Redefining the role of syndecans in C. elegans biology
Gopal, Sandeep LU
; Couchman, John
and Pocock, Roger
(2016)
In Worm
5(1).
p.1-1142042
- Abstract
Cytosolic calcium is an important factor during fertilization, development and differentiation. Hence, the control of cytosolic calcium levels has been studied extensively for several decades. Numerous calcium channels have been identified and their mechanism of action elucidated. However, the mode of calcium channel regulation remains elusive. Here we discuss our recent findings regarding the role of syndecans in the regulation of cytosolic calcium levels. Syndecans are transmembrane proteoglycans present in both vertebrates and invertebrates that interact with extracellular ligands resulting in the activation of several downstream signaling pathways. We identified a previously unappreciated role of syndecans in cytosolic calcium... (More)
Cytosolic calcium is an important factor during fertilization, development and differentiation. Hence, the control of cytosolic calcium levels has been studied extensively for several decades. Numerous calcium channels have been identified and their mechanism of action elucidated. However, the mode of calcium channel regulation remains elusive. Here we discuss our recent findings regarding the role of syndecans in the regulation of cytosolic calcium levels. Syndecans are transmembrane proteoglycans present in both vertebrates and invertebrates that interact with extracellular ligands resulting in the activation of several downstream signaling pathways. We identified a previously unappreciated role of syndecans in cytosolic calcium regulation in mammals that is conserved in C. elegans. We concluded that calcium regulation is the basic, evolutionarily conserved role for syndecans, which enables them to be integral for multiple cellular functions.
(Less)
- author
- Gopal, Sandeep
LU
; Couchman, John
and Pocock, Roger
- publishing date
- 2016
- type
- Contribution to journal
- publication status
- published
- in
- Worm
- volume
- 5
- issue
- 1
- article number
- e1142042
- pages
- 1 - 1142042
- external identifiers
-
- pmid:27073736
- ISSN
- 2162-4046
- DOI
- 10.1080/21624054.2016.1142042
- language
- English
- LU publication?
- no
- id
- 2daac017-c398-4772-9db9-db15069c2ab9
- date added to LUP
- 2021-10-25 13:14:08
- date last changed
- 2021-10-26 02:30:54
@article{2daac017-c398-4772-9db9-db15069c2ab9,
abstract = {{<p>Cytosolic calcium is an important factor during fertilization, development and differentiation. Hence, the control of cytosolic calcium levels has been studied extensively for several decades. Numerous calcium channels have been identified and their mechanism of action elucidated. However, the mode of calcium channel regulation remains elusive. Here we discuss our recent findings regarding the role of syndecans in the regulation of cytosolic calcium levels. Syndecans are transmembrane proteoglycans present in both vertebrates and invertebrates that interact with extracellular ligands resulting in the activation of several downstream signaling pathways. We identified a previously unappreciated role of syndecans in cytosolic calcium regulation in mammals that is conserved in C. elegans. We concluded that calcium regulation is the basic, evolutionarily conserved role for syndecans, which enables them to be integral for multiple cellular functions. </p>}},
author = {{Gopal, Sandeep and Couchman, John and Pocock, Roger}},
issn = {{2162-4046}},
language = {{eng}},
number = {{1}},
pages = {{1--1142042}},
series = {{Worm}},
title = {{Redefining the role of syndecans in C. elegans biology}},
url = {{http://dx.doi.org/10.1080/21624054.2016.1142042}},
doi = {{10.1080/21624054.2016.1142042}},
volume = {{5}},
year = {{2016}},
}