The usefulness of appetite and energy intake-based algorithms to assess treatment effect of a bacterial infection : An observational prospective study
(2017) In PLoS ONE 12(10).- Abstract
Background: The diagnosis of infectious diseases and the duration of antibiotic therapies are generally based on empirical rules. Studies implicate that the use biological markers can be used as a reliable method to shorten antibiotic therapies. The return of appetite is a clinical aspect of recovery from an infection that may be used to guide antibiotic therapies. Objective: To compare changes in appetite and daily energy intake with changes in CRP-levels in patients recovering from an infection. Design: Observational study using a consecutive sample of patients admitted to the unit for infectious diseases at a University Hospital in Sweden, February to April 2014. ... (More)
Background: The diagnosis of infectious diseases and the duration of antibiotic therapies are generally based on empirical rules. Studies implicate that the use biological markers can be used as a reliable method to shorten antibiotic therapies. The return of appetite is a clinical aspect of recovery from an infection that may be used to guide antibiotic therapies. Objective: To compare changes in appetite and daily energy intake with changes in CRP-levels in patients recovering from an infection. Design: Observational study using a consecutive sample of patients admitted to the unit for infectious diseases at a University Hospital in Sweden, February to April 2014. Energy intake, CRP-levels and appetite were recorded daily. Energy intake was calculated using estimated energy contents. Appetite was measured using a validated visual analogue scale. Changes in daily energy intakes, CRP-levels and appetite were analysed. Results: 49 patients (51% men) were included in the analysis from the overall population of 256 patients. During the length of the stay (median 3 days) CRP-levels fell in 92% of the patients (p<0.001), daily energy intake increased in 73% (median intake +6381 kJ/day, p<0.001) and appetite increased in 55% of the patients (p = 0.181). VAS-estimations of appetite augmented in 55%, decreased in 41% and were equal in 5% of the patients (p = 0.181). There was a non-significant difference in the within-subject variances in daily energy intake between female and male patients but not in other subsets. Conclusions: We found a significantly increase in the daily energy intake but not in self-estimated appetite in patients recovering from an infection. We suggest measuring the daily energy intake as a complement to other biological and clinical markers among inpatients to assess treatment effect.
(Less)
- author
- Peny, Viktor ; Månsson, Fredrik LU ; Resman, Fredrik LU ; Ahl, Jonas LU and Tham, Johan LU
- organization
- publishing date
- 2017-10-01
- type
- Contribution to journal
- publication status
- published
- subject
- in
- PLoS ONE
- volume
- 12
- issue
- 10
- article number
- e0186514
- publisher
- Public Library of Science (PLoS)
- external identifiers
-
- pmid:29073163
- wos:000413845400028
- scopus:85032449767
- ISSN
- 1932-6203
- DOI
- 10.1371/journal.pone.0186514
- language
- English
- LU publication?
- yes
- id
- 2e4e77c8-a2e5-4f4e-af2e-d54e4f549afd
- date added to LUP
- 2017-11-07 14:09:12
- date last changed
- 2024-03-01 01:39:15
@article{2e4e77c8-a2e5-4f4e-af2e-d54e4f549afd,
abstract = {{<p>Background: The diagnosis of infectious diseases and the duration of antibiotic therapies are generally based on empirical rules. Studies implicate that the use biological markers can be used as a reliable method to shorten antibiotic therapies. The return of appetite is a clinical aspect of recovery from an infection that may be used to guide antibiotic therapies. Objective: To compare changes in appetite and daily energy intake with changes in CRP-levels in patients recovering from an infection. Design: Observational study using a consecutive sample of patients admitted to the unit for infectious diseases at a University Hospital in Sweden, February to April 2014. Energy intake, CRP-levels and appetite were recorded daily. Energy intake was calculated using estimated energy contents. Appetite was measured using a validated visual analogue scale. Changes in daily energy intakes, CRP-levels and appetite were analysed. Results: 49 patients (51% men) were included in the analysis from the overall population of 256 patients. During the length of the stay (median 3 days) CRP-levels fell in 92% of the patients (p<0.001), daily energy intake increased in 73% (median intake +6381 kJ/day, p<0.001) and appetite increased in 55% of the patients (p = 0.181). VAS-estimations of appetite augmented in 55%, decreased in 41% and were equal in 5% of the patients (p = 0.181). There was a non-significant difference in the within-subject variances in daily energy intake between female and male patients but not in other subsets. Conclusions: We found a significantly increase in the daily energy intake but not in self-estimated appetite in patients recovering from an infection. We suggest measuring the daily energy intake as a complement to other biological and clinical markers among inpatients to assess treatment effect.</p>}},
author = {{Peny, Viktor and Månsson, Fredrik and Resman, Fredrik and Ahl, Jonas and Tham, Johan}},
issn = {{1932-6203}},
language = {{eng}},
month = {{10}},
number = {{10}},
publisher = {{Public Library of Science (PLoS)}},
series = {{PLoS ONE}},
title = {{The usefulness of appetite and energy intake-based algorithms to assess treatment effect of a bacterial infection : An observational prospective study}},
url = {{http://dx.doi.org/10.1371/journal.pone.0186514}},
doi = {{10.1371/journal.pone.0186514}},
volume = {{12}},
year = {{2017}},
}