Prevalence of impaired renal function among childless men as compared to fathers : a population-based study
(2024) In Scientific Reports 14(1).- Abstract
Male reproductive impairment has been linked with an increased risk of numerous non-communicable diseases. Yet, epidemiological data on renal disease among subfertile men is scarce. Therefore, by using male childlessness as a proxy for male infertility, we aimed to investigate its association with renal function. Data was sourced from a population-based cohort including 22,444 men. After exclusion of men aged < 45 years (n = 10,842), the remaining men were divided into two groups: these being childless (n = 5494) and fathers (n = 6108). Logistic regression was applied to explore the association between male childlessness and renal impairment. Childless men as compared to fathers, were more likely to have an estimated-glomerular... (More)
Male reproductive impairment has been linked with an increased risk of numerous non-communicable diseases. Yet, epidemiological data on renal disease among subfertile men is scarce. Therefore, by using male childlessness as a proxy for male infertility, we aimed to investigate its association with renal function. Data was sourced from a population-based cohort including 22,444 men. After exclusion of men aged < 45 years (n = 10,842), the remaining men were divided into two groups: these being childless (n = 5494) and fathers (n = 6108). Logistic regression was applied to explore the association between male childlessness and renal impairment. Childless men as compared to fathers, were more likely to have an estimated-glomerular filtration rate < 60 ml/min/1.73m2 (OR 1.36, 95 CI 1.08–1.70; p = 0.008). After adjustment for age, marital status, smoking habits, diabetes, hypertension and other components of metabolic syndrome, childless men were also more likely to have dipstick proteinuria (OR 1.85, 95 CI 1.16–2.95; p = 0.01). With the growing panorama of disease associated with male reproductive impairment, men with fertility issues may constitute a target population with potential benefit from closer follow-up of their renal function.
(Less)
- author
- Kitlinski, Michael LU ; Giwercman, Aleksander LU ; Christensson, Anders LU ; Nilsson, Peter M. LU and Elenkov, Angel LU
- organization
- publishing date
- 2024-04
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Scientific Reports
- volume
- 14
- issue
- 1
- article number
- 7720
- publisher
- Nature Publishing Group
- external identifiers
-
- pmid:38565688
- scopus:85189146107
- ISSN
- 2045-2322
- DOI
- 10.1038/s41598-024-58479-9
- language
- English
- LU publication?
- yes
- id
- 2c1d0857-8aa1-4563-8577-18bd71c29b7f
- date added to LUP
- 2024-04-18 14:40:46
- date last changed
- 2024-04-24 12:43:08
@article{2c1d0857-8aa1-4563-8577-18bd71c29b7f,
abstract = {{<p>Male reproductive impairment has been linked with an increased risk of numerous non-communicable diseases. Yet, epidemiological data on renal disease among subfertile men is scarce. Therefore, by using male childlessness as a proxy for male infertility, we aimed to investigate its association with renal function. Data was sourced from a population-based cohort including 22,444 men. After exclusion of men aged < 45 years (n = 10,842), the remaining men were divided into two groups: these being childless (n = 5494) and fathers (n = 6108). Logistic regression was applied to explore the association between male childlessness and renal impairment. Childless men as compared to fathers, were more likely to have an estimated-glomerular filtration rate < 60 ml/min/1.73m<sup>2</sup> (OR 1.36, 95 CI 1.08–1.70; p = 0.008). After adjustment for age, marital status, smoking habits, diabetes, hypertension and other components of metabolic syndrome, childless men were also more likely to have dipstick proteinuria (OR 1.85, 95 CI 1.16–2.95; p = 0.01). With the growing panorama of disease associated with male reproductive impairment, men with fertility issues may constitute a target population with potential benefit from closer follow-up of their renal function.</p>}},
author = {{Kitlinski, Michael and Giwercman, Aleksander and Christensson, Anders and Nilsson, Peter M. and Elenkov, Angel}},
issn = {{2045-2322}},
language = {{eng}},
number = {{1}},
publisher = {{Nature Publishing Group}},
series = {{Scientific Reports}},
title = {{Prevalence of impaired renal function among childless men as compared to fathers : a population-based study}},
url = {{http://dx.doi.org/10.1038/s41598-024-58479-9}},
doi = {{10.1038/s41598-024-58479-9}},
volume = {{14}},
year = {{2024}},
}