Postmortem Studies of Fetal Grafts in Parkinson’s Disease : What Lessons Have We Learned?
(2021) In Frontiers in Cell and Developmental Biology 9.- Abstract
Neural transplantation is a potential therapeutic method for Parkinson’s disease (PD). Fetal dopaminergic (DA) neurons have been important transplantation cell sources in the history of replacement therapy for PD. Several decades of preclinical animal experiments and clinical trials using fetal DA neuron transplantation in PD therapy have shown not only promising results but also problems. In order to reveal possible factors influencing the clinical outcomes, we reviewed fetal DA neuron transplantation therapies from 1970s to present, with a special focus on postmortem studies. Firstly, we gave a general description of the clinical outcomes and neuroanatomy of grafted cases; secondly, we summarized the main available postmortem studies,... (More)
Neural transplantation is a potential therapeutic method for Parkinson’s disease (PD). Fetal dopaminergic (DA) neurons have been important transplantation cell sources in the history of replacement therapy for PD. Several decades of preclinical animal experiments and clinical trials using fetal DA neuron transplantation in PD therapy have shown not only promising results but also problems. In order to reveal possible factors influencing the clinical outcomes, we reviewed fetal DA neuron transplantation therapies from 1970s to present, with a special focus on postmortem studies. Firstly, we gave a general description of the clinical outcomes and neuroanatomy of grafted cases; secondly, we summarized the main available postmortem studies, including the cell survival, reinnervation, and pathology development. In the end, we further discussed the link between function and structure of the grafts, seeking for the possible factors contributing to a functional graft. With our review, we hope to provide references for future transplantation trials from a histological point of view.
(Less)
- author
- Li, Jia Yi LU and Li, Wen LU
- organization
- publishing date
- 2021-05-13
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- grafts, Lewy pathology, Parkinson’s disease, postmortem studies, transplantation
- in
- Frontiers in Cell and Developmental Biology
- volume
- 9
- article number
- 666675
- publisher
- Frontiers Media S. A.
- external identifiers
-
- pmid:34055800
- scopus:85107205676
- ISSN
- 2296-634X
- DOI
- 10.3389/fcell.2021.666675
- language
- English
- LU publication?
- yes
- id
- 2e4a927c-548a-44d7-b1d7-0e4ed6ea1852
- date added to LUP
- 2021-06-24 10:30:43
- date last changed
- 2024-06-30 16:20:52
@article{2e4a927c-548a-44d7-b1d7-0e4ed6ea1852,
abstract = {{<p>Neural transplantation is a potential therapeutic method for Parkinson’s disease (PD). Fetal dopaminergic (DA) neurons have been important transplantation cell sources in the history of replacement therapy for PD. Several decades of preclinical animal experiments and clinical trials using fetal DA neuron transplantation in PD therapy have shown not only promising results but also problems. In order to reveal possible factors influencing the clinical outcomes, we reviewed fetal DA neuron transplantation therapies from 1970s to present, with a special focus on postmortem studies. Firstly, we gave a general description of the clinical outcomes and neuroanatomy of grafted cases; secondly, we summarized the main available postmortem studies, including the cell survival, reinnervation, and pathology development. In the end, we further discussed the link between function and structure of the grafts, seeking for the possible factors contributing to a functional graft. With our review, we hope to provide references for future transplantation trials from a histological point of view.</p>}},
author = {{Li, Jia Yi and Li, Wen}},
issn = {{2296-634X}},
keywords = {{grafts; Lewy pathology; Parkinson’s disease; postmortem studies; transplantation}},
language = {{eng}},
month = {{05}},
publisher = {{Frontiers Media S. A.}},
series = {{Frontiers in Cell and Developmental Biology}},
title = {{Postmortem Studies of Fetal Grafts in Parkinson’s Disease : What Lessons Have We Learned?}},
url = {{http://dx.doi.org/10.3389/fcell.2021.666675}},
doi = {{10.3389/fcell.2021.666675}},
volume = {{9}},
year = {{2021}},
}