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Prevalence of Cancer in Patients with Venous Thromboembolism : A Retrospective Nationwide Case-Control Study in Sweden

Glise Sandblad, Katarina ; Hansson, Per-Olof ; Philipson, Jacob ; Mahmoud, Ahmad LU ; Karlsson, Per ; Rosengren, Annika and Sörbo, Jan (2023) In Clinical and Applied Thrombosis/Hemostasis 29.
Abstract

Cancer is a risk factor for venous thromboembolism (VTE). We aimed to define sex-specific risk of preceding cancer in patients with a first-time VTE by conducting a nationwide Swedish registry-based study including 298 172 patients with VTE and 1 185 079 matched controls. This included 44 685 patients with a diagnosis of cancer at/or within 1 year before a VTE diagnosis. Female patients with VTE had a higher multivariable adjusted odds ratios of preceding cancer than male patients with VTE (5.5 [99% confidence interval 5.4-5.7] vs 3.9 [3.8-4.0]). The highest risk of cancer in patients with VTE were found for pancreatic cancer (women: 19.6 [15.8-24.4]; men: 17.2 [13.7-21.6]) and brain cancer (women: 17.4 [12.9-23.4]; men: 17.5... (More)

Cancer is a risk factor for venous thromboembolism (VTE). We aimed to define sex-specific risk of preceding cancer in patients with a first-time VTE by conducting a nationwide Swedish registry-based study including 298 172 patients with VTE and 1 185 079 matched controls. This included 44 685 patients with a diagnosis of cancer at/or within 1 year before a VTE diagnosis. Female patients with VTE had a higher multivariable adjusted odds ratios of preceding cancer than male patients with VTE (5.5 [99% confidence interval 5.4-5.7] vs 3.9 [3.8-4.0]). The highest risk of cancer in patients with VTE were found for pancreatic cancer (women: 19.6 [15.8-24.4]; men: 17.2 [13.7-21.6]) and brain cancer (women: 17.4 [12.9-23.4]; men: 17.5 [13.8-22.2]). Weak associations were seen between VTE and bladder/urothelial cancer (women: 1.31 [1.12-1.53]; men: 1.34 [1.23-1.47]), prostate cancer (men: 2.17 [2.07-2.27]), malignant melanoma (women: 2.51 [2.07-3.05]; men: 2.67 [2.23-3.18]), and kidney cancer (women: 3.20 [2.49-4.11]; men: 3.33 [2.79-4.07]). In conclusion, associations with VTE were weak for bladder/urothelial cancer and kidney cancer, and strong for pancreatic, brain, and biliary cancers.

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author
; ; ; ; ; and
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Humans, Female, Male, Case-Control Studies, Retrospective Studies, Sweden/epidemiology, Venous Thromboembolism/epidemiology, Prevalence, Melanoma, Carcinoma, Renal Cell, Kidney Neoplasms, Frailty
in
Clinical and Applied Thrombosis/Hemostasis
volume
29
article number
10760296231158368
publisher
SAGE Publications
external identifiers
  • scopus:85148974731
  • pmid:36851858
ISSN
1938-2723
DOI
10.1177/10760296231158368
language
English
LU publication?
no
id
2df4d3a2-8952-4455-9f9a-9f248edf9704
date added to LUP
2025-03-05 14:53:15
date last changed
2025-07-10 15:02:27
@article{2df4d3a2-8952-4455-9f9a-9f248edf9704,
  abstract     = {{<p>Cancer is a risk factor for venous thromboembolism (VTE). We aimed to define sex-specific risk of preceding cancer in patients with a first-time VTE by conducting a nationwide Swedish registry-based study including 298 172 patients with VTE and 1 185 079 matched controls. This included 44 685 patients with a diagnosis of cancer at/or within 1 year before a VTE diagnosis. Female patients with VTE had a higher multivariable adjusted odds ratios of preceding cancer than male patients with VTE (5.5 [99% confidence interval 5.4-5.7] vs 3.9 [3.8-4.0]). The highest risk of cancer in patients with VTE were found for pancreatic cancer (women: 19.6 [15.8-24.4]; men: 17.2 [13.7-21.6]) and brain cancer (women: 17.4 [12.9-23.4]; men: 17.5 [13.8-22.2]). Weak associations were seen between VTE and bladder/urothelial cancer (women: 1.31 [1.12-1.53]; men: 1.34 [1.23-1.47]), prostate cancer (men: 2.17 [2.07-2.27]), malignant melanoma (women: 2.51 [2.07-3.05]; men: 2.67 [2.23-3.18]), and kidney cancer (women: 3.20 [2.49-4.11]; men: 3.33 [2.79-4.07]). In conclusion, associations with VTE were weak for bladder/urothelial cancer and kidney cancer, and strong for pancreatic, brain, and biliary cancers.</p>}},
  author       = {{Glise Sandblad, Katarina and Hansson, Per-Olof and Philipson, Jacob and Mahmoud, Ahmad and Karlsson, Per and Rosengren, Annika and Sörbo, Jan}},
  issn         = {{1938-2723}},
  keywords     = {{Humans; Female; Male; Case-Control Studies; Retrospective Studies; Sweden/epidemiology; Venous Thromboembolism/epidemiology; Prevalence; Melanoma; Carcinoma, Renal Cell; Kidney Neoplasms; Frailty}},
  language     = {{eng}},
  publisher    = {{SAGE Publications}},
  series       = {{Clinical and Applied Thrombosis/Hemostasis}},
  title        = {{Prevalence of Cancer in Patients with Venous Thromboembolism : A Retrospective Nationwide Case-Control Study in Sweden}},
  url          = {{http://dx.doi.org/10.1177/10760296231158368}},
  doi          = {{10.1177/10760296231158368}},
  volume       = {{29}},
  year         = {{2023}},
}