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Biomarkers Predictive of Distant Disease-free Survival Derived from Diffusion-weighted Imaging of Breast Cancer

Honda, Maya ; Iima, Mami ; Kataoka, Masako ; Fukushima, Yasuhiro ; Ota, Rie ; Ohashi, Akane LU ; Toi, Masakazu and Nakamoto, Yuji (2023) In Magnetic Resonance in Medical Sciences 22(4). p.469-476
Abstract

Purpose: To investigate whether intravoxel incoherent motion (IVIM) and/or non-Gaussian diffusion parameters are associated with distant disease-free survival (DDFS) in patients with invasive breast cancer. Methods: From May 2013 to March 2015, 101 patients (mean age 60.0, range 28–88) with invasive breast cancer were evaluated prospectively. IVIM parameters (flowing blood volume fraction [fIVIM] and pseudodiffusion coefficient [D*]) and non-Gaussian diffusion parameters (theoretical apparent diffusion coefficient [ADC] at a b value of 0 s/mm2 [ADC0 ] and kurtosis [K]) were estimated using a diffusionweighted imaging series of 16 b values up to 2500 s/mm2. Shifted ADC values... (More)

Purpose: To investigate whether intravoxel incoherent motion (IVIM) and/or non-Gaussian diffusion parameters are associated with distant disease-free survival (DDFS) in patients with invasive breast cancer. Methods: From May 2013 to March 2015, 101 patients (mean age 60.0, range 28–88) with invasive breast cancer were evaluated prospectively. IVIM parameters (flowing blood volume fraction [fIVIM] and pseudodiffusion coefficient [D*]) and non-Gaussian diffusion parameters (theoretical apparent diffusion coefficient [ADC] at a b value of 0 s/mm2 [ADC0 ] and kurtosis [K]) were estimated using a diffusionweighted imaging series of 16 b values up to 2500 s/mm2. Shifted ADC values (sADC200–1500) and standard ADC values (ADC0–800) were also calculated. The Kaplan–Meier method was used to generate survival analyses for DDFS, which were compared using the log-rank test. Univariable Cox proportional hazards models were used to assess any associations between each parameter and distant metastasis-free survival. Results: The median observation period was 80 months (range, 35–92 months). Among the 101 patients, 12 (11.9%) developed distant metastasis, with a median time to metastasis of 79 months (range, 10–92 months). Kaplan–Meier analysis showed that DDFS was significantly shorter in patients with K > 0.98 than in those with K ≤ 0.98 (P = 0.04). Cox regression analysis showed a marginal statistical association between K and distant metastasis-free survival (P = 0.05). Conclusion: Non-Gaussian diffusion may be associated with prognosis in invasive breast cancer. A higher K may be a marker to help identify patients at an elevated risk of distant metastasis, which could guide subsequent treatment.

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author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
breast neoplasms, diffusion-weighted magnetic resonance imaging, intravoxel incoherent motion, kurtosis, prognosis
in
Magnetic Resonance in Medical Sciences
volume
22
issue
4
pages
8 pages
publisher
Japan Society of Magnetic Resonance in Medicine
external identifiers
  • pmid:35922924
  • scopus:85173578522
ISSN
1347-3182
DOI
10.2463/mrms.mp.2022-0060
language
English
LU publication?
yes
id
2f207c1b-69a8-46e2-8b71-52b8b548da9b
date added to LUP
2023-12-06 13:26:21
date last changed
2024-04-19 08:01:24
@article{2f207c1b-69a8-46e2-8b71-52b8b548da9b,
  abstract     = {{<p>Purpose: To investigate whether intravoxel incoherent motion (IVIM) and/or non-Gaussian diffusion parameters are associated with distant disease-free survival (DDFS) in patients with invasive breast cancer. Methods: From May 2013 to March 2015, 101 patients (mean age 60.0, range 28–88) with invasive breast cancer were evaluated prospectively. IVIM parameters (flowing blood volume fraction [f<sub>IVIM</sub>] and pseudodiffusion coefficient [D*]) and non-Gaussian diffusion parameters (theoretical apparent diffusion coefficient [ADC] at a b value of 0 s/mm<sup>2</sup> [ADC<sub>0</sub> ] and kurtosis [K]) were estimated using a diffusionweighted imaging series of 16 b values up to 2500 s/mm<sup>2</sup>. Shifted ADC values (sADC<sub>200–1500</sub>) and standard ADC values (ADC<sub>0–800</sub>) were also calculated. The Kaplan–Meier method was used to generate survival analyses for DDFS, which were compared using the log-rank test. Univariable Cox proportional hazards models were used to assess any associations between each parameter and distant metastasis-free survival. Results: The median observation period was 80 months (range, 35–92 months). Among the 101 patients, 12 (11.9%) developed distant metastasis, with a median time to metastasis of 79 months (range, 10–92 months). Kaplan–Meier analysis showed that DDFS was significantly shorter in patients with K &gt; 0.98 than in those with K ≤ 0.98 (P = 0.04). Cox regression analysis showed a marginal statistical association between K and distant metastasis-free survival (P = 0.05). Conclusion: Non-Gaussian diffusion may be associated with prognosis in invasive breast cancer. A higher K may be a marker to help identify patients at an elevated risk of distant metastasis, which could guide subsequent treatment.</p>}},
  author       = {{Honda, Maya and Iima, Mami and Kataoka, Masako and Fukushima, Yasuhiro and Ota, Rie and Ohashi, Akane and Toi, Masakazu and Nakamoto, Yuji}},
  issn         = {{1347-3182}},
  keywords     = {{breast neoplasms; diffusion-weighted magnetic resonance imaging; intravoxel incoherent motion; kurtosis; prognosis}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{469--476}},
  publisher    = {{Japan Society of Magnetic Resonance in Medicine}},
  series       = {{Magnetic Resonance in Medical Sciences}},
  title        = {{Biomarkers Predictive of Distant Disease-free Survival Derived from Diffusion-weighted Imaging of Breast Cancer}},
  url          = {{http://dx.doi.org/10.2463/mrms.mp.2022-0060}},
  doi          = {{10.2463/mrms.mp.2022-0060}},
  volume       = {{22}},
  year         = {{2023}},
}