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Effect of head posture on the healthy human carotid bifurcation hemodynamics

Papaharilaou, Yannis ; Aristokleous, Nicolas LU ; Seimenis, Ioannis ; Khozeymeh, Mohammad Iman ; Georgiou, Georgios C ; Brott, Brigitta C ; Eracleous, Elena and Anayiotos, Andreas S (2013) In Medical & Biological Engineering & Computing 51(1-2). p.18-207
Abstract

Head and neck postures may cause morphology changes to the geometry of the carotid bifurcation (CB) that alter the low and oscillating wall shear stress (WSS) regions previously reported as important in the development of atherosclerosis. Here the right and left CB were imaged by MRI in two healthy subjects in the neutral head posture with the subject in the supine position and in two other head postures with the subject in the prone position: (1) rightward rotation up to 80°, and (2) leftward rotation up to 80°. Image-based computational models were constructed to investigate the effect of posture on arterial geometry and local hemodynamics. The area exposure to unfavorable hemodynamics, based on thresholds set for oscillatory shear... (More)

Head and neck postures may cause morphology changes to the geometry of the carotid bifurcation (CB) that alter the low and oscillating wall shear stress (WSS) regions previously reported as important in the development of atherosclerosis. Here the right and left CB were imaged by MRI in two healthy subjects in the neutral head posture with the subject in the supine position and in two other head postures with the subject in the prone position: (1) rightward rotation up to 80°, and (2) leftward rotation up to 80°. Image-based computational models were constructed to investigate the effect of posture on arterial geometry and local hemodynamics. The area exposure to unfavorable hemodynamics, based on thresholds set for oscillatory shear index (OSI), WSS and relative residence time, was used to quantify the hemodynamic impact on the wall. Torsion of the head was found to: (1) cause notable changes in the bifurcation and internal carotid artery angles and, in most cases, on cross-sectional area ratios for common, internal and external carotid artery, (2) change the spatial distribution of wall regions exposed to unfavorable hemodynamics, and (3) cause a marked change in the hemodynamic burden on the wall when the OSI was considered. These findings suggest that head posture may be associated with the genesis and development of atherosclerotic disease as well as complications in stenotic and stented vessels.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Adult, Carotid Arteries/physiology, Head/blood supply, Health, Hemodynamics, Humans, Magnetic Resonance Imaging, Male, Posture/physiology, Time Factors
in
Medical & Biological Engineering & Computing
volume
51
issue
1-2
pages
12 pages
publisher
Springer
external identifiers
  • scopus:84874664467
  • pmid:23143389
ISSN
0140-0118
DOI
10.1007/s11517-012-0985-6
language
English
LU publication?
yes
id
2ef412a8-3b8d-4b0a-92f1-ef3edb733b30
date added to LUP
2019-05-14 09:30:04
date last changed
2020-01-16 03:54:08
@article{2ef412a8-3b8d-4b0a-92f1-ef3edb733b30,
  abstract     = {<p>Head and neck postures may cause morphology changes to the geometry of the carotid bifurcation (CB) that alter the low and oscillating wall shear stress (WSS) regions previously reported as important in the development of atherosclerosis. Here the right and left CB were imaged by MRI in two healthy subjects in the neutral head posture with the subject in the supine position and in two other head postures with the subject in the prone position: (1) rightward rotation up to 80°, and (2) leftward rotation up to 80°. Image-based computational models were constructed to investigate the effect of posture on arterial geometry and local hemodynamics. The area exposure to unfavorable hemodynamics, based on thresholds set for oscillatory shear index (OSI), WSS and relative residence time, was used to quantify the hemodynamic impact on the wall. Torsion of the head was found to: (1) cause notable changes in the bifurcation and internal carotid artery angles and, in most cases, on cross-sectional area ratios for common, internal and external carotid artery, (2) change the spatial distribution of wall regions exposed to unfavorable hemodynamics, and (3) cause a marked change in the hemodynamic burden on the wall when the OSI was considered. These findings suggest that head posture may be associated with the genesis and development of atherosclerotic disease as well as complications in stenotic and stented vessels.</p>},
  author       = {Papaharilaou, Yannis and Aristokleous, Nicolas and Seimenis, Ioannis and Khozeymeh, Mohammad Iman and Georgiou, Georgios C and Brott, Brigitta C and Eracleous, Elena and Anayiotos, Andreas S},
  issn         = {0140-0118},
  language     = {eng},
  number       = {1-2},
  pages        = {18--207},
  publisher    = {Springer},
  series       = {Medical & Biological Engineering & Computing},
  title        = {Effect of head posture on the healthy human carotid bifurcation hemodynamics},
  url          = {http://dx.doi.org/10.1007/s11517-012-0985-6},
  doi          = {10.1007/s11517-012-0985-6},
  volume       = {51},
  year         = {2013},
}