Characterization of a novel calcium phosphate/sulphate bone cement
(2002) In Journal of Biomedical Materials Research 61(4). p.600-607- Abstract
- Apatitic cements have shown excellent biocompatibility and adequate mechanical properties but have slow resorption in the human body. To assure that new bone tissue grows into the bone defect, a certain porosity is necessary although hard to achieve in injectable cements with suitable mechanical properties. An attempt was made by mixing alpha-tricalcium phosphate (alpha-TCP), calcium sulphate hemihydrate (CSH) and an aqueous solution containing 2.5 wt% of Na2HPO4. The aim was to obtain a material containing two phases: a) one apatitic phase (calcium-deficient hydroxyapatite; CDHA) and b) one resorbable phase (calcium sulphate dihydrate; CSD). alpha-TCP and CSH mixtures were produced at relative intervals of 20 wt%. The liquid-to-powder... (More)
- Apatitic cements have shown excellent biocompatibility and adequate mechanical properties but have slow resorption in the human body. To assure that new bone tissue grows into the bone defect, a certain porosity is necessary although hard to achieve in injectable cements with suitable mechanical properties. An attempt was made by mixing alpha-tricalcium phosphate (alpha-TCP), calcium sulphate hemihydrate (CSH) and an aqueous solution containing 2.5 wt% of Na2HPO4. The aim was to obtain a material containing two phases: a) one apatitic phase (calcium-deficient hydroxyapatite; CDHA) and b) one resorbable phase (calcium sulphate dihydrate; CSD). alpha-TCP and CSH mixtures were produced at relative intervals of 20 wt%. The liquid-to-powder (L/P) ratio to obtain a paste was 0.32 mLg(-1). The highest compressive strength (34 MPa) was obtained for the pure alpha-TCP sample. The strength was, in a first approximation, directly correlated to the weight proportions of the powders. X-ray diffraction analysis showed that the relative intensity for CDHA increased linearly, and the one for CSD decreased exponentially, when the amount of alpha-TCP increased. Thus, CSH ceased to transform to CSD when the amount of alpha-TCP increased. Observations in environmental scanning electron microscopy confirmed the X-ray diffraction results. CSH-crystals (100 mum) were embedded in the HA-matrix permitting gradual porosity in the material when resorbed. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/334512
- author
- Nilsson, M ; Fernandez, E ; Sarda, S ; Lidgren, Lars LU and Planell, JA
- organization
- publishing date
- 2002
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- porosity, calcium sulphate, bone cement, alpha-tricalcium phosphate., biodegradable material
- in
- Journal of Biomedical Materials Research
- volume
- 61
- issue
- 4
- pages
- 600 - 607
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- wos:000176551800011
- pmid:12115450
- scopus:0037104981
- ISSN
- 0021-9304
- DOI
- 10.1002/jbm.10268
- language
- English
- LU publication?
- yes
- id
- 2eb5ce5f-5279-4004-a391-ceb049f3b004 (old id 334512)
- date added to LUP
- 2016-04-01 11:37:57
- date last changed
- 2022-04-28 17:38:47
@article{2eb5ce5f-5279-4004-a391-ceb049f3b004,
abstract = {{Apatitic cements have shown excellent biocompatibility and adequate mechanical properties but have slow resorption in the human body. To assure that new bone tissue grows into the bone defect, a certain porosity is necessary although hard to achieve in injectable cements with suitable mechanical properties. An attempt was made by mixing alpha-tricalcium phosphate (alpha-TCP), calcium sulphate hemihydrate (CSH) and an aqueous solution containing 2.5 wt% of Na2HPO4. The aim was to obtain a material containing two phases: a) one apatitic phase (calcium-deficient hydroxyapatite; CDHA) and b) one resorbable phase (calcium sulphate dihydrate; CSD). alpha-TCP and CSH mixtures were produced at relative intervals of 20 wt%. The liquid-to-powder (L/P) ratio to obtain a paste was 0.32 mLg(-1). The highest compressive strength (34 MPa) was obtained for the pure alpha-TCP sample. The strength was, in a first approximation, directly correlated to the weight proportions of the powders. X-ray diffraction analysis showed that the relative intensity for CDHA increased linearly, and the one for CSD decreased exponentially, when the amount of alpha-TCP increased. Thus, CSH ceased to transform to CSD when the amount of alpha-TCP increased. Observations in environmental scanning electron microscopy confirmed the X-ray diffraction results. CSH-crystals (100 mum) were embedded in the HA-matrix permitting gradual porosity in the material when resorbed.}},
author = {{Nilsson, M and Fernandez, E and Sarda, S and Lidgren, Lars and Planell, JA}},
issn = {{0021-9304}},
keywords = {{porosity; calcium sulphate; bone cement; alpha-tricalcium phosphate.; biodegradable material}},
language = {{eng}},
number = {{4}},
pages = {{600--607}},
publisher = {{John Wiley & Sons Inc.}},
series = {{Journal of Biomedical Materials Research}},
title = {{Characterization of a novel calcium phosphate/sulphate bone cement}},
url = {{http://dx.doi.org/10.1002/jbm.10268}},
doi = {{10.1002/jbm.10268}},
volume = {{61}},
year = {{2002}},
}