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Autoimmune diseases, asthma and risk of haematological malignancies: A nationwide case-control study in Sweden

Soderberg, Karin C.; Jonsson, Fredrik; Winqvist, Ola; Hagmar, Lars LU and Feychting, Maria (2006) In European Journal of Cancer 42(17). p.3028-3033
Abstract
To investigate potential associations between several autoimmune diseases and haematological malignancies, we studied 39,908 cases of leukaemia, Hodgkin's disease, non-Hodgkin's lymphoma and myeloma that occurred during 1987-1999 in Sweden, and 149,344 controls. Hospital discharge diagnoses of psoriasis, Sjogren's syndrome, autoimmune haemolytic anaemia, idiopathic thrombocytopenic purpura, pernicious anaemia, multiple sclerosis, rheumatic fever or asthma from 1969 to 1999 were retrieved from the Swedish Hospital Discharge Registry. Psoriasis was positively associated with leukaemia, excluding chronic lymphocytic leukaemia, (odds ratio [OR] = 1.6, 95% confidence interval [CI] 1.1-2.3) and non-Hodgkin's lymphoma (OR = 1.6, 95% CI 1.3-2.1).... (More)
To investigate potential associations between several autoimmune diseases and haematological malignancies, we studied 39,908 cases of leukaemia, Hodgkin's disease, non-Hodgkin's lymphoma and myeloma that occurred during 1987-1999 in Sweden, and 149,344 controls. Hospital discharge diagnoses of psoriasis, Sjogren's syndrome, autoimmune haemolytic anaemia, idiopathic thrombocytopenic purpura, pernicious anaemia, multiple sclerosis, rheumatic fever or asthma from 1969 to 1999 were retrieved from the Swedish Hospital Discharge Registry. Psoriasis was positively associated with leukaemia, excluding chronic lymphocytic leukaemia, (odds ratio [OR] = 1.6, 95% confidence interval [CI] 1.1-2.3) and non-Hodgkin's lymphoma (OR = 1.6, 95% CI 1.3-2.1). Sjogren's syndrome increased the risks of all haematological malignancies combined (OR = 4.0, 95% CI 2.3-7.0), and of non-Hodgkin's lymphoma (OR = 6.4, 95% CI 3.5-12). These findings, together with increased risks of several haematological malignancies in autoimmune haemolytic anaemia and idiopathic thrombocytopenic purpura but not in asthma, suggest chronic autoimmunity and immune stimulation as mechanisms contributing to the development of haematological malignancies. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
risk factors, autoimmune diseases, asthma, multiple myeloma, leukaemia, lymphoma
in
European Journal of Cancer
volume
42
issue
17
pages
3028 - 3033
publisher
IFAC & Elsevier Ltd.
external identifiers
  • wos:000242686100035
  • scopus:33750517284
ISSN
1879-0852
DOI
10.1016/j.ejca.2006.04.021
language
English
LU publication?
yes
id
2e1be7fc-7296-4e85-86b5-e9043a3e1ab9 (old id 683376)
date added to LUP
2008-01-03 16:56:14
date last changed
2019-10-08 01:40:11
@article{2e1be7fc-7296-4e85-86b5-e9043a3e1ab9,
  abstract     = {To investigate potential associations between several autoimmune diseases and haematological malignancies, we studied 39,908 cases of leukaemia, Hodgkin's disease, non-Hodgkin's lymphoma and myeloma that occurred during 1987-1999 in Sweden, and 149,344 controls. Hospital discharge diagnoses of psoriasis, Sjogren's syndrome, autoimmune haemolytic anaemia, idiopathic thrombocytopenic purpura, pernicious anaemia, multiple sclerosis, rheumatic fever or asthma from 1969 to 1999 were retrieved from the Swedish Hospital Discharge Registry. Psoriasis was positively associated with leukaemia, excluding chronic lymphocytic leukaemia, (odds ratio [OR] = 1.6, 95% confidence interval [CI] 1.1-2.3) and non-Hodgkin's lymphoma (OR = 1.6, 95% CI 1.3-2.1). Sjogren's syndrome increased the risks of all haematological malignancies combined (OR = 4.0, 95% CI 2.3-7.0), and of non-Hodgkin's lymphoma (OR = 6.4, 95% CI 3.5-12). These findings, together with increased risks of several haematological malignancies in autoimmune haemolytic anaemia and idiopathic thrombocytopenic purpura but not in asthma, suggest chronic autoimmunity and immune stimulation as mechanisms contributing to the development of haematological malignancies.},
  author       = {Soderberg, Karin C. and Jonsson, Fredrik and Winqvist, Ola and Hagmar, Lars and Feychting, Maria},
  issn         = {1879-0852},
  keyword      = {risk factors,autoimmune diseases,asthma,multiple myeloma,leukaemia,lymphoma},
  language     = {eng},
  number       = {17},
  pages        = {3028--3033},
  publisher    = {IFAC & Elsevier Ltd.},
  series       = {European Journal of Cancer},
  title        = {Autoimmune diseases, asthma and risk of haematological malignancies: A nationwide case-control study in Sweden},
  url          = {http://dx.doi.org/10.1016/j.ejca.2006.04.021},
  volume       = {42},
  year         = {2006},
}