The association between water intake and future cardiometabolic disease outcomes in the Malmö Diet and Cancer cardiovascular cohort
(2024) In PLoS ONE 19(1). p.0296778-0296778- Abstract
The aim of this study was to explore the longitudinal association between reported baseline water intake and incidence of coronary artery disease (CAD) and type 2 diabetes in the Malmö Diet and Cancer Cohort (n = 25,369). Using cox proportional hazards models, we separately modelled the effect of plain and total (all water, including from food) water on CAD and type 2 diabetes risk, whilst adjusting for age, sex, diet collection method, season, smoking status, alcohol intake, physical activity, education level, energy intake, energy misreporting, body mass index, hypertension, lipid lowering medication, apolipoprotein A, apolipoprotein B, and dietary variables. Sensitivity analyses were run to assess validity. After adjustment, no... (More)
The aim of this study was to explore the longitudinal association between reported baseline water intake and incidence of coronary artery disease (CAD) and type 2 diabetes in the Malmö Diet and Cancer Cohort (n = 25,369). Using cox proportional hazards models, we separately modelled the effect of plain and total (all water, including from food) water on CAD and type 2 diabetes risk, whilst adjusting for age, sex, diet collection method, season, smoking status, alcohol intake, physical activity, education level, energy intake, energy misreporting, body mass index, hypertension, lipid lowering medication, apolipoprotein A, apolipoprotein B, and dietary variables. Sensitivity analyses were run to assess validity. After adjustment, no association was found between tertiles of plain or total water intake and type 2 diabetes risk. For CAD, no association was found comparing moderate to low intake tertiles from plain or total water, however, risk of CAD increased by 12% (95% CI 1.03, 1.21) when comparing high to low intake tertiles of plain water, and by 17% (95% CI 1.07, 1.27) for high versus low tertiles of total water. Sensitivity analyses were largely in agreement. Overall, baseline water intake was not associated with future type 2 diabetes risk, whilst CAD risk was higher with higher water intakes. Our findings are discordant with prevailing literature suggesting higher water intakes should reduce cardiometabolic risk. These findings may be an artefact of limitations within the study, but future research is needed to understand if there is a causal underpinning.
(Less)
- author
- Carroll, Harriet A. LU ; Ericson, Ulrika LU ; Ottosson, Filip LU ; Enhörning, Sofia LU and Melander, Olle LU
- organization
-
- Cardiovascular Research - Hypertension (research group)
- Diabetes - Cardiovascular Disease (research group)
- EpiHealth: Epidemiology for Health
- EXODIAB: Excellence of Diabetes Research in Sweden
- Perinatal and cardiovascular epidemiology (research group)
- MultiPark: Multidisciplinary research focused on Parkinson´s disease
- publishing date
- 2024
- type
- Contribution to journal
- publication status
- published
- subject
- in
- PLoS ONE
- volume
- 19
- issue
- 1
- pages
- 0296778 - 0296778
- publisher
- Public Library of Science (PLoS)
- external identifiers
-
- pmid:38241317
- scopus:85182869708
- ISSN
- 1932-6203
- DOI
- 10.1371/journal.pone.0296778
- language
- English
- LU publication?
- yes
- id
- 2c8e4fe8-85c1-424d-9c84-4b3f5dea04fb
- date added to LUP
- 2024-02-23 11:12:42
- date last changed
- 2024-04-22 19:44:54
@article{2c8e4fe8-85c1-424d-9c84-4b3f5dea04fb, abstract = {{<p>The aim of this study was to explore the longitudinal association between reported baseline water intake and incidence of coronary artery disease (CAD) and type 2 diabetes in the Malmö Diet and Cancer Cohort (n = 25,369). Using cox proportional hazards models, we separately modelled the effect of plain and total (all water, including from food) water on CAD and type 2 diabetes risk, whilst adjusting for age, sex, diet collection method, season, smoking status, alcohol intake, physical activity, education level, energy intake, energy misreporting, body mass index, hypertension, lipid lowering medication, apolipoprotein A, apolipoprotein B, and dietary variables. Sensitivity analyses were run to assess validity. After adjustment, no association was found between tertiles of plain or total water intake and type 2 diabetes risk. For CAD, no association was found comparing moderate to low intake tertiles from plain or total water, however, risk of CAD increased by 12% (95% CI 1.03, 1.21) when comparing high to low intake tertiles of plain water, and by 17% (95% CI 1.07, 1.27) for high versus low tertiles of total water. Sensitivity analyses were largely in agreement. Overall, baseline water intake was not associated with future type 2 diabetes risk, whilst CAD risk was higher with higher water intakes. Our findings are discordant with prevailing literature suggesting higher water intakes should reduce cardiometabolic risk. These findings may be an artefact of limitations within the study, but future research is needed to understand if there is a causal underpinning.</p>}}, author = {{Carroll, Harriet A. and Ericson, Ulrika and Ottosson, Filip and Enhörning, Sofia and Melander, Olle}}, issn = {{1932-6203}}, language = {{eng}}, number = {{1}}, pages = {{0296778--0296778}}, publisher = {{Public Library of Science (PLoS)}}, series = {{PLoS ONE}}, title = {{The association between water intake and future cardiometabolic disease outcomes in the Malmö Diet and Cancer cardiovascular cohort}}, url = {{http://dx.doi.org/10.1371/journal.pone.0296778}}, doi = {{10.1371/journal.pone.0296778}}, volume = {{19}}, year = {{2024}}, }