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Familial risk of sleep-disordered breathing

Lundkvist, Karin; Sundquist, Kristina LU ; Li, Xinjun LU and Friberg, Danielle (2012) In Sleep Medicine 13(6). p.668-673
Abstract
Objective: To estimate the incidence of hospitalization for paediatric obstructive sleep apnoea syndrome (OSAS) or sleep-disordered breathing (SDB) caused by adenotonsillar or tonsillar hypertrophy without infection in children with a parent affected by OSAS. Patients and methods: Using the MigMed database at Lund University, hospital data on all children aged 0-18 years in Sweden between 1997 and 2007 (total of 3 million individuals) were used to identify all first hospital admissions for OSAS or either adenotonsillar or tonsillar hypertrophy. Next, individuals were categorized as either having or not having a parent affected by OSAS. Standardized incidence ratios (SIRs) with 95% confidence intervals (CIs) were estimated for boys and... (More)
Objective: To estimate the incidence of hospitalization for paediatric obstructive sleep apnoea syndrome (OSAS) or sleep-disordered breathing (SDB) caused by adenotonsillar or tonsillar hypertrophy without infection in children with a parent affected by OSAS. Patients and methods: Using the MigMed database at Lund University, hospital data on all children aged 0-18 years in Sweden between 1997 and 2007 (total of 3 million individuals) were used to identify all first hospital admissions for OSAS or either adenotonsillar or tonsillar hypertrophy. Next, individuals were categorized as either having or not having a parent affected by OSAS. Standardized incidence ratios (SIRs) with 95% confidence intervals (CIs) were estimated for boys and girls with a parent affected by OSAS. Children with OSAS or adenotonsillar or tonsillar hypertrophy without a parent affected by OSAS acted as the reference group (SIR = 1). Results: After accounting for socio-economic status, age, and geographic region, the SIRs of OSAS in boys and girls with a parent affected by OSAS were 3.09 (95% CI 1.83-4.90) and 4.46 (95% CI 2.68-6.98), respectively. The SIRs of adenotonsillar or tonsillar hypertrophy in boys and girls with a parent affected by OSAS were 1.82 (95% CI 1.54-2.14) and 1.56 (95% CI 1.30-1.87), respectively. Conclusion: This study indicates familial clustering of sleep-disordered breathing, which is important information for clinicians. (C) 2012 Elsevier B.V. All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Adenotonsillar hypertrophy, Children, Heredity, Hospitalization, Obstructive sleep apnoea, Population-based studies, Sleep-disordered, breathing
in
Sleep Medicine
volume
13
issue
6
pages
668 - 673
publisher
Elsevier
external identifiers
  • wos:000306304700019
  • scopus:84861925956
ISSN
1878-5506
DOI
10.1016/j.sleep.2012.01.014
language
English
LU publication?
yes
id
977ded8f-abe4-47fd-baeb-e6278d525acf (old id 3001258)
date added to LUP
2012-09-03 07:19:02
date last changed
2017-02-05 03:19:42
@article{977ded8f-abe4-47fd-baeb-e6278d525acf,
  abstract     = {Objective: To estimate the incidence of hospitalization for paediatric obstructive sleep apnoea syndrome (OSAS) or sleep-disordered breathing (SDB) caused by adenotonsillar or tonsillar hypertrophy without infection in children with a parent affected by OSAS. Patients and methods: Using the MigMed database at Lund University, hospital data on all children aged 0-18 years in Sweden between 1997 and 2007 (total of 3 million individuals) were used to identify all first hospital admissions for OSAS or either adenotonsillar or tonsillar hypertrophy. Next, individuals were categorized as either having or not having a parent affected by OSAS. Standardized incidence ratios (SIRs) with 95% confidence intervals (CIs) were estimated for boys and girls with a parent affected by OSAS. Children with OSAS or adenotonsillar or tonsillar hypertrophy without a parent affected by OSAS acted as the reference group (SIR = 1). Results: After accounting for socio-economic status, age, and geographic region, the SIRs of OSAS in boys and girls with a parent affected by OSAS were 3.09 (95% CI 1.83-4.90) and 4.46 (95% CI 2.68-6.98), respectively. The SIRs of adenotonsillar or tonsillar hypertrophy in boys and girls with a parent affected by OSAS were 1.82 (95% CI 1.54-2.14) and 1.56 (95% CI 1.30-1.87), respectively. Conclusion: This study indicates familial clustering of sleep-disordered breathing, which is important information for clinicians. (C) 2012 Elsevier B.V. All rights reserved.},
  author       = {Lundkvist, Karin and Sundquist, Kristina and Li, Xinjun and Friberg, Danielle},
  issn         = {1878-5506},
  keyword      = {Adenotonsillar hypertrophy,Children,Heredity,Hospitalization,Obstructive sleep apnoea,Population-based studies,Sleep-disordered,breathing},
  language     = {eng},
  number       = {6},
  pages        = {668--673},
  publisher    = {Elsevier},
  series       = {Sleep Medicine},
  title        = {Familial risk of sleep-disordered breathing},
  url          = {http://dx.doi.org/10.1016/j.sleep.2012.01.014},
  volume       = {13},
  year         = {2012},
}