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U-EPX levels and wheezing in infants and young children with and without RSV bronchiolitis

Kristjansson, S; Wennergren, David LU ; Eriksson, B; Thorarinsdottir, H and Wennergren, G (2006) In Respiratory Medicine 100(5). p.878-883
Abstract
An association between severe infant bronchiolitis due to respiratory syncytial virus (RSV) and subsequent wheezing is well documented. High levels of urinary eosinophil protein X (U-EPX) have been related to active disease in asthmatic children. The aim of this study was to analyse whether RSV bronchiolitis leads to an increase in U-EPX levels and whether wheezing is more common in children with high U-EPX values. Seventeen infants requiring in-ward care for verified RSV tower respiratory tract infection were followed and compared with age-matched controls. A reference group without a history of RSV bronchiolitis was also included. At inclusion at mean age 3.3 months and at follow-up at mean age 32.9 months, U-EPX levels were comparable... (More)
An association between severe infant bronchiolitis due to respiratory syncytial virus (RSV) and subsequent wheezing is well documented. High levels of urinary eosinophil protein X (U-EPX) have been related to active disease in asthmatic children. The aim of this study was to analyse whether RSV bronchiolitis leads to an increase in U-EPX levels and whether wheezing is more common in children with high U-EPX values. Seventeen infants requiring in-ward care for verified RSV tower respiratory tract infection were followed and compared with age-matched controls. A reference group without a history of RSV bronchiolitis was also included. At inclusion at mean age 3.3 months and at follow-up at mean age 32.9 months, U-EPX levels were comparable in the RSV group. However, at follow-up at mean age 6.4 months, the RSV group had significantly increased levels of U-EPX compared with inclusion (median 167.8; range 46.2-470.7 vs. 122.8; 43.7-266.0 mu g/mmol creatinine; P = 0.023) and also significantly increased compared with the 6-month-old controls (167.8 vs. 93.0; 19.0-204.0 mu g/mmol creatinine; P = 0.0095). RSV infected subjects that experienced wheezing had significantly higher U-EPX values both at inclusion and at age 32.9 months than those who did not. Also, in the reference group (mean age 18.4 months), the children who had wheezed during the preceding year had higher U-EPX levels than those who had not wheezed. In conclusion, RSV bronchiolitis severe enough to require in-ward care produces a significant, but transient increase in U-EPX. Furthermore, a high U-EPX at baseline appears to be associated with an increased risk of future wheezing. (c) 2005 Elsevier Ltd. All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
wheezing, respiratory syncytial virus, infant, EPX, asthma, bronchiolitis
in
Respiratory Medicine
volume
100
issue
5
pages
878 - 883
publisher
Elsevier
external identifiers
  • wos:000237093500015
  • scopus:33645880414
ISSN
1532-3064
DOI
10.1016/j.rmed.2005.08.013
language
English
LU publication?
yes
id
2fae1e9b-301f-4faf-9675-2c297753c421 (old id 410661)
date added to LUP
2007-10-08 08:37:57
date last changed
2019-02-20 07:34:10
@article{2fae1e9b-301f-4faf-9675-2c297753c421,
  abstract     = {An association between severe infant bronchiolitis due to respiratory syncytial virus (RSV) and subsequent wheezing is well documented. High levels of urinary eosinophil protein X (U-EPX) have been related to active disease in asthmatic children. The aim of this study was to analyse whether RSV bronchiolitis leads to an increase in U-EPX levels and whether wheezing is more common in children with high U-EPX values. Seventeen infants requiring in-ward care for verified RSV tower respiratory tract infection were followed and compared with age-matched controls. A reference group without a history of RSV bronchiolitis was also included. At inclusion at mean age 3.3 months and at follow-up at mean age 32.9 months, U-EPX levels were comparable in the RSV group. However, at follow-up at mean age 6.4 months, the RSV group had significantly increased levels of U-EPX compared with inclusion (median 167.8; range 46.2-470.7 vs. 122.8; 43.7-266.0 mu g/mmol creatinine; P = 0.023) and also significantly increased compared with the 6-month-old controls (167.8 vs. 93.0; 19.0-204.0 mu g/mmol creatinine; P = 0.0095). RSV infected subjects that experienced wheezing had significantly higher U-EPX values both at inclusion and at age 32.9 months than those who did not. Also, in the reference group (mean age 18.4 months), the children who had wheezed during the preceding year had higher U-EPX levels than those who had not wheezed. In conclusion, RSV bronchiolitis severe enough to require in-ward care produces a significant, but transient increase in U-EPX. Furthermore, a high U-EPX at baseline appears to be associated with an increased risk of future wheezing. (c) 2005 Elsevier Ltd. All rights reserved.},
  author       = {Kristjansson, S and Wennergren, David and Eriksson, B and Thorarinsdottir, H and Wennergren, G},
  issn         = {1532-3064},
  keyword      = {wheezing,respiratory syncytial virus,infant,EPX,asthma,bronchiolitis},
  language     = {eng},
  number       = {5},
  pages        = {878--883},
  publisher    = {Elsevier},
  series       = {Respiratory Medicine},
  title        = {U-EPX levels and wheezing in infants and young children with and without RSV bronchiolitis},
  url          = {http://dx.doi.org/10.1016/j.rmed.2005.08.013},
  volume       = {100},
  year         = {2006},
}