Coccidian infection causes oxidative damage in greenfinches
(2012) In PLoS ONE 7.- Abstract
- The main tenet of immunoecology is that individual variation in immune responsiveness is caused by the costs of immune responses to the hosts. Oxidative damage resulting from the excessive production of reactive oxygen species during immune response is hypothesized to form one of such costs. We tested this hypothesis in experimental coccidian infection model in greenfinches Carduelis chloris. Administration of isosporan coccidians to experimental birds did not affect indices of antioxidant protection (TAC and OXY), plasma triglyceride and carotenoid levels or body mass, indicating that pathological consequences of infection were generally mild. Infected birds had on average 8% higher levels of plasma malondialdehyde (MDA, a toxic... (More)
- The main tenet of immunoecology is that individual variation in immune responsiveness is caused by the costs of immune responses to the hosts. Oxidative damage resulting from the excessive production of reactive oxygen species during immune response is hypothesized to form one of such costs. We tested this hypothesis in experimental coccidian infection model in greenfinches Carduelis chloris. Administration of isosporan coccidians to experimental birds did not affect indices of antioxidant protection (TAC and OXY), plasma triglyceride and carotenoid levels or body mass, indicating that pathological consequences of infection were generally mild. Infected birds had on average 8% higher levels of plasma malondialdehyde (MDA, a toxic end-product of lipid peroxidation) than un-infected birds. The birds that had highest MDA levels subsequent to experimental infection experienced the highest decrease in infection intensity. This observation is consistent with the idea that oxidative stress is a causative agent in the control of coccidiosis and supports the concept of oxidative costs of immune responses and parasite resistance. The finding that oxidative damage accompanies even the mild infection with a common parasite highlights the relevance of oxidative stress biology for the immunoecological research. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3359208
- author
- Sepp, T. ; Karu, U. ; Blount, J. D. ; Sild, Elin LU ; Männiste, M. and Hõrak, P.
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- in
- PLoS ONE
- volume
- 7
- publisher
- Public Library of Science (PLoS)
- external identifiers
-
- scopus:84866179293
- pmid:22615772
- ISSN
- 1932-6203
- DOI
- 10.1371/journal.pone.0036495
- language
- English
- LU publication?
- no
- additional info
- 5
- id
- 2d2bb5e2-fdd5-48b9-98f8-7f747e1cca95 (old id 3359208)
- date added to LUP
- 2016-04-01 14:55:35
- date last changed
- 2022-04-22 05:52:49
@article{2d2bb5e2-fdd5-48b9-98f8-7f747e1cca95,
abstract = {{The main tenet of immunoecology is that individual variation in immune responsiveness is caused by the costs of immune responses to the hosts. Oxidative damage resulting from the excessive production of reactive oxygen species during immune response is hypothesized to form one of such costs. We tested this hypothesis in experimental coccidian infection model in greenfinches Carduelis chloris. Administration of isosporan coccidians to experimental birds did not affect indices of antioxidant protection (TAC and OXY), plasma triglyceride and carotenoid levels or body mass, indicating that pathological consequences of infection were generally mild. Infected birds had on average 8% higher levels of plasma malondialdehyde (MDA, a toxic end-product of lipid peroxidation) than un-infected birds. The birds that had highest MDA levels subsequent to experimental infection experienced the highest decrease in infection intensity. This observation is consistent with the idea that oxidative stress is a causative agent in the control of coccidiosis and supports the concept of oxidative costs of immune responses and parasite resistance. The finding that oxidative damage accompanies even the mild infection with a common parasite highlights the relevance of oxidative stress biology for the immunoecological research.}},
author = {{Sepp, T. and Karu, U. and Blount, J. D. and Sild, Elin and Männiste, M. and Hõrak, P.}},
issn = {{1932-6203}},
language = {{eng}},
publisher = {{Public Library of Science (PLoS)}},
series = {{PLoS ONE}},
title = {{Coccidian infection causes oxidative damage in greenfinches}},
url = {{http://dx.doi.org/10.1371/journal.pone.0036495}},
doi = {{10.1371/journal.pone.0036495}},
volume = {{7}},
year = {{2012}},
}