The red blood cell count and the erythrocyte sedimentation rate in the diagnosis of polycythaemia vera
Nersesjan, Vardan ; Zervides, Kristoffer A LU
; Sørensen, Anders L
; Kjaer, Lasse
; Skov, Vibe
and Hasselbalch, Hans C
(2019)
In European Journal of Haematology
p.1-9
- Abstract
BACKGROUND: Iron deficiency in polycythaemia vera (PV) may impact the validity of the haematocrit (HCT), since HCT is red blood cell count (RBC) × mean corpuscular volume (MCV).
OBJECTIVES: To investigate (a) the effect of microcytosis on HCT, (b) the erythrocyte sedimentation rate (ESR) as a possible additional diagnostic marker for PV.
MATERIAL AND METHODS: This study included 182 subjects: 39 with PV, 27 with essential thrombocythemia (ET) and 116 suspected of myeloproliferative neoplasm (MPN) with a secondary cause for either thrombocytosis or erythrocytosis.
RESULTS: Patients with PV had significantly lower ratio of MCV and serum ferritin compared to MPN suspects. A good correlation of RBC versus HCT was found for... (More)
BACKGROUND: Iron deficiency in polycythaemia vera (PV) may impact the validity of the haematocrit (HCT), since HCT is red blood cell count (RBC) × mean corpuscular volume (MCV).
OBJECTIVES: To investigate (a) the effect of microcytosis on HCT, (b) the erythrocyte sedimentation rate (ESR) as a possible additional diagnostic marker for PV.
MATERIAL AND METHODS: This study included 182 subjects: 39 with PV, 27 with essential thrombocythemia (ET) and 116 suspected of myeloproliferative neoplasm (MPN) with a secondary cause for either thrombocytosis or erythrocytosis.
RESULTS: Patients with PV had significantly lower ratio of MCV and serum ferritin compared to MPN suspects. A good correlation of RBC versus HCT was found for PV and MPN subjects when individuals with microcytosis were excluded (R2 = .87 in PV and R2 = .82 in MPN suspects). We found a specificity of 98% and a sensitivity of 37% for ESR <2 mm in the diagnosis of PV.
CONCLUSION: The RBC may more precisely reflect the total red cell mass and accordingly the hypercoagulable state of the PV patient, which is integrated in the ESR. A combination of RBC and ESR is proposed as a novel tool to substitute the Hb concentration and the HCT in the diagnosis of PV.
(Less)
- author
- Nersesjan, Vardan
; Zervides, Kristoffer A
LU
; Sørensen, Anders L
; Kjaer, Lasse
; Skov, Vibe
and Hasselbalch, Hans C
- organization
- publishing date
- 2019-10-04
- type
- Contribution to journal
- publication status
- published
- subject
- in
- European Journal of Haematology
- pages
- 1 - 9
- publisher
- Wiley-Blackwell
- external identifiers
-
- scopus:85074428286
- pmid:31584701
- ISSN
- 1600-0609
- DOI
- 10.1111/ejh.13334
- language
- English
- LU publication?
- yes
- additional info
- © 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
- id
- 2c50a7a4-3225-4f91-9dbd-73eea7a57b1a
- date added to LUP
- 2019-11-26 14:34:08
- date last changed
- 2024-05-15 02:40:39
@article{2c50a7a4-3225-4f91-9dbd-73eea7a57b1a,
abstract = {{<p>BACKGROUND: Iron deficiency in polycythaemia vera (PV) may impact the validity of the haematocrit (HCT), since HCT is red blood cell count (RBC) × mean corpuscular volume (MCV).</p><p>OBJECTIVES: To investigate (a) the effect of microcytosis on HCT, (b) the erythrocyte sedimentation rate (ESR) as a possible additional diagnostic marker for PV.</p><p>MATERIAL AND METHODS: This study included 182 subjects: 39 with PV, 27 with essential thrombocythemia (ET) and 116 suspected of myeloproliferative neoplasm (MPN) with a secondary cause for either thrombocytosis or erythrocytosis.</p><p>RESULTS: Patients with PV had significantly lower ratio of MCV and serum ferritin compared to MPN suspects. A good correlation of RBC versus HCT was found for PV and MPN subjects when individuals with microcytosis were excluded (R2 = .87 in PV and R2 = .82 in MPN suspects). We found a specificity of 98% and a sensitivity of 37% for ESR <2 mm in the diagnosis of PV.</p><p>CONCLUSION: The RBC may more precisely reflect the total red cell mass and accordingly the hypercoagulable state of the PV patient, which is integrated in the ESR. A combination of RBC and ESR is proposed as a novel tool to substitute the Hb concentration and the HCT in the diagnosis of PV.</p>}},
author = {{Nersesjan, Vardan and Zervides, Kristoffer A and Sørensen, Anders L and Kjaer, Lasse and Skov, Vibe and Hasselbalch, Hans C}},
issn = {{1600-0609}},
language = {{eng}},
month = {{10}},
pages = {{1--9}},
publisher = {{Wiley-Blackwell}},
series = {{European Journal of Haematology}},
title = {{The red blood cell count and the erythrocyte sedimentation rate in the diagnosis of polycythaemia vera}},
url = {{http://dx.doi.org/10.1111/ejh.13334}},
doi = {{10.1111/ejh.13334}},
year = {{2019}},
}