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Pulse Pressure, Arterial Stiffness, and End-Organ Damage

Safar, Michel E.; Nilsson, Peter LU ; Blacher, Jacques and Mimran, Albert (2012) In Current Hypertension Reports 14(4). p.339-344
Abstract
Whereas larger arteries participate in the dampening of blood pressure (BP) oscillations resulting from intermittent ventricular ejection, smaller arteries steadily deliver an adequate supply of blood from the heart to the peripheral organs. Numerous active mechanisms are involved in this process. Cyclic stress acts differently from steady stress, inducing stronger and stiffer material of the vessel wall than under static conditions. Cyclic strain participates in the phenotypic plasticity of smooth muscle cells, initiates transduction mechanisms and induces the transcriptional profile of mechanically induced genes. Finally, the autoregulatory mechanism protecting the brain, heart and kidney from cardiovascular (CV) damage differ markedly... (More)
Whereas larger arteries participate in the dampening of blood pressure (BP) oscillations resulting from intermittent ventricular ejection, smaller arteries steadily deliver an adequate supply of blood from the heart to the peripheral organs. Numerous active mechanisms are involved in this process. Cyclic stress acts differently from steady stress, inducing stronger and stiffer material of the vessel wall than under static conditions. Cyclic strain participates in the phenotypic plasticity of smooth muscle cells, initiates transduction mechanisms and induces the transcriptional profile of mechanically induced genes. Finally, the autoregulatory mechanism protecting the brain, heart and kidney from cardiovascular (CV) damage differ markedly according to their localization. Whereas the heart is dependent on pulsatile forces, owing to the diastolic perfusion of coronary arteries, the brain and the kidney are rather influenced by steady mechanical forces. For the kidney, the transmission of pulsatile pressure may greatly contribute to glomerular sclerosis in the elderly. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Pulse pressure, Arterial stiffness, Vascular resistance, Wave, reflections, End-organ damage, Cardiovascular risk
in
Current Hypertension Reports
volume
14
issue
4
pages
339 - 344
publisher
Current Medicine Group LLC
external identifiers
  • wos:000305953200009
  • scopus:84865699003
ISSN
1534-3111
DOI
10.1007/s11906-012-0272-9
language
English
LU publication?
yes
id
cc641a4b-1c51-4464-8180-37819d6171b7 (old id 3001312)
date added to LUP
2012-09-03 07:19:41
date last changed
2017-08-20 03:22:56
@article{cc641a4b-1c51-4464-8180-37819d6171b7,
  abstract     = {Whereas larger arteries participate in the dampening of blood pressure (BP) oscillations resulting from intermittent ventricular ejection, smaller arteries steadily deliver an adequate supply of blood from the heart to the peripheral organs. Numerous active mechanisms are involved in this process. Cyclic stress acts differently from steady stress, inducing stronger and stiffer material of the vessel wall than under static conditions. Cyclic strain participates in the phenotypic plasticity of smooth muscle cells, initiates transduction mechanisms and induces the transcriptional profile of mechanically induced genes. Finally, the autoregulatory mechanism protecting the brain, heart and kidney from cardiovascular (CV) damage differ markedly according to their localization. Whereas the heart is dependent on pulsatile forces, owing to the diastolic perfusion of coronary arteries, the brain and the kidney are rather influenced by steady mechanical forces. For the kidney, the transmission of pulsatile pressure may greatly contribute to glomerular sclerosis in the elderly.},
  author       = {Safar, Michel E. and Nilsson, Peter and Blacher, Jacques and Mimran, Albert},
  issn         = {1534-3111},
  keyword      = {Pulse pressure,Arterial stiffness,Vascular resistance,Wave,reflections,End-organ damage,Cardiovascular risk},
  language     = {eng},
  number       = {4},
  pages        = {339--344},
  publisher    = {Current Medicine Group LLC},
  series       = {Current Hypertension Reports},
  title        = {Pulse Pressure, Arterial Stiffness, and End-Organ Damage},
  url          = {http://dx.doi.org/10.1007/s11906-012-0272-9},
  volume       = {14},
  year         = {2012},
}