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Scanning Compton X-ray microscopy

Villanueva-Perez, P. LU orcid ; Fleckenstein, H. ; Prasciolu, M. ; Murray, K. T. ; Domaracky, M. ; Gregoric, K. ; Mariani, V. ; Gelisio, L. ; Kuhn, M. and Hannappel, J. , et al. (2021) In Optics Letters 46(8). p.1920-1923
Abstract

X-ray microscopy offers the opportunity to image biological and radiosensitive materials without special sample preparations, bridging optical and electron microscopy capabilities. However, the performance of such microscopes, when imaging radiosensitive samples, is not limited by their intrinsic resolution, but by the radiation damage induced on such samples. Here, we demonstrate a novel, to the best of our knowledge, radio-efficient microscope, scanning Compton X-ray microscopy (SCXM), which uses coherently and incoherently (Compton) scattered photons to minimize the deposited energy per unit of mass for a given imaging signal. We implemented SCXM, using lenses capable of efficiently focusing 60 keV X-ray photons into the... (More)

X-ray microscopy offers the opportunity to image biological and radiosensitive materials without special sample preparations, bridging optical and electron microscopy capabilities. However, the performance of such microscopes, when imaging radiosensitive samples, is not limited by their intrinsic resolution, but by the radiation damage induced on such samples. Here, we demonstrate a novel, to the best of our knowledge, radio-efficient microscope, scanning Compton X-ray microscopy (SCXM), which uses coherently and incoherently (Compton) scattered photons to minimize the deposited energy per unit of mass for a given imaging signal. We implemented SCXM, using lenses capable of efficiently focusing 60 keV X-ray photons into the sub-micrometer scale, and probe its radio-efficient capabilities. SCXM, when implemented in high-energy diffraction-limited storage rings, e.g., European Synchrotron Radiation Facility Extremely Brilliant Source and PETRA IV, will open the opportunity to explore the nanoscale of unstained, unsectioned, and undamaged radiosensitive materials.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Optics Letters
volume
46
issue
8
pages
4 pages
publisher
Optical Society of America
external identifiers
  • scopus:85104473554
  • pmid:33857104
ISSN
0146-9592
DOI
10.1364/OL.421232
language
English
LU publication?
yes
id
2f9c676d-d750-4f65-81c6-c2c49e46aa92
date added to LUP
2022-03-09 16:38:46
date last changed
2024-11-29 05:58:07
@article{2f9c676d-d750-4f65-81c6-c2c49e46aa92,
  abstract     = {{<p>X-ray microscopy offers the opportunity to image biological and radiosensitive materials without special sample preparations, bridging optical and electron microscopy capabilities. However, the performance of such microscopes, when imaging radiosensitive samples, is not limited by their intrinsic resolution, but by the radiation damage induced on such samples. Here, we demonstrate a novel, to the best of our knowledge, radio-efficient microscope, scanning Compton X-ray microscopy (SCXM), which uses coherently and incoherently (Compton) scattered photons to minimize the deposited energy per unit of mass for a given imaging signal. We implemented SCXM, using lenses capable of efficiently focusing 60 keV X-ray photons into the sub-micrometer scale, and probe its radio-efficient capabilities. SCXM, when implemented in high-energy diffraction-limited storage rings, e.g., European Synchrotron Radiation Facility Extremely Brilliant Source and PETRA IV, will open the opportunity to explore the nanoscale of unstained, unsectioned, and undamaged radiosensitive materials.</p>}},
  author       = {{Villanueva-Perez, P. and Fleckenstein, H. and Prasciolu, M. and Murray, K. T. and Domaracky, M. and Gregoric, K. and Mariani, V. and Gelisio, L. and Kuhn, M. and Hannappel, J. and Yefanov, O. and Ivanov, N. and Sarrou, I. and Pennicard, D. and Becker, J. and Zimmermann, M. Von and Gutowski, O. and Dippel, A. C. and Chapman, H. N. and Bajt, S.}},
  issn         = {{0146-9592}},
  language     = {{eng}},
  month        = {{04}},
  number       = {{8}},
  pages        = {{1920--1923}},
  publisher    = {{Optical Society of America}},
  series       = {{Optics Letters}},
  title        = {{Scanning Compton X-ray microscopy}},
  url          = {{http://dx.doi.org/10.1364/OL.421232}},
  doi          = {{10.1364/OL.421232}},
  volume       = {{46}},
  year         = {{2021}},
}