Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Radiopaque FeNnN-Mo composite drawn filled tubing wires for braided absorbable neurovascular devices

Griebel, Adam ; Maier, Petra LU ; Summers, Henry ; Clausius, Benjamin ; Kanasty, Isabella ; He, Weilue ; Peterson, Nicholas ; Czerniak, Carolyn ; Oliver, Alexander A. and Kallmes, David F. , et al. (2024) In Bioactive Materials 40. p.74-87
Abstract
Flow diverter devices are small stents used to divert blood flow away from aneurysms in the brain, stagnating flow and inducing intra-aneurysmal thrombosis which in time will prevent aneurysm rupture. Current devices are formed from thin (∼25 μm) wires which will remain in place long after the aneurysm has been mitigated. As their continued presence could lead to secondary complications, an absorbable flow diverter which dissolves into the body after aneurysm occlusion is desirable. The absorbable metals investigated to date struggle to achieve the necessary combination of strength, elasticity, corrosion rate, fragmentation resistance, radiopacity, and biocompatibility. This work proposes and investigates a new composite wire concept... (More)
Flow diverter devices are small stents used to divert blood flow away from aneurysms in the brain, stagnating flow and inducing intra-aneurysmal thrombosis which in time will prevent aneurysm rupture. Current devices are formed from thin (∼25 μm) wires which will remain in place long after the aneurysm has been mitigated. As their continued presence could lead to secondary complications, an absorbable flow diverter which dissolves into the body after aneurysm occlusion is desirable. The absorbable metals investigated to date struggle to achieve the necessary combination of strength, elasticity, corrosion rate, fragmentation resistance, radiopacity, and biocompatibility. This work proposes and investigates a new composite wire concept combining absorbable iron alloy (FeMnN) shells with one or more pure molybdenum (Mo) cores. Various wire configurations are produced and drawn to 25–250 μm wires. Tensile testing revealed high and tunable mechanical properties on par with existing flow diverter materials. In vitro degradation testing of 100 μm wire in DMEM to 7 days indicated progressive corrosion and cracking of the FeMnN shell but not of the Mo, confirming the cathodic protection of the Mo by the FeMnN and thus mitigation of premature fragmentation risk. In vivo implantation and subsequent μCT of the same wires in mouse aortas to 6 months showed meaningful corrosion had begun in the FeMnN shell but not yet in the Mo filament cores. In total, these results indicate that these composites may offer an ideal combination of properties for absorbable flow diverters. (Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; ; ; and , et al. (More)
; ; ; ; ; ; ; ; ; ; ; and (Less)
publishing date
type
Contribution to journal
publication status
published
subject
in
Bioactive Materials
volume
40
pages
14 pages
publisher
KeAi Communications Co.
external identifiers
  • pmid:38962657
  • scopus:85195259696
ISSN
2452-199X
DOI
10.1016/j.bioactmat.2024.06.002
language
English
LU publication?
no
id
2ecff2f3-e59b-4834-b8e3-9722377df048
date added to LUP
2025-01-03 19:21:09
date last changed
2025-04-04 13:55:04
@article{2ecff2f3-e59b-4834-b8e3-9722377df048,
  abstract     = {{Flow diverter devices are small stents used to divert blood flow away from aneurysms in the brain, stagnating flow and inducing intra-aneurysmal thrombosis which in time will prevent aneurysm rupture. Current devices are formed from thin (∼25 μm) wires which will remain in place long after the aneurysm has been mitigated. As their continued presence could lead to secondary complications, an absorbable flow diverter which dissolves into the body after aneurysm occlusion is desirable. The absorbable metals investigated to date struggle to achieve the necessary combination of strength, elasticity, corrosion rate, fragmentation resistance, radiopacity, and biocompatibility. This work proposes and investigates a new composite wire concept combining absorbable iron alloy (FeMnN) shells with one or more pure molybdenum (Mo) cores. Various wire configurations are produced and drawn to 25–250 μm wires. Tensile testing revealed high and tunable mechanical properties on par with existing flow diverter materials. In vitro degradation testing of 100 μm wire in DMEM to 7 days indicated progressive corrosion and cracking of the FeMnN shell but not of the Mo, confirming the cathodic protection of the Mo by the FeMnN and thus mitigation of premature fragmentation risk. In vivo implantation and subsequent μCT of the same wires in mouse aortas to 6 months showed meaningful corrosion had begun in the FeMnN shell but not yet in the Mo filament cores. In total, these results indicate that these composites may offer an ideal combination of properties for absorbable flow diverters.}},
  author       = {{Griebel, Adam and Maier, Petra and Summers, Henry and Clausius, Benjamin and Kanasty, Isabella and He, Weilue and Peterson, Nicholas and Czerniak, Carolyn and Oliver, Alexander A. and Kallmes, David F. and Kadirvel, Ramanathan and Schaffer, Jeremy E. and Guillory II, Roger J.}},
  issn         = {{2452-199X}},
  language     = {{eng}},
  pages        = {{74--87}},
  publisher    = {{KeAi Communications Co.}},
  series       = {{Bioactive Materials}},
  title        = {{Radiopaque FeNnN-Mo composite drawn filled tubing wires for braided absorbable neurovascular devices}},
  url          = {{http://dx.doi.org/10.1016/j.bioactmat.2024.06.002}},
  doi          = {{10.1016/j.bioactmat.2024.06.002}},
  volume       = {{40}},
  year         = {{2024}},
}