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Circulating Markers of Neutrophil Extracellular Traps (NETs) in Patients With Ovarian Tumors

Dobilas, Arturas LU ; Thalin, Charlotte ; Wallen, Hakan and Borgfeldt, Christer LU (2022) In Anticancer research 42(2). p.965-971
Abstract

BACKGROUND/AIM: Inflammation is a hallmark of cancer, and the role of neutrophils and neutrophil extracellular traps (NETs) in cancer and cancer-associated thrombosis has attracted a lot of interest. The NET-specific marker H3Cit has been found to be elevated in the plasma of patients with malignancies, suggesting NETs markers as novel cancer biomarkers. This study aimed to determine the levels of NETs markers (H3Cit and dsDNA) in the plasma of women with adnexal masses. PATIENTS AND METHODS: Peripheral blood samples were obtained from 199 patients admitted for primary surgery of adnexal masses. Patients were grouped according to tumor type and stage. Plasma levels of H3Cit-DNA, dsDNA, and CA125 were quantified. RESULTS: Plasma levels... (More)

BACKGROUND/AIM: Inflammation is a hallmark of cancer, and the role of neutrophils and neutrophil extracellular traps (NETs) in cancer and cancer-associated thrombosis has attracted a lot of interest. The NET-specific marker H3Cit has been found to be elevated in the plasma of patients with malignancies, suggesting NETs markers as novel cancer biomarkers. This study aimed to determine the levels of NETs markers (H3Cit and dsDNA) in the plasma of women with adnexal masses. PATIENTS AND METHODS: Peripheral blood samples were obtained from 199 patients admitted for primary surgery of adnexal masses. Patients were grouped according to tumor type and stage. Plasma levels of H3Cit-DNA, dsDNA, and CA125 were quantified. RESULTS: Plasma levels of H3Cit-DNA and dsDNA were not elevated in women with borderline or malignant ovarian tumors compared with those of the benign group. Increased levels of CA125 were found in the borderline and ovarian cancer group (ptrend<0.001). In Cox regression analysis, CA125 levels dichotomized at 326 IU/ml (median) were associated with worse overall survival (HR=1.9; 95%CI=1.03-3.36; p=0.038). No differences were found in the survival analyses of malignant ovarian tumors by analyzing the dsDNA and H3Cit-DNA levels. CONCLUSION: There is no association between NETs markers and ovarian tumors.

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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
dsDNA, H3Cit-DNA, NETs, Ovarian cancer, tumor marker
in
Anticancer research
volume
42
issue
2
pages
7 pages
publisher
International Institute of Cancer Research
external identifiers
  • scopus:85123905997
  • pmid:35093896
ISSN
1791-7530
DOI
10.21873/anticanres.15556
language
English
LU publication?
yes
id
2fbfd3f3-9fdb-4cc6-b4d4-89bc33fffcf2
date added to LUP
2022-04-06 12:33:16
date last changed
2024-04-24 18:55:32
@article{2fbfd3f3-9fdb-4cc6-b4d4-89bc33fffcf2,
  abstract     = {{<p>BACKGROUND/AIM: Inflammation is a hallmark of cancer, and the role of neutrophils and neutrophil extracellular traps (NETs) in cancer and cancer-associated thrombosis has attracted a lot of interest. The NET-specific marker H3Cit has been found to be elevated in the plasma of patients with malignancies, suggesting NETs markers as novel cancer biomarkers. This study aimed to determine the levels of NETs markers (H3Cit and dsDNA) in the plasma of women with adnexal masses. PATIENTS AND METHODS: Peripheral blood samples were obtained from 199 patients admitted for primary surgery of adnexal masses. Patients were grouped according to tumor type and stage. Plasma levels of H3Cit-DNA, dsDNA, and CA125 were quantified. RESULTS: Plasma levels of H3Cit-DNA and dsDNA were not elevated in women with borderline or malignant ovarian tumors compared with those of the benign group. Increased levels of CA125 were found in the borderline and ovarian cancer group (ptrend&lt;0.001). In Cox regression analysis, CA125 levels dichotomized at 326 IU/ml (median) were associated with worse overall survival (HR=1.9; 95%CI=1.03-3.36; p=0.038). No differences were found in the survival analyses of malignant ovarian tumors by analyzing the dsDNA and H3Cit-DNA levels. CONCLUSION: There is no association between NETs markers and ovarian tumors.</p>}},
  author       = {{Dobilas, Arturas and Thalin, Charlotte and Wallen, Hakan and Borgfeldt, Christer}},
  issn         = {{1791-7530}},
  keywords     = {{dsDNA; H3Cit-DNA; NETs; Ovarian cancer; tumor marker}},
  language     = {{eng}},
  month        = {{02}},
  number       = {{2}},
  pages        = {{965--971}},
  publisher    = {{International Institute of Cancer Research}},
  series       = {{Anticancer research}},
  title        = {{Circulating Markers of Neutrophil Extracellular Traps (NETs) in Patients With Ovarian Tumors}},
  url          = {{http://dx.doi.org/10.21873/anticanres.15556}},
  doi          = {{10.21873/anticanres.15556}},
  volume       = {{42}},
  year         = {{2022}},
}