Endothelial expression of MHC class II molecules in autoimmune disease
(2004) In Current Pharmaceutical Design 10(2). p.129-143- Abstract
- Major histocompatibility complex (MHC) class II molecules are up-regulated on endothelial cells in human allografts, and are thought to be involved in graft rejection. The MFIC class 11 subtypes HLA-DR, DQ and DP regulate T cell dependent immune responses, and aberrant expression could be important in autoimmunity. Increased endothelial MHC class II expression has been demonstrated in several autoimmune diseases, including myocarditis with dilated cardiomyopathy, rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Recent data suggest that there is an association between endothelial expression of MHC class II molecules and diffuse endothelial dysfunction, which may be part of the explanation of the increased risk of... (More)
- Major histocompatibility complex (MHC) class II molecules are up-regulated on endothelial cells in human allografts, and are thought to be involved in graft rejection. The MFIC class 11 subtypes HLA-DR, DQ and DP regulate T cell dependent immune responses, and aberrant expression could be important in autoimmunity. Increased endothelial MHC class II expression has been demonstrated in several autoimmune diseases, including myocarditis with dilated cardiomyopathy, rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Recent data suggest that there is an association between endothelial expression of MHC class II molecules and diffuse endothelial dysfunction, which may be part of the explanation of the increased risk of cardiovascular disease in patients with RA, SLE and other chronic inflammatory conditions. MHC class II transcription is in part genetically determined. Cytokine induced up-regulation of MHC class II molecules can be inhibited in vitro by antioxidants and different drugs, such as cyclosporin and statins. Research on the development of new treatments for systemic autoimmune diseases and cardiovascular disease should include evaluation of effects on endothelial activation, including MHC class II expression. This review also discusses the genetic basis of MHC class II expression and its implications for understanding MHC genotype associations with autoimmune diseases. Recent studies of interactions between endothelial cells and T cells are reviewed. Such interactions could be of major importance in the pathogenesis of autoimmune and vascular diseases. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/899561
- author
- Turesson, Carl LU
- organization
- publishing date
- 2004
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- major histocompatibility complex class II, endothelial cells, endothelial activation, HLA-DR, T cells, HLA-DQ, cardiovascular disease, rheumatoid arthritis
- in
- Current Pharmaceutical Design
- volume
- 10
- issue
- 2
- pages
- 129 - 143
- publisher
- Bentham Science Publishers
- external identifiers
-
- pmid:14754393
- wos:000187996700004
- scopus:0347286787
- ISSN
- 1381-6128
- DOI
- 10.2174/1381612043453414
- language
- English
- LU publication?
- yes
- id
- 2e8c6ffe-c367-4080-8bed-de5e711b6190 (old id 899561)
- date added to LUP
- 2016-04-01 11:45:32
- date last changed
- 2022-04-05 04:33:45
@article{2e8c6ffe-c367-4080-8bed-de5e711b6190,
abstract = {{Major histocompatibility complex (MHC) class II molecules are up-regulated on endothelial cells in human allografts, and are thought to be involved in graft rejection. The MFIC class 11 subtypes HLA-DR, DQ and DP regulate T cell dependent immune responses, and aberrant expression could be important in autoimmunity. Increased endothelial MHC class II expression has been demonstrated in several autoimmune diseases, including myocarditis with dilated cardiomyopathy, rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Recent data suggest that there is an association between endothelial expression of MHC class II molecules and diffuse endothelial dysfunction, which may be part of the explanation of the increased risk of cardiovascular disease in patients with RA, SLE and other chronic inflammatory conditions. MHC class II transcription is in part genetically determined. Cytokine induced up-regulation of MHC class II molecules can be inhibited in vitro by antioxidants and different drugs, such as cyclosporin and statins. Research on the development of new treatments for systemic autoimmune diseases and cardiovascular disease should include evaluation of effects on endothelial activation, including MHC class II expression. This review also discusses the genetic basis of MHC class II expression and its implications for understanding MHC genotype associations with autoimmune diseases. Recent studies of interactions between endothelial cells and T cells are reviewed. Such interactions could be of major importance in the pathogenesis of autoimmune and vascular diseases.}},
author = {{Turesson, Carl}},
issn = {{1381-6128}},
keywords = {{major histocompatibility complex class II; endothelial cells; endothelial activation; HLA-DR; T cells; HLA-DQ; cardiovascular disease; rheumatoid arthritis}},
language = {{eng}},
number = {{2}},
pages = {{129--143}},
publisher = {{Bentham Science Publishers}},
series = {{Current Pharmaceutical Design}},
title = {{Endothelial expression of MHC class II molecules in autoimmune disease}},
url = {{http://dx.doi.org/10.2174/1381612043453414}},
doi = {{10.2174/1381612043453414}},
volume = {{10}},
year = {{2004}},
}