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High levels of cystatin C predict the metabolic syndrome: the prospective Malmö Diet and Cancer Study.

Magnusson, Martin LU orcid ; Hedblad, Bo LU ; Engström, Gunnar LU ; Persson, Magnus LU ; Nilsson, Peter LU and Melander, Olle LU orcid (2013) In Journal of Internal Medicine 274(2). p.192-199
Abstract
OBJECTIVE: Cystatin C is a novel marker of cardiovascular disease (CVD), however the underlying mechanisms remain unclear. Here, we prospectively investigated whether plasma levels of cystatin C predict new-onset metabolic syndrome (MetS) as well as long-term progression and incidence of the different components of the MetS. METHODS: Cystatin C was measured in 1502 individuals included in the Malmö Diet and Cancer cardiovascular cohort (mean age 56 years, 59% women) who were free from the MetS at baseline and subsequently underwent a follow-up examination after a median of 16 years. MetS was defined according to the NCEP-ATP-III guidelines. Logistic regression was used to adjust for covariates. MAIN OUTCOME MEASURES: MetS and long-term... (More)
OBJECTIVE: Cystatin C is a novel marker of cardiovascular disease (CVD), however the underlying mechanisms remain unclear. Here, we prospectively investigated whether plasma levels of cystatin C predict new-onset metabolic syndrome (MetS) as well as long-term progression and incidence of the different components of the MetS. METHODS: Cystatin C was measured in 1502 individuals included in the Malmö Diet and Cancer cardiovascular cohort (mean age 56 years, 59% women) who were free from the MetS at baseline and subsequently underwent a follow-up examination after a median of 16 years. MetS was defined according to the NCEP-ATP-III guidelines. Logistic regression was used to adjust for covariates. MAIN OUTCOME MEASURES: MetS and long-term progression as well as incidence of the different components of the MetS. RESULTS: During follow-up, 428 subjects developed new-onset MetS. In age- and sex-adjusted analysis, compared to the lowest quartile of cystatin C, the odds ratios (95% confidence interval) for incident MetS in subjects with cystatin C levels in quartiles 2, 3 and 4 were 1.00 (0.71-1.40), 1.48 (1.06-2.07) and 1.91 (1.37-2.68), respectively, (P(trend) <0.001); this linear association remained significant even after full multivariate adjustment (P(trend) =0.041). Interestingly, in this fully adjusted model, long-term progression of abdominal obesity was the only component of the MetS significantly associated with increasing quartiles of baseline cystatin C levels (P(trend) =0.008). CONCLUSION: These findings suggest that cystatin C may adversely affect metabolic factors, particularly abdominal obesity, thus contributing to development of the MetS. Our results may help to explain the link between cystatin C and development of CVD. © 2013 The Association for the Publication of the Journal of Internal Medicine. (Less)
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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Internal Medicine
volume
274
issue
2
pages
192 - 199
publisher
Wiley-Blackwell
external identifiers
  • wos:000321665200011
  • pmid:23414447
  • scopus:84880326575
  • pmid:23414447
ISSN
1365-2796
DOI
10.1111/joim.12051
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Cardio-vascular Epidemiology (013241610), Emergency medicine/Medicine/Surgery (013240200), Hypertension and Cardiovascular Disease (013242540), Internal Medicine Research Unit (013242520), Division of Health Economics and Forensic Medicine (Closed 2012) (013040050)
id
2eb965f8-8c4c-4452-b18d-d550b2424cfa (old id 3559702)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23414447?dopt=Abstract
date added to LUP
2016-04-01 10:46:32
date last changed
2024-01-07 00:49:31
@article{2eb965f8-8c4c-4452-b18d-d550b2424cfa,
  abstract     = {{OBJECTIVE: Cystatin C is a novel marker of cardiovascular disease (CVD), however the underlying mechanisms remain unclear. Here, we prospectively investigated whether plasma levels of cystatin C predict new-onset metabolic syndrome (MetS) as well as long-term progression and incidence of the different components of the MetS. METHODS: Cystatin C was measured in 1502 individuals included in the Malmö Diet and Cancer cardiovascular cohort (mean age 56 years, 59% women) who were free from the MetS at baseline and subsequently underwent a follow-up examination after a median of 16 years. MetS was defined according to the NCEP-ATP-III guidelines. Logistic regression was used to adjust for covariates. MAIN OUTCOME MEASURES: MetS and long-term progression as well as incidence of the different components of the MetS. RESULTS: During follow-up, 428 subjects developed new-onset MetS. In age- and sex-adjusted analysis, compared to the lowest quartile of cystatin C, the odds ratios (95% confidence interval) for incident MetS in subjects with cystatin C levels in quartiles 2, 3 and 4 were 1.00 (0.71-1.40), 1.48 (1.06-2.07) and 1.91 (1.37-2.68), respectively, (P(trend) &lt;0.001); this linear association remained significant even after full multivariate adjustment (P(trend) =0.041). Interestingly, in this fully adjusted model, long-term progression of abdominal obesity was the only component of the MetS significantly associated with increasing quartiles of baseline cystatin C levels (P(trend) =0.008). CONCLUSION: These findings suggest that cystatin C may adversely affect metabolic factors, particularly abdominal obesity, thus contributing to development of the MetS. Our results may help to explain the link between cystatin C and development of CVD. © 2013 The Association for the Publication of the Journal of Internal Medicine.}},
  author       = {{Magnusson, Martin and Hedblad, Bo and Engström, Gunnar and Persson, Magnus and Nilsson, Peter and Melander, Olle}},
  issn         = {{1365-2796}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{192--199}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Journal of Internal Medicine}},
  title        = {{High levels of cystatin C predict the metabolic syndrome: the prospective Malmö Diet and Cancer Study.}},
  url          = {{http://dx.doi.org/10.1111/joim.12051}},
  doi          = {{10.1111/joim.12051}},
  volume       = {{274}},
  year         = {{2013}},
}