Frequent hemodialysis versus standard hemodialysis for people with kidney failure : Systematic review and meta-analysis of randomized controlled trials
(2024) In PLoS ONE 19(9).- Abstract
Background Frequent hemodialysis provided more than three times per week may lower mortality and improve health-related quality of life. Yet, the evidence is inconclusive. We evaluated the benefits and harms of frequent hemodialysis in people with kidney failure compared with standard hemodialysis. Methods We performed a systematic review of randomized controlled trials including adults on hemodialysis with highly sensitive searching in MEDLINE, Embase, CENTRAL, and Google Scholar on 3 January 2024. Data were pooled using random-effects meta-analysis. Risk of bias was assessed using the Cochrane Risk of Bias 2 tool. We adjudicated evidence certainty using GRADE. Results From 11,142 unique citations, only seven studies involving 518... (More)
Background Frequent hemodialysis provided more than three times per week may lower mortality and improve health-related quality of life. Yet, the evidence is inconclusive. We evaluated the benefits and harms of frequent hemodialysis in people with kidney failure compared with standard hemodialysis. Methods We performed a systematic review of randomized controlled trials including adults on hemodialysis with highly sensitive searching in MEDLINE, Embase, CENTRAL, and Google Scholar on 3 January 2024. Data were pooled using random-effects meta-analysis. Risk of bias was assessed using the Cochrane Risk of Bias 2 tool. We adjudicated evidence certainty using GRADE. Results From 11,142 unique citations, only seven studies involving 518 participants proved eligible. The effects of frequent hemodialysis on physical and mental health were imprecise due to few data. Frequent hemodialysis probably had uncertain effect on death from all cause compared with standard hemodialysis (relative risk 0.79, 95% confidence interval 0.33–1.91, low certainty evidence). Data were not reported for death from cardiovascular causes, major cardiovascular events, fatigue or vascular access. Conclusion The evidentiary basis for frequent hemodialysis is incomplete due to clinical trials with few or no events reported for mortality and cardiovascular outcome measures and few participants in which patient-reported outcomes including health-related quality of life and symptoms were reported.
(Less)
- author
- organization
- publishing date
- 2024-09
- type
- Contribution to journal
- publication status
- published
- subject
- in
- PLoS ONE
- volume
- 19
- issue
- 9
- article number
- e0309773
- publisher
- Public Library of Science (PLoS)
- external identifiers
-
- scopus:85203332140
- pmid:39240930
- ISSN
- 1932-6203
- DOI
- 10.1371/journal.pone.0309773
- language
- English
- LU publication?
- yes
- id
- 2db634ce-8c4d-4b7c-a45f-e417a13117eb
- date added to LUP
- 2024-11-19 11:34:24
- date last changed
- 2024-12-17 14:38:21
@article{2db634ce-8c4d-4b7c-a45f-e417a13117eb,
abstract = {{<p>Background Frequent hemodialysis provided more than three times per week may lower mortality and improve health-related quality of life. Yet, the evidence is inconclusive. We evaluated the benefits and harms of frequent hemodialysis in people with kidney failure compared with standard hemodialysis. Methods We performed a systematic review of randomized controlled trials including adults on hemodialysis with highly sensitive searching in MEDLINE, Embase, CENTRAL, and Google Scholar on 3 January 2024. Data were pooled using random-effects meta-analysis. Risk of bias was assessed using the Cochrane Risk of Bias 2 tool. We adjudicated evidence certainty using GRADE. Results From 11,142 unique citations, only seven studies involving 518 participants proved eligible. The effects of frequent hemodialysis on physical and mental health were imprecise due to few data. Frequent hemodialysis probably had uncertain effect on death from all cause compared with standard hemodialysis (relative risk 0.79, 95% confidence interval 0.33–1.91, low certainty evidence). Data were not reported for death from cardiovascular causes, major cardiovascular events, fatigue or vascular access. Conclusion The evidentiary basis for frequent hemodialysis is incomplete due to clinical trials with few or no events reported for mortality and cardiovascular outcome measures and few participants in which patient-reported outcomes including health-related quality of life and symptoms were reported.</p>}},
author = {{Natale, Patrizia and Green, Suetonia C. and Rose, Matthias and Bots, Michiel L. and Blankestijn, Peter J. and Vernooij, Robin W.M. and Gerittsen, Karin and Woodward, Mark and Hockham, Carinna and Cromm, Krister and Barth, Claudia and Davenport, Andrew and Hegbrant, Jörgen and Sarafidis, Pantelis and Das, Partha and Wanner, Christoph and Nissenson, Allan R. and Sautenet, Benedicte and Török, Marietta and Strippoli, Giovanni}},
issn = {{1932-6203}},
language = {{eng}},
number = {{9}},
publisher = {{Public Library of Science (PLoS)}},
series = {{PLoS ONE}},
title = {{Frequent hemodialysis versus standard hemodialysis for people with kidney failure : Systematic review and meta-analysis of randomized controlled trials}},
url = {{http://dx.doi.org/10.1371/journal.pone.0309773}},
doi = {{10.1371/journal.pone.0309773}},
volume = {{19}},
year = {{2024}},
}