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EPOS2020/EUFOREA expert opinion on defining disease states and therapeutic goals in CRSwNP

Fokkens, W. J. ; De Corso, E. ; Backer, V. ; Bernal-Sprekelsen, M. ; Bjermer, L. LU ; von Buchwald, C. ; Chaker, A. ; Diamant, Z. LU ; Gevaert, P. and Han, J. , et al. (2024) In Rhinology 62(3). p.287-298
Abstract

Severe chronic rhinosinusitis with nasal polyps (CRSwNP), a form of diffuse bilateral (usually type 2) CRS, is a debilitating disease with a significant impact on quality of life (QoL). With novel knowledge and treatment options becoming available, there is a growing need to update or revise key definitions to enable communication across different specialties dealing with CRS, and to agree on novel goals of care in CRSwNP. The European Forum for Research and Education in Allergy and Airway diseases (EUFOREA) and EPOS expert members discussed how to measure treatment responses and set new treatment goals for CRSwNP. In this paper a consensus on a list of definitions related to CRSwNP is provided: control, remission, cure,... (More)

Severe chronic rhinosinusitis with nasal polyps (CRSwNP), a form of diffuse bilateral (usually type 2) CRS, is a debilitating disease with a significant impact on quality of life (QoL). With novel knowledge and treatment options becoming available, there is a growing need to update or revise key definitions to enable communication across different specialties dealing with CRS, and to agree on novel goals of care in CRSwNP. The European Forum for Research and Education in Allergy and Airway diseases (EUFOREA) and EPOS expert members discussed how to measure treatment responses and set new treatment goals for CRSwNP. In this paper a consensus on a list of definitions related to CRSwNP is provided: control, remission, cure, recurrence/exacerbation, treatable traits, remodeling, progression, and disease modification. By providing these definitions, the involved experts hope to improve communication between all stakeholders involved in CRSwNP treatment for use in routine care, basic and clinical research and international guidelines aimed to harmonize and optimize standard of care of patients with CRSwNP in the future.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Rhinology
volume
62
issue
3
pages
12 pages
publisher
University Hospital Utrecht
external identifiers
  • pmid:38217529
  • scopus:85193728002
ISSN
0300-0729
DOI
10.4193/Rhin23.415
language
English
LU publication?
yes
id
2d0937c1-a827-4e35-aa2d-7a78cc6ebb66
date added to LUP
2025-01-10 13:57:48
date last changed
2025-06-28 04:45:02
@article{2d0937c1-a827-4e35-aa2d-7a78cc6ebb66,
  abstract     = {{<p>Severe chronic rhinosinusitis with nasal polyps (CRSwNP), a form of diffuse bilateral (usually type 2) CRS, is a debilitating disease with a significant impact on quality of life (QoL). With novel knowledge and treatment options becoming available, there is a growing need to update or revise key definitions to enable communication across different specialties dealing with CRS, and to agree on novel goals of care in CRSwNP. The European Forum for Research and Education in Allergy and Airway diseases (EUFOREA) and EPOS expert members discussed how to measure treatment responses and set new treatment goals for CRSwNP. In this paper a consensus on a list of definitions related to CRSwNP is provided: control, remission, cure, recurrence/exacerbation, treatable traits, remodeling, progression, and disease modification. By providing these definitions, the involved experts hope to improve communication between all stakeholders involved in CRSwNP treatment for use in routine care, basic and clinical research and international guidelines aimed to harmonize and optimize standard of care of patients with CRSwNP in the future.</p>}},
  author       = {{Fokkens, W. J. and De Corso, E. and Backer, V. and Bernal-Sprekelsen, M. and Bjermer, L. and von Buchwald, C. and Chaker, A. and Diamant, Z. and Gevaert, P. and Han, J. and Hopkins, C. and Hox, V. and Klimek, L. and Lund, V. J. and Lee, S. and Luong, A. and Mullol, J. and Peters, A. and Pfaar, O. and Reitsma, S. and Toppila-Salmi, S. and Scadding, G. K. and Sedaghat, A. R. and Viskens, A. S. and Wagenmann, M. and Hellings, P. W.}},
  issn         = {{0300-0729}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{287--298}},
  publisher    = {{University Hospital Utrecht}},
  series       = {{Rhinology}},
  title        = {{EPOS2020/EUFOREA expert opinion on defining disease states and therapeutic goals in CRSwNP}},
  url          = {{http://dx.doi.org/10.4193/Rhin23.415}},
  doi          = {{10.4193/Rhin23.415}},
  volume       = {{62}},
  year         = {{2024}},
}