Convection-enhanced delivery of carboplatin PLGA nanoparticles for the treatment of glioblastoma
(2015) In PLoS ONE 10(7).- Abstract
We currently use Convection-Enhanced Delivery (CED) of the platinum-based drug, carboplatin as a novel treatment strategy for high grade glioblastoma in adults and children. Although initial results show promise, carboplatin is not specifically toxic to tumour cells and has been associated with neurotoxicity at high infused concentrations in pre-clinical studies. Our treatment strategy requires intermittent infusions due to rapid clearance of carboplatin from the brain. In this study, carboplatin was encapsulated in lactic acid-glycolic acid copolymer (PLGA) to develop a novel drug delivery system. Neuronal and tumour cytotoxicity were assessed in primary neuronal and glioblastoma cell cultures. Distribution, tissue clearance and... (More)
We currently use Convection-Enhanced Delivery (CED) of the platinum-based drug, carboplatin as a novel treatment strategy for high grade glioblastoma in adults and children. Although initial results show promise, carboplatin is not specifically toxic to tumour cells and has been associated with neurotoxicity at high infused concentrations in pre-clinical studies. Our treatment strategy requires intermittent infusions due to rapid clearance of carboplatin from the brain. In this study, carboplatin was encapsulated in lactic acid-glycolic acid copolymer (PLGA) to develop a novel drug delivery system. Neuronal and tumour cytotoxicity were assessed in primary neuronal and glioblastoma cell cultures. Distribution, tissue clearance and toxicity of carboplatin nanoparticles following CED was assessed in rat and porcine models. Carboplatin nanoparticles conferred greater tumour cytotoxicity, reduced neuronal toxicity and prolonged tissue half-life. In conclusion, this drug delivery system has the potential to improve the prognosis for patients with glioblastomas.
(Less)
- author
- Arshad, Azeem
; Yang, B.
; Bienemann, Alison S.
; Barua, Neil U.
; Wyatt, Marcella J.
; Woolley, Max
; Johnson, Dave E.
; Edler, Karen J.
LU
and Gill, Steven S.
- publishing date
- 2015-07-17
- type
- Contribution to journal
- publication status
- published
- in
- PLoS ONE
- volume
- 10
- issue
- 7
- article number
- e0132266
- publisher
- Public Library of Science (PLoS)
- external identifiers
-
- scopus:84940871819
- pmid:26186224
- ISSN
- 1932-6203
- DOI
- 10.1371/journal.pone.0132266
- language
- English
- LU publication?
- no
- additional info
- Publisher Copyright: © 2015 Arshad et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- id
- 2ce76b30-bc59-4043-bd45-0813d37728af
- date added to LUP
- 2023-03-29 11:46:58
- date last changed
- 2024-06-14 00:44:17
@article{2ce76b30-bc59-4043-bd45-0813d37728af, abstract = {{<p>We currently use Convection-Enhanced Delivery (CED) of the platinum-based drug, carboplatin as a novel treatment strategy for high grade glioblastoma in adults and children. Although initial results show promise, carboplatin is not specifically toxic to tumour cells and has been associated with neurotoxicity at high infused concentrations in pre-clinical studies. Our treatment strategy requires intermittent infusions due to rapid clearance of carboplatin from the brain. In this study, carboplatin was encapsulated in lactic acid-glycolic acid copolymer (PLGA) to develop a novel drug delivery system. Neuronal and tumour cytotoxicity were assessed in primary neuronal and glioblastoma cell cultures. Distribution, tissue clearance and toxicity of carboplatin nanoparticles following CED was assessed in rat and porcine models. Carboplatin nanoparticles conferred greater tumour cytotoxicity, reduced neuronal toxicity and prolonged tissue half-life. In conclusion, this drug delivery system has the potential to improve the prognosis for patients with glioblastomas.</p>}}, author = {{Arshad, Azeem and Yang, B. and Bienemann, Alison S. and Barua, Neil U. and Wyatt, Marcella J. and Woolley, Max and Johnson, Dave E. and Edler, Karen J. and Gill, Steven S.}}, issn = {{1932-6203}}, language = {{eng}}, month = {{07}}, number = {{7}}, publisher = {{Public Library of Science (PLoS)}}, series = {{PLoS ONE}}, title = {{Convection-enhanced delivery of carboplatin PLGA nanoparticles for the treatment of glioblastoma}}, url = {{http://dx.doi.org/10.1371/journal.pone.0132266}}, doi = {{10.1371/journal.pone.0132266}}, volume = {{10}}, year = {{2015}}, }