respiratory condition characterized by chronic airway inflammation, airway hyperresponsiveness and airway structural changes (known as remodeling). The clinical symptoms can be evoked by (non)specific triggers, and their intensity varies over time. In the past, treatment was mainly focusing on symptoms’ alleviation; in contrast modern treatment strategies target the underlying inflammation, even during asymptomatic periods. Components of airway remodeling include epithelial cell shedding and dysfunction, goblet cell hyperplasia, subepithelial matrix protein deposition, fibrosis, neoangiogenesis, airway smooth muscle cell hypertrophy and hyperplasia. Among the other important, and frequently forgotten aspects of airway remodeling, also loss of epithelial barrier integrity, immune defects in anti-infectious defence and mucociliary clearance (MCC) dysfunction should be pointed out. Mucociliary clearance represents one of the most important defence airway mechanisms. Several studies in asthmatics demonstrated various dysfunctions in MCC – e.g., ciliated cells displaying intracellular disorientation, abnormal cilia and cytoplasmic blebs. Moreover, excessive mucus production and persistent cough are one of the well-recognized features of severe asthma and are also associated with defects in MCC. Damaged airway epithelium and impaired function of the ciliary cells leads to MCC dysfunction resulting in higher susceptibility to infection and inflammation. Therefore, new strategies aimed on restoring the remodeling changes and MCC dysfunction could present a new therapeutic approach for the management of asthma and other chronic respiratory diseases.</p>}},
author = {{Jesenak, Milos and Durdik, Peter and Oppova, Dasa and Franova, Sona and Diamant, Zuzana and Golebski, Kornel and Banovcin, Peter and Vojtkova, Jarmila and Novakova, Elena}},
issn = {{0954-6111}},
keywords = {{Airway defence mechanisms; Airway remodeling; Bronchial asthma; Chronic inflammation; Epithelial dysfunction; Mucociliary clearance}},
language = {{eng}},
publisher = {{Elsevier}},
series = {{Respiratory Medicine}},
title = {{Dysfunctional mucociliary clearance in asthma and airway remodeling – New insights into an old topic}},
url = {{http://dx.doi.org/10.1016/j.rmed.2023.107372}},
doi = {{10.1016/j.rmed.2023.107372}},
volume = {{218}},
year = {{2023}},
}