Biomarkers Predictive of Distant Disease-free Survival Derived from Diffusion-weighted Imaging of Breast Cancer
(2023) In Magnetic Resonance in Medical Sciences 22(4). p.469-476- Abstract
Purpose: To investigate whether intravoxel incoherent motion (IVIM) and/or non-Gaussian diffusion parameters are associated with distant disease-free survival (DDFS) in patients with invasive breast cancer. Methods: From May 2013 to March 2015, 101 patients (mean age 60.0, range 28–88) with invasive breast cancer were evaluated prospectively. IVIM parameters (flowing blood volume fraction [fIVIM] and pseudodiffusion coefficient [D*]) and non-Gaussian diffusion parameters (theoretical apparent diffusion coefficient [ADC] at a b value of 0 s/mm2 [ADC0 ] and kurtosis [K]) were estimated using a diffusionweighted imaging series of 16 b values up to 2500 s/mm2. Shifted ADC values... (More)
Purpose: To investigate whether intravoxel incoherent motion (IVIM) and/or non-Gaussian diffusion parameters are associated with distant disease-free survival (DDFS) in patients with invasive breast cancer. Methods: From May 2013 to March 2015, 101 patients (mean age 60.0, range 28–88) with invasive breast cancer were evaluated prospectively. IVIM parameters (flowing blood volume fraction [fIVIM] and pseudodiffusion coefficient [D*]) and non-Gaussian diffusion parameters (theoretical apparent diffusion coefficient [ADC] at a b value of 0 s/mm2 [ADC0 ] and kurtosis [K]) were estimated using a diffusionweighted imaging series of 16 b values up to 2500 s/mm2. Shifted ADC values (sADC200–1500) and standard ADC values (ADC0–800) were also calculated. The Kaplan–Meier method was used to generate survival analyses for DDFS, which were compared using the log-rank test. Univariable Cox proportional hazards models were used to assess any associations between each parameter and distant metastasis-free survival. Results: The median observation period was 80 months (range, 35–92 months). Among the 101 patients, 12 (11.9%) developed distant metastasis, with a median time to metastasis of 79 months (range, 10–92 months). Kaplan–Meier analysis showed that DDFS was significantly shorter in patients with K > 0.98 than in those with K ≤ 0.98 (P = 0.04). Cox regression analysis showed a marginal statistical association between K and distant metastasis-free survival (P = 0.05). Conclusion: Non-Gaussian diffusion may be associated with prognosis in invasive breast cancer. A higher K may be a marker to help identify patients at an elevated risk of distant metastasis, which could guide subsequent treatment.
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- author
- Honda, Maya ; Iima, Mami ; Kataoka, Masako ; Fukushima, Yasuhiro ; Ota, Rie ; Ohashi, Akane LU ; Toi, Masakazu and Nakamoto, Yuji
- organization
- publishing date
- 2023
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- breast neoplasms, diffusion-weighted magnetic resonance imaging, intravoxel incoherent motion, kurtosis, prognosis
- in
- Magnetic Resonance in Medical Sciences
- volume
- 22
- issue
- 4
- pages
- 8 pages
- publisher
- Japan Society of Magnetic Resonance in Medicine
- external identifiers
-
- pmid:35922924
- scopus:85173578522
- ISSN
- 1347-3182
- DOI
- 10.2463/mrms.mp.2022-0060
- language
- English
- LU publication?
- yes
- id
- 2f207c1b-69a8-46e2-8b71-52b8b548da9b
- date added to LUP
- 2023-12-06 13:26:21
- date last changed
- 2024-04-19 08:01:24
@article{2f207c1b-69a8-46e2-8b71-52b8b548da9b, abstract = {{<p>Purpose: To investigate whether intravoxel incoherent motion (IVIM) and/or non-Gaussian diffusion parameters are associated with distant disease-free survival (DDFS) in patients with invasive breast cancer. Methods: From May 2013 to March 2015, 101 patients (mean age 60.0, range 28–88) with invasive breast cancer were evaluated prospectively. IVIM parameters (flowing blood volume fraction [f<sub>IVIM</sub>] and pseudodiffusion coefficient [D*]) and non-Gaussian diffusion parameters (theoretical apparent diffusion coefficient [ADC] at a b value of 0 s/mm<sup>2</sup> [ADC<sub>0</sub> ] and kurtosis [K]) were estimated using a diffusionweighted imaging series of 16 b values up to 2500 s/mm<sup>2</sup>. Shifted ADC values (sADC<sub>200–1500</sub>) and standard ADC values (ADC<sub>0–800</sub>) were also calculated. The Kaplan–Meier method was used to generate survival analyses for DDFS, which were compared using the log-rank test. Univariable Cox proportional hazards models were used to assess any associations between each parameter and distant metastasis-free survival. Results: The median observation period was 80 months (range, 35–92 months). Among the 101 patients, 12 (11.9%) developed distant metastasis, with a median time to metastasis of 79 months (range, 10–92 months). Kaplan–Meier analysis showed that DDFS was significantly shorter in patients with K > 0.98 than in those with K ≤ 0.98 (P = 0.04). Cox regression analysis showed a marginal statistical association between K and distant metastasis-free survival (P = 0.05). Conclusion: Non-Gaussian diffusion may be associated with prognosis in invasive breast cancer. A higher K may be a marker to help identify patients at an elevated risk of distant metastasis, which could guide subsequent treatment.</p>}}, author = {{Honda, Maya and Iima, Mami and Kataoka, Masako and Fukushima, Yasuhiro and Ota, Rie and Ohashi, Akane and Toi, Masakazu and Nakamoto, Yuji}}, issn = {{1347-3182}}, keywords = {{breast neoplasms; diffusion-weighted magnetic resonance imaging; intravoxel incoherent motion; kurtosis; prognosis}}, language = {{eng}}, number = {{4}}, pages = {{469--476}}, publisher = {{Japan Society of Magnetic Resonance in Medicine}}, series = {{Magnetic Resonance in Medical Sciences}}, title = {{Biomarkers Predictive of Distant Disease-free Survival Derived from Diffusion-weighted Imaging of Breast Cancer}}, url = {{http://dx.doi.org/10.2463/mrms.mp.2022-0060}}, doi = {{10.2463/mrms.mp.2022-0060}}, volume = {{22}}, year = {{2023}}, }