Chlamydial contribution to anaerobic metabolism during eukaryotic evolution
Stairs, Courtney W LU
; Dharamshi, Jennah E
; Tamarit, Daniel
; Eme, Laura
; Jørgensen, Steffen L
; Spang, Anja
and Ettema, Thijs J G
(2020)
In Science Advances
6(35).
- Abstract
The origin of eukaryotes is a major open question in evolutionary biology. Multiple hypotheses posit that eukaryotes likely evolved from a syntrophic relationship between an archaeon and an alphaproteobacterium based on H2 exchange. However, there are no strong indications that modern eukaryotic H2 metabolism originated from archaea or alphaproteobacteria. Here, we present evidence for the origin of H2 metabolism genes in eukaryotes from an ancestor of the Anoxychlamydiales-a group of anaerobic chlamydiae, newly described here, from marine sediments. Among Chlamydiae, these bacteria uniquely encode genes for H2 metabolism and other anaerobiosis-associated pathways. Phylogenetic analyses of several components of H2 metabolism reveal that... (More)
The origin of eukaryotes is a major open question in evolutionary biology. Multiple hypotheses posit that eukaryotes likely evolved from a syntrophic relationship between an archaeon and an alphaproteobacterium based on H2 exchange. However, there are no strong indications that modern eukaryotic H2 metabolism originated from archaea or alphaproteobacteria. Here, we present evidence for the origin of H2 metabolism genes in eukaryotes from an ancestor of the Anoxychlamydiales-a group of anaerobic chlamydiae, newly described here, from marine sediments. Among Chlamydiae, these bacteria uniquely encode genes for H2 metabolism and other anaerobiosis-associated pathways. Phylogenetic analyses of several components of H2 metabolism reveal that Anoxychlamydiales homologs are the closest relatives to eukaryotic sequences. We propose that an ancestor of the Anoxychlamydiales contributed these key genes during the evolution of eukaryotes, supporting a mosaic evolutionary origin of eukaryotic metabolism.
(Less)
- author
- Stairs, Courtney W
LU
; Dharamshi, Jennah E
; Tamarit, Daniel
; Eme, Laura
; Jørgensen, Steffen L
; Spang, Anja
and Ettema, Thijs J G
- publishing date
- 2020-08
- type
- Contribution to journal
- publication status
- published
- in
- Science Advances
- volume
- 6
- issue
- 35
- article number
- eabb7258
- pages
- 8 pages
- publisher
- American Association for the Advancement of Science (AAAS)
- external identifiers
-
- scopus:85090872636
- pmid:32923644
- ISSN
- 2375-2548
- DOI
- 10.1126/sciadv.abb7258
- language
- English
- LU publication?
- no
- additional info
- Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).
- id
- 2d02c970-6b2c-41ba-9658-fcb0322b95b3
- date added to LUP
- 2020-10-21 11:06:39
- date last changed
- 2024-04-17 16:56:02
@article{2d02c970-6b2c-41ba-9658-fcb0322b95b3,
abstract = {{<p>The origin of eukaryotes is a major open question in evolutionary biology. Multiple hypotheses posit that eukaryotes likely evolved from a syntrophic relationship between an archaeon and an alphaproteobacterium based on H2 exchange. However, there are no strong indications that modern eukaryotic H2 metabolism originated from archaea or alphaproteobacteria. Here, we present evidence for the origin of H2 metabolism genes in eukaryotes from an ancestor of the Anoxychlamydiales-a group of anaerobic chlamydiae, newly described here, from marine sediments. Among Chlamydiae, these bacteria uniquely encode genes for H2 metabolism and other anaerobiosis-associated pathways. Phylogenetic analyses of several components of H2 metabolism reveal that Anoxychlamydiales homologs are the closest relatives to eukaryotic sequences. We propose that an ancestor of the Anoxychlamydiales contributed these key genes during the evolution of eukaryotes, supporting a mosaic evolutionary origin of eukaryotic metabolism.</p>}},
author = {{Stairs, Courtney W and Dharamshi, Jennah E and Tamarit, Daniel and Eme, Laura and Jørgensen, Steffen L and Spang, Anja and Ettema, Thijs J G}},
issn = {{2375-2548}},
language = {{eng}},
number = {{35}},
publisher = {{American Association for the Advancement of Science (AAAS)}},
series = {{Science Advances}},
title = {{Chlamydial contribution to anaerobic metabolism during eukaryotic evolution}},
url = {{http://dx.doi.org/10.1126/sciadv.abb7258}},
doi = {{10.1126/sciadv.abb7258}},
volume = {{6}},
year = {{2020}},
}