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Insulin Sensitivity and Carotid Intima-Media Thickness Relationship Between Insulin Sensitivity and Cardiovascular Risk Study

Kozakova, Michaela ; Natali, Andrea ; Dekker, Jacqueline ; Beck-Nielsen, Henning ; Laakso, Markku ; Nilsson, Peter LU ; Balkau, Beverley and Ferrannini, Ele (2013) In Arteriosclerosis, Thrombosis and Vascular Biology 33(6). p.1409-1417
Abstract
Objective-Despite a wealth of experimental data in animal models, the independent association of insulin resistance with early carotid atherosclerosis in man has not been demonstrated. Approach and Results-We studied a European cohort of 525 men and 655 women (mean age, 44 +/- 8 years) free of conditions known to affect carotid wall (diabetes mellitus, hypertension, and dyslipidemia). All subjects received an oral glucose tolerance test, a euglycemic hyperinsulinemic clamp (M/I as a measure of insulin sensitivity), and B-mode carotid ultrasound. In 833 participants (380 men), the carotid ultrasound was repeated after 3 years. In men, baseline intimamedia thickness in the common carotid artery (CCA-IMT) was significantly higher (P< 0.05)... (More)
Objective-Despite a wealth of experimental data in animal models, the independent association of insulin resistance with early carotid atherosclerosis in man has not been demonstrated. Approach and Results-We studied a European cohort of 525 men and 655 women (mean age, 44 +/- 8 years) free of conditions known to affect carotid wall (diabetes mellitus, hypertension, and dyslipidemia). All subjects received an oral glucose tolerance test, a euglycemic hyperinsulinemic clamp (M/I as a measure of insulin sensitivity), and B-mode carotid ultrasound. In 833 participants (380 men), the carotid ultrasound was repeated after 3 years. In men, baseline intimamedia thickness in the common carotid artery (CCA-IMT) was significantly higher (P< 0.05) in the lowest M/I tertile, whereas in women CCA-IMT was higher (P< 0.0005) in the highest fasting plasma glucose tertile (after adjustment for established risk factors). In multiple regression models, with CCA-IMT as the dependent variable and with risk factors and univariate metabolic correlates as independent variables, circulating free fatty acids and the leptin: adiponectin ratio replaced M/ I as independent metabolic determinants of CCA-IMT in men. The strongest metabolic determinant of CCA-IMT in women was fasting plasma glucose. Three-year CCA-IMT changes were not associated with any cardiometabolic risk factor. Conclusions-In young-to-middle aged apparently healthy people, the association of CCA-IMT with insulin sensitivity and its metabolic correlates differs between men and women. Lower insulin sensitivity is associated with higher IMT only in men; this association seems to be mediated by circulating free fatty acids and adipocytokines. In women, CCA-IMT is independently associated with fasting plasma glucose. (Less)
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author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
adipokine., atherosclerosis, carotid intima, media thickness, fatty, acids, glucose
in
Arteriosclerosis, Thrombosis and Vascular Biology
volume
33
issue
6
pages
1409 - 1417
publisher
Lippincott Williams & Wilkins
external identifiers
  • wos:000319119500043
  • scopus:84879109173
  • pmid:23599442
ISSN
1524-4636
DOI
10.1161/ATVBAHA.112.300948
language
English
LU publication?
yes
id
2eb1c73a-53b8-4ae7-9ba3-413ce964582a (old id 3930665)
date added to LUP
2016-04-01 10:32:39
date last changed
2022-04-12 07:18:17
@article{2eb1c73a-53b8-4ae7-9ba3-413ce964582a,
  abstract     = {{Objective-Despite a wealth of experimental data in animal models, the independent association of insulin resistance with early carotid atherosclerosis in man has not been demonstrated. Approach and Results-We studied a European cohort of 525 men and 655 women (mean age, 44 +/- 8 years) free of conditions known to affect carotid wall (diabetes mellitus, hypertension, and dyslipidemia). All subjects received an oral glucose tolerance test, a euglycemic hyperinsulinemic clamp (M/I as a measure of insulin sensitivity), and B-mode carotid ultrasound. In 833 participants (380 men), the carotid ultrasound was repeated after 3 years. In men, baseline intimamedia thickness in the common carotid artery (CCA-IMT) was significantly higher (P&lt; 0.05) in the lowest M/I tertile, whereas in women CCA-IMT was higher (P&lt; 0.0005) in the highest fasting plasma glucose tertile (after adjustment for established risk factors). In multiple regression models, with CCA-IMT as the dependent variable and with risk factors and univariate metabolic correlates as independent variables, circulating free fatty acids and the leptin: adiponectin ratio replaced M/ I as independent metabolic determinants of CCA-IMT in men. The strongest metabolic determinant of CCA-IMT in women was fasting plasma glucose. Three-year CCA-IMT changes were not associated with any cardiometabolic risk factor. Conclusions-In young-to-middle aged apparently healthy people, the association of CCA-IMT with insulin sensitivity and its metabolic correlates differs between men and women. Lower insulin sensitivity is associated with higher IMT only in men; this association seems to be mediated by circulating free fatty acids and adipocytokines. In women, CCA-IMT is independently associated with fasting plasma glucose.}},
  author       = {{Kozakova, Michaela and Natali, Andrea and Dekker, Jacqueline and Beck-Nielsen, Henning and Laakso, Markku and Nilsson, Peter and Balkau, Beverley and Ferrannini, Ele}},
  issn         = {{1524-4636}},
  keywords     = {{adipokine.; atherosclerosis; carotid intima; media thickness; fatty; acids; glucose}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{1409--1417}},
  publisher    = {{Lippincott Williams & Wilkins}},
  series       = {{Arteriosclerosis, Thrombosis and Vascular Biology}},
  title        = {{Insulin Sensitivity and Carotid Intima-Media Thickness Relationship Between Insulin Sensitivity and Cardiovascular Risk Study}},
  url          = {{http://dx.doi.org/10.1161/ATVBAHA.112.300948}},
  doi          = {{10.1161/ATVBAHA.112.300948}},
  volume       = {{33}},
  year         = {{2013}},
}