Decreased weight gain in BB rats before the clinical onset of insulin-dependent diabetes
Markholst, Helle ; Eastman, Susan ; Wilson, Deborah ; Fisher, Lloyd and Lernmark, Åke LU
(1993)
In Diabetes Research and Clinical Practice
21(1).
p.31-38
- Abstract
Inbred specific pathogen-free diabetes-prone (DP) and diabetes-resistant (DR) BB rats were crossed to produce F1 and intercrossed to produce F2 rats. Diabetes segregates in these crosses as a recessive trait on rat chromosome 4. The weight gain of genetically diabetes-prone rats born to F1 healthy parents was studied to avoid effects of maternal diabetes. The weight gain of the F2 rats was initially not different from the F1 parents. The F2 rats later developing diabetes grew in parallel with their non-affected siblings up until the last 9 days before onset. During these 9 days they showed a decreased weight gain compared to their healthy litter-mates regardless of age.... (More)
Inbred specific pathogen-free diabetes-prone (DP) and diabetes-resistant (DR) BB rats were crossed to produce F1 and intercrossed to produce F2 rats. Diabetes segregates in these crosses as a recessive trait on rat chromosome 4. The weight gain of genetically diabetes-prone rats born to F1 healthy parents was studied to avoid effects of maternal diabetes. The weight gain of the F2 rats was initially not different from the F1 parents. The F2 rats later developing diabetes grew in parallel with their non-affected siblings up until the last 9 days before onset. During these 9 days they showed a decreased weight gain compared to their healthy litter-mates regardless of age. We conclude that decreased weight gain precedes the abrupt clinical onset of diabetes in BB rats and that it may be due to processes associated with the selective loss of β cells.
(Less)
- author
- Markholst, Helle
; Eastman, Susan
; Wilson, Deborah
; Fisher, Lloyd
and Lernmark, Åke
LU
- publishing date
- 1993-01-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Body weight, Growth velocity, Prediabetes, Type 1 diabetes
- in
- Diabetes Research and Clinical Practice
- volume
- 21
- issue
- 1
- pages
- 8 pages
- publisher
- Elsevier
- external identifiers
-
- scopus:0027361142
- pmid:8253019
- ISSN
- 0168-8227
- DOI
- 10.1016/0168-8227(93)90094-L
- language
- English
- LU publication?
- no
- id
- 2d0d1abc-54c9-43b9-9fd5-cac1fe73be48
- date added to LUP
- 2019-09-11 09:29:00
- date last changed
- 2024-03-13 08:26:28
@article{2d0d1abc-54c9-43b9-9fd5-cac1fe73be48,
abstract = {{<p>Inbred specific pathogen-free diabetes-prone (DP) and diabetes-resistant (DR) BB rats were crossed to produce F<sub>1</sub> and intercrossed to produce F<sub>2</sub> rats. Diabetes segregates in these crosses as a recessive trait on rat chromosome 4. The weight gain of genetically diabetes-prone rats born to F<sub>1</sub> healthy parents was studied to avoid effects of maternal diabetes. The weight gain of the F<sub>2</sub> rats was initially not different from the F<sub>1</sub> parents. The F<sub>2</sub> rats later developing diabetes grew in parallel with their non-affected siblings up until the last 9 days before onset. During these 9 days they showed a decreased weight gain compared to their healthy litter-mates regardless of age. We conclude that decreased weight gain precedes the abrupt clinical onset of diabetes in BB rats and that it may be due to processes associated with the selective loss of β cells.</p>}},
author = {{Markholst, Helle and Eastman, Susan and Wilson, Deborah and Fisher, Lloyd and Lernmark, Åke}},
issn = {{0168-8227}},
keywords = {{Body weight; Growth velocity; Prediabetes; Type 1 diabetes}},
language = {{eng}},
month = {{01}},
number = {{1}},
pages = {{31--38}},
publisher = {{Elsevier}},
series = {{Diabetes Research and Clinical Practice}},
title = {{Decreased weight gain in BB rats before the clinical onset of insulin-dependent diabetes}},
url = {{http://dx.doi.org/10.1016/0168-8227(93)90094-L}},
doi = {{10.1016/0168-8227(93)90094-L}},
volume = {{21}},
year = {{1993}},
}