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Acute severe hepatitis of unknown etiology in children : A mini-review

Frediansyah, Andri ; Sallam, Malik LU ; Yufika, Amanda ; Sharun, Khan ; Iqhrammullah, Muhammad ; Chandran, Deepak ; Mamada, Sukamto S. ; Sallam, Dina E. ; Khader, Yousef and Lemu, Yohannes K. , et al. (2022) In Narra J 2(2).
Abstract

The emergence of acute, severe non hepA–E hepatitis of unknown etiology (ASHUE) has attracted global concern owing to the very young age of the patients and its unknown etiology. Although this condition has been linked to several possible causes, including viral infection, drugs and/or toxin exposure, the exact cause remains unknown; this makes treatment recommendation very difficult. In this review, we summarize recent updates on the clinical manifestations, complemented with laboratory results, case numbers with the global distribution and other epidemiological characteristics, and the possible etiologies. We also provide the proposed actions that could be undertaken to control and prevent further spread of this hepatitis. Since many... (More)

The emergence of acute, severe non hepA–E hepatitis of unknown etiology (ASHUE) has attracted global concern owing to the very young age of the patients and its unknown etiology. Although this condition has been linked to several possible causes, including viral infection, drugs and/or toxin exposure, the exact cause remains unknown; this makes treatment recommendation very difficult. In this review, we summarize recent updates on the clinical manifestations, complemented with laboratory results, case numbers with the global distribution and other epidemiological characteristics, and the possible etiologies. We also provide the proposed actions that could be undertaken to control and prevent further spread of this hepatitis. Since many etiological and pathological aspects of the acute non hepA-E hepatitis remain unclear, further research is needed to minimize the severe impact of this disease.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Acute non hepA–E hepatitis, clinical manifestations, epidemiological characteristics, outbreak, prevention
in
Narra J
volume
2
issue
2
article number
e83
publisher
Narra Sains Indonesia
external identifiers
  • scopus:85145942835
ISSN
2807-2618
DOI
10.52225/narra.v2i2.83
language
English
LU publication?
yes
additional info
Publisher Copyright: © 2022, School of Medicine, Universitas Syiah Kuala. All rights reserved.
id
2f11233e-6f2e-43d1-8cc1-e547371833bc
date added to LUP
2024-10-16 09:43:53
date last changed
2024-10-16 12:23:37
@article{2f11233e-6f2e-43d1-8cc1-e547371833bc,
  abstract     = {{<p>The emergence of acute, severe non hepA–E hepatitis of unknown etiology (ASHUE) has attracted global concern owing to the very young age of the patients and its unknown etiology. Although this condition has been linked to several possible causes, including viral infection, drugs and/or toxin exposure, the exact cause remains unknown; this makes treatment recommendation very difficult. In this review, we summarize recent updates on the clinical manifestations, complemented with laboratory results, case numbers with the global distribution and other epidemiological characteristics, and the possible etiologies. We also provide the proposed actions that could be undertaken to control and prevent further spread of this hepatitis. Since many etiological and pathological aspects of the acute non hepA-E hepatitis remain unclear, further research is needed to minimize the severe impact of this disease.</p>}},
  author       = {{Frediansyah, Andri and Sallam, Malik and Yufika, Amanda and Sharun, Khan and Iqhrammullah, Muhammad and Chandran, Deepak and Mamada, Sukamto S. and Sallam, Dina E. and Khader, Yousef and Lemu, Yohannes K. and Yusuf, Fauzi and Kretchy, James Paul and Abdeen, Ziad and Torres-Roman, J. Smith and Acharya, Yogesh and Bondarenko, Anastasia and Ikram, Aamer and Jamil, Kurnia F. and Kotfis, Katarzyna and Koyanagi, Ai and Smith, Lee and Megawati, Dewi and Rademaker, Marius and Emran, Talha B. and Memish, Ziad A. and Vento, Sandro and Nainu, Firzan and Harapan, Harapan}},
  issn         = {{2807-2618}},
  keywords     = {{Acute non hepA–E hepatitis; clinical manifestations; epidemiological characteristics; outbreak; prevention}},
  language     = {{eng}},
  number       = {{2}},
  publisher    = {{Narra Sains Indonesia}},
  series       = {{Narra J}},
  title        = {{Acute severe hepatitis of unknown etiology in children : A mini-review}},
  url          = {{http://dx.doi.org/10.52225/narra.v2i2.83}},
  doi          = {{10.52225/narra.v2i2.83}},
  volume       = {{2}},
  year         = {{2022}},
}