Advanced

In vivo comparative evaluation of hemodialysis tubing plasticized with DEHP and TEHTM

Christensson, A LU ; Ljunggren, L ; Nilsson-Thorell, C ; Arge, B ; Diehl, U ; Hagstam, K E and Lundberg, M (1991) In International Journal of Artificial Organs 14(7). p.10-407
Abstract

The migration of plasticizers from blood lines was studied in 11 patients with chronic renal failure on hemodialysis for a period of six months. Di-2-ethylhexylphthalate (DEHP), the conventional plasticizer, was compared with tri-2-ethylhexyltrimellitate (TEHTM). A liquid chromatography method for quantitative determination of DEHP and TEHTM in human blood plasma is described. During treatment with tubing containing DEHP, the plasma level of DEHP rose from 0.10 micrograms/ml (less than 0.05-0.17 n = 11) to 0.70 micrograms/ml (0.30-1.6 n = 11). When the patients were changed to tubing containing TEHTM, the concentration of DEHP was below or close to the detection limit and TEHTM could not be detected. No adverse events of either tubing... (More)

The migration of plasticizers from blood lines was studied in 11 patients with chronic renal failure on hemodialysis for a period of six months. Di-2-ethylhexylphthalate (DEHP), the conventional plasticizer, was compared with tri-2-ethylhexyltrimellitate (TEHTM). A liquid chromatography method for quantitative determination of DEHP and TEHTM in human blood plasma is described. During treatment with tubing containing DEHP, the plasma level of DEHP rose from 0.10 micrograms/ml (less than 0.05-0.17 n = 11) to 0.70 micrograms/ml (0.30-1.6 n = 11). When the patients were changed to tubing containing TEHTM, the concentration of DEHP was below or close to the detection limit and TEHTM could not be detected. No adverse events of either tubing were found as regards acute toxic effects, performance or applicability.

(Less)
Please use this url to cite or link to this publication:
author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Aged, Benzoates/analysis, Chromatography, Liquid, Diethylhexyl Phthalate/analysis, Female, Humans, Infant, Newborn, Kidney Failure, Chronic/therapy, Male, Plasticizers/analysis, Polyvinyl Chloride, Renal Dialysis/instrumentation
in
International Journal of Artificial Organs
volume
14
issue
7
pages
4 pages
publisher
Wichtig Editore - Milano (Italy)
external identifiers
  • pmid:1889893
  • scopus:0025819678
ISSN
0391-3988
DOI
10.1177/039139889101400705
language
English
LU publication?
no
id
2efe4f39-c347-43fa-9563-9545e8b5cdfb
date added to LUP
2019-05-16 14:10:20
date last changed
2019-05-20 13:29:06
@article{2efe4f39-c347-43fa-9563-9545e8b5cdfb,
  abstract     = {<p>The migration of plasticizers from blood lines was studied in 11 patients with chronic renal failure on hemodialysis for a period of six months. Di-2-ethylhexylphthalate (DEHP), the conventional plasticizer, was compared with tri-2-ethylhexyltrimellitate (TEHTM). A liquid chromatography method for quantitative determination of DEHP and TEHTM in human blood plasma is described. During treatment with tubing containing DEHP, the plasma level of DEHP rose from 0.10 micrograms/ml (less than 0.05-0.17 n = 11) to 0.70 micrograms/ml (0.30-1.6 n = 11). When the patients were changed to tubing containing TEHTM, the concentration of DEHP was below or close to the detection limit and TEHTM could not be detected. No adverse events of either tubing were found as regards acute toxic effects, performance or applicability.</p>},
  author       = {Christensson, A and Ljunggren, L and Nilsson-Thorell, C and Arge, B and Diehl, U and Hagstam, K E and Lundberg, M},
  issn         = {0391-3988},
  language     = {eng},
  number       = {7},
  pages        = {10--407},
  publisher    = {Wichtig Editore - Milano (Italy)},
  series       = {International Journal of Artificial Organs},
  title        = {In vivo comparative evaluation of hemodialysis tubing plasticized with DEHP and TEHTM},
  url          = {http://dx.doi.org/10.1177/039139889101400705},
  doi          = {10.1177/039139889101400705},
  volume       = {14},
  year         = {1991},
}