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Allergic contact dermatitis caused by 1,6-hexanediol diacrylate in a hospital wristband

van Amerongen, Cynthia C.A. ; Dahlin, Jakob LU ; Isaksson, Marléne LU and Schuttelaar, Marie L.A. (2019) In Contact Dermatitis 81(6). p.446-449
Abstract

Background: 1,6-Hexanediol diacrylate (1,6-HDDA) is a multifunctional acrylate and a potent sensitizer. Objectives: To report a case of allergic contact dermatitis caused by 1,6-HDDA in a hospital wristband. Methods: A male patient presented with eczema on his wrist where he had worn a hospital wristband. Patch testing was performed with our extended European baseline series, additional series, and pieces of the hospital wristband. Thin-layer chromatography (TLC) was performed with extracts from the wristband and gas chromatography-mass spectrometry was used for chemical analysis. Results: Positive reactions were found to pieces of the wristband, including adhesive rim (+++), inside (+++), and outside (++); to multiple allergens in the... (More)

Background: 1,6-Hexanediol diacrylate (1,6-HDDA) is a multifunctional acrylate and a potent sensitizer. Objectives: To report a case of allergic contact dermatitis caused by 1,6-HDDA in a hospital wristband. Methods: A male patient presented with eczema on his wrist where he had worn a hospital wristband. Patch testing was performed with our extended European baseline series, additional series, and pieces of the hospital wristband. Thin-layer chromatography (TLC) was performed with extracts from the wristband and gas chromatography-mass spectrometry was used for chemical analysis. Results: Positive reactions were found to pieces of the wristband, including adhesive rim (+++), inside (+++), and outside (++); to multiple allergens in the (meth)acrylates series; and to extracts of the wristband in acetone and ethanol. Chemical analysis of the ethanol extract showed presence of lauryl acrylate and 1,6-HDDA. Patch testing with TLC strips and subsequent chemical analysis showed that the substance causing the strongest reaction was 1,6-HDDA, to which the patient had a confirmed positive patch test reaction. Conclusion: 1,6-HDDA was identified as the culprit allergen responsible for allergic contact dermatitis caused by the hospital wristband.

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organization
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type
Contribution to journal
publication status
published
subject
keywords
1,6-hexanediol diacrylate (1,6-HDDA), acrylate, allergic contact dermatitis, CAS no. 13048-33-4, case report, wristband
in
Contact Dermatitis
volume
81
issue
6
pages
446 - 449
publisher
Federation of European Neuroscience Societies and Blackwell Publishing Ltd
external identifiers
  • scopus:85071294534
  • pmid:31392731
ISSN
0105-1873
DOI
10.1111/cod.13378
language
English
LU publication?
yes
id
2e5337bd-2130-4834-b2d1-feece5241b44
date added to LUP
2019-09-03 08:38:31
date last changed
2020-01-14 12:21:17
@article{2e5337bd-2130-4834-b2d1-feece5241b44,
  abstract     = {<p>Background: 1,6-Hexanediol diacrylate (1,6-HDDA) is a multifunctional acrylate and a potent sensitizer. Objectives: To report a case of allergic contact dermatitis caused by 1,6-HDDA in a hospital wristband. Methods: A male patient presented with eczema on his wrist where he had worn a hospital wristband. Patch testing was performed with our extended European baseline series, additional series, and pieces of the hospital wristband. Thin-layer chromatography (TLC) was performed with extracts from the wristband and gas chromatography-mass spectrometry was used for chemical analysis. Results: Positive reactions were found to pieces of the wristband, including adhesive rim (+++), inside (+++), and outside (++); to multiple allergens in the (meth)acrylates series; and to extracts of the wristband in acetone and ethanol. Chemical analysis of the ethanol extract showed presence of lauryl acrylate and 1,6-HDDA. Patch testing with TLC strips and subsequent chemical analysis showed that the substance causing the strongest reaction was 1,6-HDDA, to which the patient had a confirmed positive patch test reaction. Conclusion: 1,6-HDDA was identified as the culprit allergen responsible for allergic contact dermatitis caused by the hospital wristband.</p>},
  author       = {van Amerongen, Cynthia C.A. and Dahlin, Jakob and Isaksson, Marléne and Schuttelaar, Marie L.A.},
  issn         = {0105-1873},
  language     = {eng},
  month        = {01},
  number       = {6},
  pages        = {446--449},
  publisher    = {Federation of European Neuroscience Societies and Blackwell Publishing Ltd},
  series       = {Contact Dermatitis},
  title        = {Allergic contact dermatitis caused by 1,6-hexanediol diacrylate in a hospital wristband},
  url          = {http://dx.doi.org/10.1111/cod.13378},
  doi          = {10.1111/cod.13378},
  volume       = {81},
  year         = {2019},
}