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Predicting severe COVID-19 disease in adults : A single-centre cohort study during the first three pandemic waves in 2020–2021 in Vilnius, Lithuania

Kubiliute, Ieva ; Zaboras, Edgaras ; Majauskaite, Fausta ; Urboniene, Jurgita ; Zablockiene, Birute ; Gefenaite, Giedre LU orcid ; Mickiene, Aukse and Jancoriene, Ligita (2026) In PLOS ONE 21(5 May).
Abstract

Background Since its emergence, the COVID-19 infection has led to significant morbidity and mortality worldwide. Early identification of patients at risk for severe disease is essential for more effective triage, timely therapeutic intervention, and optimal resource allocation. Differences in population characteristics may contribute to variability in disease outcomes, which emphasizes the need for regional-level data, especially from underrepresented regions. The main aim of this study was to identify the demographic, clinical, and laboratory predictors of severe COVID-19, defined as the need for oxygen therapy, in Lithuania. Materials and methods We conducted an ambispective observational cohort study at Vilnius University Hospital... (More)

Background Since its emergence, the COVID-19 infection has led to significant morbidity and mortality worldwide. Early identification of patients at risk for severe disease is essential for more effective triage, timely therapeutic intervention, and optimal resource allocation. Differences in population characteristics may contribute to variability in disease outcomes, which emphasizes the need for regional-level data, especially from underrepresented regions. The main aim of this study was to identify the demographic, clinical, and laboratory predictors of severe COVID-19, defined as the need for oxygen therapy, in Lithuania. Materials and methods We conducted an ambispective observational cohort study at Vilnius University Hospital Santaros Klinikos in Vilnius, Lithuania, from March 2020 to December 2021. Adult patients with a confirmed diagnosis of COVID-19 and hospitalized longer than 24 hours were included in this study. Data were collected from the electronic medical records and patient interviews. To identify predictors of severe COVID-19 course, a multivariable binary logistic regression model was performed. Results Among 495 patients, 52.9% were male, the median age was 55 years, and 61.2% had at least one underlying condition. The most common symptoms on admission were malaise (77.1%), subfebrile fever (65.9%), and cough (69.7%). CRP demonstrated the highest predictive value for severe COVID-19 (AUC=0.84), followed by LDH (AUC=0.80). Older age (OR 1.04 per year, 95% CI 1.00–1.08), obesity (OR 3.55, 95% CI 1.35–9.30), lymphopenia (OR 3.70, 95% CI 1.37–9.99), higher LDH (OR 1.008, 95% CI 1.00–1.01) and CRP (OR 1.021, 95% CI 1.01–1.04) levels were identified as the strongest predictors for severe COVID-19 disease course. Conclusion Older age, obesity, lymphopenia, and higher CRP and LDH were associated with developing severe COVID-19 disease, indicating that combining patient history and laboratory parameters can provide a practical risk stratification approach to help clinicians identify high-risk patients early upon hospitalisation.

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author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
PLOS ONE
volume
21
issue
5 May
article number
e0350112
publisher
Public Library of Science (PLoS)
external identifiers
  • pmid:42213699
  • scopus:105040547894
ISSN
1932-6203
DOI
10.1371/journal.pone.0350112
project
Infectious diseases surveillance, vaccine effectiveness and determinants of acceptance
language
English
LU publication?
yes
additional info
Publisher Copyright: © 2026 Kubiliute et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
id
2ee73822-3f6e-41e9-94fa-d93642b3065e
date added to LUP
2026-07-23 11:11:44
date last changed
2026-09-03 14:27:27
@article{2ee73822-3f6e-41e9-94fa-d93642b3065e,
  abstract     = {{<p>Background Since its emergence, the COVID-19 infection has led to significant morbidity and mortality worldwide. Early identification of patients at risk for severe disease is essential for more effective triage, timely therapeutic intervention, and optimal resource allocation. Differences in population characteristics may contribute to variability in disease outcomes, which emphasizes the need for regional-level data, especially from underrepresented regions. The main aim of this study was to identify the demographic, clinical, and laboratory predictors of severe COVID-19, defined as the need for oxygen therapy, in Lithuania. Materials and methods We conducted an ambispective observational cohort study at Vilnius University Hospital Santaros Klinikos in Vilnius, Lithuania, from March 2020 to December 2021. Adult patients with a confirmed diagnosis of COVID-19 and hospitalized longer than 24 hours were included in this study. Data were collected from the electronic medical records and patient interviews. To identify predictors of severe COVID-19 course, a multivariable binary logistic regression model was performed. Results Among 495 patients, 52.9% were male, the median age was 55 years, and 61.2% had at least one underlying condition. The most common symptoms on admission were malaise (77.1%), subfebrile fever (65.9%), and cough (69.7%). CRP demonstrated the highest predictive value for severe COVID-19 (AUC=0.84), followed by LDH (AUC=0.80). Older age (OR 1.04 per year, 95% CI 1.00–1.08), obesity (OR 3.55, 95% CI 1.35–9.30), lymphopenia (OR 3.70, 95% CI 1.37–9.99), higher LDH (OR 1.008, 95% CI 1.00–1.01) and CRP (OR 1.021, 95% CI 1.01–1.04) levels were identified as the strongest predictors for severe COVID-19 disease course. Conclusion Older age, obesity, lymphopenia, and higher CRP and LDH were associated with developing severe COVID-19 disease, indicating that combining patient history and laboratory parameters can provide a practical risk stratification approach to help clinicians identify high-risk patients early upon hospitalisation.</p>}},
  author       = {{Kubiliute, Ieva and Zaboras, Edgaras and Majauskaite, Fausta and Urboniene, Jurgita and Zablockiene, Birute and Gefenaite, Giedre and Mickiene, Aukse and Jancoriene, Ligita}},
  issn         = {{1932-6203}},
  language     = {{eng}},
  number       = {{5 May}},
  publisher    = {{Public Library of Science (PLoS)}},
  series       = {{PLOS ONE}},
  title        = {{Predicting severe COVID-19 disease in adults : A single-centre cohort study during the first three pandemic waves in 2020–2021 in Vilnius, Lithuania}},
  url          = {{http://dx.doi.org/10.1371/journal.pone.0350112}},
  doi          = {{10.1371/journal.pone.0350112}},
  volume       = {{21}},
  year         = {{2026}},
}