Insulin Sensitivity and Carotid Intima-Media Thickness Relationship Between Insulin Sensitivity and Cardiovascular Risk Study
(2013) In Arteriosclerosis, Thrombosis and Vascular Biology 33(6). p.1409-1417- Abstract
- Objective-Despite a wealth of experimental data in animal models, the independent association of insulin resistance with early carotid atherosclerosis in man has not been demonstrated. Approach and Results-We studied a European cohort of 525 men and 655 women (mean age, 44 +/- 8 years) free of conditions known to affect carotid wall (diabetes mellitus, hypertension, and dyslipidemia). All subjects received an oral glucose tolerance test, a euglycemic hyperinsulinemic clamp (M/I as a measure of insulin sensitivity), and B-mode carotid ultrasound. In 833 participants (380 men), the carotid ultrasound was repeated after 3 years. In men, baseline intimamedia thickness in the common carotid artery (CCA-IMT) was significantly higher (P< 0.05)... (More)
- Objective-Despite a wealth of experimental data in animal models, the independent association of insulin resistance with early carotid atherosclerosis in man has not been demonstrated. Approach and Results-We studied a European cohort of 525 men and 655 women (mean age, 44 +/- 8 years) free of conditions known to affect carotid wall (diabetes mellitus, hypertension, and dyslipidemia). All subjects received an oral glucose tolerance test, a euglycemic hyperinsulinemic clamp (M/I as a measure of insulin sensitivity), and B-mode carotid ultrasound. In 833 participants (380 men), the carotid ultrasound was repeated after 3 years. In men, baseline intimamedia thickness in the common carotid artery (CCA-IMT) was significantly higher (P< 0.05) in the lowest M/I tertile, whereas in women CCA-IMT was higher (P< 0.0005) in the highest fasting plasma glucose tertile (after adjustment for established risk factors). In multiple regression models, with CCA-IMT as the dependent variable and with risk factors and univariate metabolic correlates as independent variables, circulating free fatty acids and the leptin: adiponectin ratio replaced M/ I as independent metabolic determinants of CCA-IMT in men. The strongest metabolic determinant of CCA-IMT in women was fasting plasma glucose. Three-year CCA-IMT changes were not associated with any cardiometabolic risk factor. Conclusions-In young-to-middle aged apparently healthy people, the association of CCA-IMT with insulin sensitivity and its metabolic correlates differs between men and women. Lower insulin sensitivity is associated with higher IMT only in men; this association seems to be mediated by circulating free fatty acids and adipocytokines. In women, CCA-IMT is independently associated with fasting plasma glucose. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3930665
- author
- Kozakova, Michaela ; Natali, Andrea ; Dekker, Jacqueline ; Beck-Nielsen, Henning ; Laakso, Markku ; Nilsson, Peter LU ; Balkau, Beverley and Ferrannini, Ele
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- adipokine., atherosclerosis, carotid intima, media thickness, fatty, acids, glucose
- in
- Arteriosclerosis, Thrombosis and Vascular Biology
- volume
- 33
- issue
- 6
- pages
- 1409 - 1417
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- wos:000319119500043
- scopus:84879109173
- pmid:23599442
- ISSN
- 1524-4636
- DOI
- 10.1161/ATVBAHA.112.300948
- language
- English
- LU publication?
- yes
- id
- 2eb1c73a-53b8-4ae7-9ba3-413ce964582a (old id 3930665)
- date added to LUP
- 2016-04-01 10:32:39
- date last changed
- 2022-04-12 07:18:17
@article{2eb1c73a-53b8-4ae7-9ba3-413ce964582a, abstract = {{Objective-Despite a wealth of experimental data in animal models, the independent association of insulin resistance with early carotid atherosclerosis in man has not been demonstrated. Approach and Results-We studied a European cohort of 525 men and 655 women (mean age, 44 +/- 8 years) free of conditions known to affect carotid wall (diabetes mellitus, hypertension, and dyslipidemia). All subjects received an oral glucose tolerance test, a euglycemic hyperinsulinemic clamp (M/I as a measure of insulin sensitivity), and B-mode carotid ultrasound. In 833 participants (380 men), the carotid ultrasound was repeated after 3 years. In men, baseline intimamedia thickness in the common carotid artery (CCA-IMT) was significantly higher (P< 0.05) in the lowest M/I tertile, whereas in women CCA-IMT was higher (P< 0.0005) in the highest fasting plasma glucose tertile (after adjustment for established risk factors). In multiple regression models, with CCA-IMT as the dependent variable and with risk factors and univariate metabolic correlates as independent variables, circulating free fatty acids and the leptin: adiponectin ratio replaced M/ I as independent metabolic determinants of CCA-IMT in men. The strongest metabolic determinant of CCA-IMT in women was fasting plasma glucose. Three-year CCA-IMT changes were not associated with any cardiometabolic risk factor. Conclusions-In young-to-middle aged apparently healthy people, the association of CCA-IMT with insulin sensitivity and its metabolic correlates differs between men and women. Lower insulin sensitivity is associated with higher IMT only in men; this association seems to be mediated by circulating free fatty acids and adipocytokines. In women, CCA-IMT is independently associated with fasting plasma glucose.}}, author = {{Kozakova, Michaela and Natali, Andrea and Dekker, Jacqueline and Beck-Nielsen, Henning and Laakso, Markku and Nilsson, Peter and Balkau, Beverley and Ferrannini, Ele}}, issn = {{1524-4636}}, keywords = {{adipokine.; atherosclerosis; carotid intima; media thickness; fatty; acids; glucose}}, language = {{eng}}, number = {{6}}, pages = {{1409--1417}}, publisher = {{Lippincott Williams & Wilkins}}, series = {{Arteriosclerosis, Thrombosis and Vascular Biology}}, title = {{Insulin Sensitivity and Carotid Intima-Media Thickness Relationship Between Insulin Sensitivity and Cardiovascular Risk Study}}, url = {{http://dx.doi.org/10.1161/ATVBAHA.112.300948}}, doi = {{10.1161/ATVBAHA.112.300948}}, volume = {{33}}, year = {{2013}}, }