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Early-life exposure to perfluoroalkyl substances and serum antibody concentrations towards common childhood vaccines in 18-month-old children in the Odense Child Cohort

Sigvaldsen, Annika ; Højsager, Frederik Damsgaard ; Paarup, Helene Martina ; Beck, Iben Have LU ; Timmermann, Clara Amalie Gade ; Boye, Henriette ; Nielsen, Flemming ; Halldorsson, Thorhallur Ingi ; Nielsen, Christel LU orcid and Möller, Sören , et al. (2024) In Environmental Research 242.
Abstract

Exposure to per- and polyfluoroalkyl substances (PFAS) has been associated with reduced antibody response to childhood vaccinations. Previous studies have mostly focused on antibodies against diphtheria or tetanus, while fewer studies have assessed antibodies toward attenuated viruses, such as measles, mumps or rubella (MMR). Therefore, we set out to determine associations between prenatal and early postnatal PFAS exposure and vaccine-specific Immunoglobulin G (IgG) in the background-exposed Odense Child Cohort. Blood samples were drawn in pregnancy at gestation weeks 8–16 and from the offspring at age 18 months. In the maternal serum samples we quantified perfluorooctane sulfonic acid (PFOS), perfluorooctanoic acid (PFOA),... (More)

Exposure to per- and polyfluoroalkyl substances (PFAS) has been associated with reduced antibody response to childhood vaccinations. Previous studies have mostly focused on antibodies against diphtheria or tetanus, while fewer studies have assessed antibodies toward attenuated viruses, such as measles, mumps or rubella (MMR). Therefore, we set out to determine associations between prenatal and early postnatal PFAS exposure and vaccine-specific Immunoglobulin G (IgG) in the background-exposed Odense Child Cohort. Blood samples were drawn in pregnancy at gestation weeks 8–16 and from the offspring at age 18 months. In the maternal serum samples we quantified perfluorooctane sulfonic acid (PFOS), perfluorooctanoic acid (PFOA), perfluorohexane sulfonic acid (PFHxS), perfluorononanoic acid (PFNA) and perfluorodecanoic acid (PFDA). In the offspring serum samples we quantified the same five PFAS compounds and IgG towards diphtheria, tetanus and MMR. A total of 880 and 841 children were included in the analyses of diphtheria and tetanus or MMR, respectively. Multiple linear regression models were used for estimation of difference in virus-specific IgG per doubling of PFAS concentrations. Maternal PFAS concentrations were non-significantly inversely associated with most vaccine-specific antibody concentrations. Likewise, child PFAS concentrations were associated with non-significant reductions of antibodies towards tetanus and MMR. A significant reduction in the percent difference in mumps antibody concentration per doubling of child PFNA (−9.2% (95% confidence interval: −17.4;-0.2)), PFHxS (−8.3% (−15.0;-1.0) and PFOS (−7.9% (−14.8;-0.4) was found. These findings are of public health concern, as inadequate response towards childhood vaccines may represent a more general immune dysfunction.

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publishing date
type
Contribution to journal
publication status
published
subject
keywords
Antibodies, Children, Immune function, Perfluoroalkyl substances, Prospective cohort study, Vaccination
in
Environmental Research
volume
242
article number
117814
publisher
Elsevier
external identifiers
  • scopus:85179100817
  • pmid:38042520
ISSN
0013-9351
DOI
10.1016/j.envres.2023.117814
language
English
LU publication?
yes
additional info
Funding Information: This work was supported by Odense University Hospital , the Region of Southern Denmark, the Municipality of Odense, the Mental Health Service of the Region of Southern Denmark, OPEN Patient data Exploratory Network (OPEN), Novo Nordisk Foundation (grant nr. NNF15OC00017734 and NNF19OC0058266 ), the Danish Council for Independent Research ( 4004-00352B_FSS and 2034-00081B ), Health Insurance Denmark, The Foundation for research collaboration between Rigshospitalet and Odense University Hospital, the Health Foundation (Helsefonden), the National Institutes of Health ( ES027706 ) and the National Institute of Environmental Health Sciences ( P42ES027706 ). Publisher Copyright: © 2023
id
2e5d3486-190a-49dd-b3b7-0fb1af6ee0af
date added to LUP
2023-12-18 09:09:20
date last changed
2024-04-02 19:11:33
@article{2e5d3486-190a-49dd-b3b7-0fb1af6ee0af,
  abstract     = {{<p>Exposure to per- and polyfluoroalkyl substances (PFAS) has been associated with reduced antibody response to childhood vaccinations. Previous studies have mostly focused on antibodies against diphtheria or tetanus, while fewer studies have assessed antibodies toward attenuated viruses, such as measles, mumps or rubella (MMR). Therefore, we set out to determine associations between prenatal and early postnatal PFAS exposure and vaccine-specific Immunoglobulin G (IgG) in the background-exposed Odense Child Cohort. Blood samples were drawn in pregnancy at gestation weeks 8–16 and from the offspring at age 18 months. In the maternal serum samples we quantified perfluorooctane sulfonic acid (PFOS), perfluorooctanoic acid (PFOA), perfluorohexane sulfonic acid (PFHxS), perfluorononanoic acid (PFNA) and perfluorodecanoic acid (PFDA). In the offspring serum samples we quantified the same five PFAS compounds and IgG towards diphtheria, tetanus and MMR. A total of 880 and 841 children were included in the analyses of diphtheria and tetanus or MMR, respectively. Multiple linear regression models were used for estimation of difference in virus-specific IgG per doubling of PFAS concentrations. Maternal PFAS concentrations were non-significantly inversely associated with most vaccine-specific antibody concentrations. Likewise, child PFAS concentrations were associated with non-significant reductions of antibodies towards tetanus and MMR. A significant reduction in the percent difference in mumps antibody concentration per doubling of child PFNA (−9.2% (95% confidence interval: −17.4;-0.2)), PFHxS (−8.3% (−15.0;-1.0) and PFOS (−7.9% (−14.8;-0.4) was found. These findings are of public health concern, as inadequate response towards childhood vaccines may represent a more general immune dysfunction.</p>}},
  author       = {{Sigvaldsen, Annika and Højsager, Frederik Damsgaard and Paarup, Helene Martina and Beck, Iben Have and Timmermann, Clara Amalie Gade and Boye, Henriette and Nielsen, Flemming and Halldorsson, Thorhallur Ingi and Nielsen, Christel and Möller, Sören and Barington, Torben and Grandjean, Philippe and Jensen, Tina Kold}},
  issn         = {{0013-9351}},
  keywords     = {{Antibodies; Children; Immune function; Perfluoroalkyl substances; Prospective cohort study; Vaccination}},
  language     = {{eng}},
  month        = {{02}},
  publisher    = {{Elsevier}},
  series       = {{Environmental Research}},
  title        = {{Early-life exposure to perfluoroalkyl substances and serum antibody concentrations towards common childhood vaccines in 18-month-old children in the Odense Child Cohort}},
  url          = {{http://dx.doi.org/10.1016/j.envres.2023.117814}},
  doi          = {{10.1016/j.envres.2023.117814}},
  volume       = {{242}},
  year         = {{2024}},
}