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PPARdelta mediates IL15 metabolic actions in myotubes : effects of hyperthermia

Fuster, Gemma; Busquets, Sílvia; Figueras, Maite; Ametller, Elisabet; Fontes Oliveira, Cibely LU ; Oliván, Mireia; Grimaldi, Paul A; Argilés, Josep M and López-Soriano, Francisco J (2009) In International Journal of Molecular Medicine 24(1). p.8-63
Abstract

C2C12 cells exposed to hyperthermia (41 degrees C) experienced an increase in both protein synthesis and degradation. The addition of IL15 under hyperthermic conditions resulted in an important increase in protein synthesis with no changes in protein degradation, except when cells overexpressed PPARdelta. The PPARdelta agonist GW501516 exerted similar effects on protein synthesis to IL15. Expression of a mutant dominant negative form of PPARdelta prevented the effect of the cytokine on protein synthesis, suggesting that this transcription factor is involved in the anabolic action of IL15. The present study also suggests that the effects of IL15 on lipid oxidation could be mediated by PPARdelta.

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author
publishing date
type
Contribution to journal
publication status
published
keywords
Animals, Cell Line, Hot Temperature, Interleukin-15, Mice, Muscle Fibers, Skeletal, Muscle, Skeletal, Mutation, PPAR delta, Protein Biosynthesis, Thiazoles, Journal Article, Research Support, Non-U.S. Gov't
in
International Journal of Molecular Medicine
volume
24
issue
1
pages
6 pages
publisher
D.A. Spandidos
external identifiers
  • scopus:67649531209
ISSN
1107-3756
language
English
LU publication?
no
id
2fae2e29-288c-435e-871b-c4b29bc3dfd5
date added to LUP
2017-02-28 16:19:19
date last changed
2017-09-24 05:08:10
@article{2fae2e29-288c-435e-871b-c4b29bc3dfd5,
  abstract     = {<p>C2C12 cells exposed to hyperthermia (41 degrees C) experienced an increase in both protein synthesis and degradation. The addition of IL15 under hyperthermic conditions resulted in an important increase in protein synthesis with no changes in protein degradation, except when cells overexpressed PPARdelta. The PPARdelta agonist GW501516 exerted similar effects on protein synthesis to IL15. Expression of a mutant dominant negative form of PPARdelta prevented the effect of the cytokine on protein synthesis, suggesting that this transcription factor is involved in the anabolic action of IL15. The present study also suggests that the effects of IL15 on lipid oxidation could be mediated by PPARdelta.</p>},
  author       = {Fuster, Gemma and Busquets, Sílvia and Figueras, Maite and Ametller, Elisabet and Fontes Oliveira, Cibely and Oliván, Mireia and Grimaldi, Paul A and Argilés, Josep M and López-Soriano, Francisco J},
  issn         = {1107-3756},
  keyword      = {Animals,Cell Line,Hot Temperature,Interleukin-15,Mice,Muscle Fibers, Skeletal,Muscle, Skeletal,Mutation,PPAR delta,Protein Biosynthesis,Thiazoles,Journal Article,Research Support, Non-U.S. Gov't},
  language     = {eng},
  number       = {1},
  pages        = {8--63},
  publisher    = {D.A. Spandidos},
  series       = {International Journal of Molecular Medicine},
  title        = {PPARdelta mediates IL15 metabolic actions in myotubes : effects of hyperthermia},
  volume       = {24},
  year         = {2009},
}