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Differences Between Parkinson's and Huntington's Diseases and Their Role for Prioritization of Stem Cell-Based Treatments

Hug, Kristina LU and Hermerén, Göran LU (2013) In Current Molecular Medicine 13(5). p.777-791
Abstract
The problems of allocation of scarce resources and priority setting in health care have so far not been much studied in the context of stem cell-based therapeutic applications. If and when competitive cost-effective stem cell-based therapies are available, the problem of priority setting - to whom should stem cell-based therapies be offered and on what grounds - is discussed in this article using the examples of Parkinson's Disease (PD) and Huntington's Disease (HD). The aim of this paper is to examine the presently known differences between PD and HD and analyze the role of these differences for setting priorities of stem cell-based therapeutic applications to treat these diseases. To achieve this aim, we (1) present the theoretical... (More)
The problems of allocation of scarce resources and priority setting in health care have so far not been much studied in the context of stem cell-based therapeutic applications. If and when competitive cost-effective stem cell-based therapies are available, the problem of priority setting - to whom should stem cell-based therapies be offered and on what grounds - is discussed in this article using the examples of Parkinson's Disease (PD) and Huntington's Disease (HD). The aim of this paper is to examine the presently known differences between PD and HD and analyze the role of these differences for setting priorities of stem cell-based therapeutic applications to treat these diseases. To achieve this aim, we (1) present the theoretical framework used in the analysis; (2) compare PD and HD in terms of health related and non-health related consequences of these diseases for patients, their relatives and third parties; (3) analyze the ethical relevance of observed differences for priority setting given different values and variables; (4) compare PD and HD in terms of social justice related consequences of stem cell-based therapies; and (5) analyze the ethical relevance of these differences for priority setting given different values and variables. We argue that the steps of analysis applied in this paper could be helpful when setting priorities among treatments of other diseases with similar differences as those between PD and HD. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Differences, ethical theories, Huntington's disease, Parkinson's, disease, priority setting, stem cell-based therapies, values
in
Current Molecular Medicine
volume
13
issue
5
pages
777 - 791
publisher
Bentham Science Publishers
external identifiers
  • wos:000319324700009
  • pmid:23642059
  • scopus:84881364225
ISSN
1566-5240
DOI
10.2174/1566524011313050009
language
English
LU publication?
yes
id
2df154f2-c120-4a52-bad6-e0a4d67dbe72 (old id 3931440)
date added to LUP
2013-08-01 07:39:07
date last changed
2019-03-08 02:15:18
@article{2df154f2-c120-4a52-bad6-e0a4d67dbe72,
  abstract     = {The problems of allocation of scarce resources and priority setting in health care have so far not been much studied in the context of stem cell-based therapeutic applications. If and when competitive cost-effective stem cell-based therapies are available, the problem of priority setting - to whom should stem cell-based therapies be offered and on what grounds - is discussed in this article using the examples of Parkinson's Disease (PD) and Huntington's Disease (HD). The aim of this paper is to examine the presently known differences between PD and HD and analyze the role of these differences for setting priorities of stem cell-based therapeutic applications to treat these diseases. To achieve this aim, we (1) present the theoretical framework used in the analysis; (2) compare PD and HD in terms of health related and non-health related consequences of these diseases for patients, their relatives and third parties; (3) analyze the ethical relevance of observed differences for priority setting given different values and variables; (4) compare PD and HD in terms of social justice related consequences of stem cell-based therapies; and (5) analyze the ethical relevance of these differences for priority setting given different values and variables. We argue that the steps of analysis applied in this paper could be helpful when setting priorities among treatments of other diseases with similar differences as those between PD and HD.},
  author       = {Hug, Kristina and Hermerén, Göran},
  issn         = {1566-5240},
  keyword      = {Differences,ethical theories,Huntington's disease,Parkinson's,disease,priority setting,stem cell-based therapies,values},
  language     = {eng},
  number       = {5},
  pages        = {777--791},
  publisher    = {Bentham Science Publishers},
  series       = {Current Molecular Medicine},
  title        = {Differences Between Parkinson's and Huntington's Diseases and Their Role for Prioritization of Stem Cell-Based Treatments},
  url          = {http://dx.doi.org/10.2174/1566524011313050009},
  volume       = {13},
  year         = {2013},
}