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Update on the pathophysiology of transfusion-related acute lung injury

Zeeuw van der Laan, Eveline A.N. ; van der Velden, Saskia ; Porcelijn, Leendert ; Semple, John W. LU ; van der Schoot, C. Ellen and Kapur, Rick LU (2020) In Current Opinion in Hematology 27(6). p.386-391
Abstract

PURPOSE OF REVIEW: The aim of this study was to discuss recent advances regarding the pathogenesis of transfusion-related acute lung injury (TRALI), which highlight the pathogenic role of macrophages. RECENT FINDINGS: TRALI remains a leading cause of transfusion-related fatalities, despite the success of the mitigation strategy, and therapeutic approaches are unavailable. Neutrophils (PMNs) are recognized pathogenic cells in TRALI. Macrophages have previously also been suggested to be pathogenic in mice via binding of C5a to their C5a-receptor, producing reactive oxygen species (ROS), which damages the pulmonary endothelium. Recent work has further highlighted the role of macrophages in the TRALI-pathogenesis. It has been shown that the... (More)

PURPOSE OF REVIEW: The aim of this study was to discuss recent advances regarding the pathogenesis of transfusion-related acute lung injury (TRALI), which highlight the pathogenic role of macrophages. RECENT FINDINGS: TRALI remains a leading cause of transfusion-related fatalities, despite the success of the mitigation strategy, and therapeutic approaches are unavailable. Neutrophils (PMNs) are recognized pathogenic cells in TRALI. Macrophages have previously also been suggested to be pathogenic in mice via binding of C5a to their C5a-receptor, producing reactive oxygen species (ROS), which damages the pulmonary endothelium. Recent work has further highlighted the role of macrophages in the TRALI-pathogenesis. It has been shown that the protein osteopontin (OPN) released by macrophages is critical for pulmonary PMN recruitment in mice suffering from TRALI and that targeting OPN prevents the occurrence of TRALI. Another recent study demonstrated the importance of M1-polarized alveolar macrophages in murine TRALI induction by showing that α1-antitrypsin (AAT) overexpression prevented TRALI in mice through decreasing the polarization of alveolar macrophages towards the M1 phenotype. SUMMARY: Apart from PMNs, macrophages also appear to be important in the pathogenesis of TRALI. Targeting the pathogenic functions of macrophages may be a promising therapeutic strategy to explore in TRALI.

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author
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Current Opinion in Hematology
volume
27
issue
6
pages
6 pages
publisher
Lippincott Williams & Wilkins
external identifiers
  • pmid:32868671
  • scopus:85092682031
ISSN
1531-7048
DOI
10.1097/MOH.0000000000000607
language
English
LU publication?
yes
id
2d19a02b-acb9-4e65-9614-8a785e8c964c
date added to LUP
2020-11-05 13:32:49
date last changed
2024-10-17 13:05:37
@article{2d19a02b-acb9-4e65-9614-8a785e8c964c,
  abstract     = {{<p>PURPOSE OF REVIEW: The aim of this study was to discuss recent advances regarding the pathogenesis of transfusion-related acute lung injury (TRALI), which highlight the pathogenic role of macrophages. RECENT FINDINGS: TRALI remains a leading cause of transfusion-related fatalities, despite the success of the mitigation strategy, and therapeutic approaches are unavailable. Neutrophils (PMNs) are recognized pathogenic cells in TRALI. Macrophages have previously also been suggested to be pathogenic in mice via binding of C5a to their C5a-receptor, producing reactive oxygen species (ROS), which damages the pulmonary endothelium. Recent work has further highlighted the role of macrophages in the TRALI-pathogenesis. It has been shown that the protein osteopontin (OPN) released by macrophages is critical for pulmonary PMN recruitment in mice suffering from TRALI and that targeting OPN prevents the occurrence of TRALI. Another recent study demonstrated the importance of M1-polarized alveolar macrophages in murine TRALI induction by showing that α1-antitrypsin (AAT) overexpression prevented TRALI in mice through decreasing the polarization of alveolar macrophages towards the M1 phenotype. SUMMARY: Apart from PMNs, macrophages also appear to be important in the pathogenesis of TRALI. Targeting the pathogenic functions of macrophages may be a promising therapeutic strategy to explore in TRALI.</p>}},
  author       = {{Zeeuw van der Laan, Eveline A.N. and van der Velden, Saskia and Porcelijn, Leendert and Semple, John W. and van der Schoot, C. Ellen and Kapur, Rick}},
  issn         = {{1531-7048}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{386--391}},
  publisher    = {{Lippincott Williams & Wilkins}},
  series       = {{Current Opinion in Hematology}},
  title        = {{Update on the pathophysiology of transfusion-related acute lung injury}},
  url          = {{http://dx.doi.org/10.1097/MOH.0000000000000607}},
  doi          = {{10.1097/MOH.0000000000000607}},
  volume       = {{27}},
  year         = {{2020}},
}