Pulse Pressure, Arterial Stiffness, and End-Organ Damage
(2012) In Current Hypertension Reports 14(4). p.339-344- Abstract
- Whereas larger arteries participate in the dampening of blood pressure (BP) oscillations resulting from intermittent ventricular ejection, smaller arteries steadily deliver an adequate supply of blood from the heart to the peripheral organs. Numerous active mechanisms are involved in this process. Cyclic stress acts differently from steady stress, inducing stronger and stiffer material of the vessel wall than under static conditions. Cyclic strain participates in the phenotypic plasticity of smooth muscle cells, initiates transduction mechanisms and induces the transcriptional profile of mechanically induced genes. Finally, the autoregulatory mechanism protecting the brain, heart and kidney from cardiovascular (CV) damage differ markedly... (More)
- Whereas larger arteries participate in the dampening of blood pressure (BP) oscillations resulting from intermittent ventricular ejection, smaller arteries steadily deliver an adequate supply of blood from the heart to the peripheral organs. Numerous active mechanisms are involved in this process. Cyclic stress acts differently from steady stress, inducing stronger and stiffer material of the vessel wall than under static conditions. Cyclic strain participates in the phenotypic plasticity of smooth muscle cells, initiates transduction mechanisms and induces the transcriptional profile of mechanically induced genes. Finally, the autoregulatory mechanism protecting the brain, heart and kidney from cardiovascular (CV) damage differ markedly according to their localization. Whereas the heart is dependent on pulsatile forces, owing to the diastolic perfusion of coronary arteries, the brain and the kidney are rather influenced by steady mechanical forces. For the kidney, the transmission of pulsatile pressure may greatly contribute to glomerular sclerosis in the elderly. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3001312
- author
- Safar, Michel E. ; Nilsson, Peter LU ; Blacher, Jacques and Mimran, Albert
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Pulse pressure, Arterial stiffness, Vascular resistance, Wave, reflections, End-organ damage, Cardiovascular risk
- in
- Current Hypertension Reports
- volume
- 14
- issue
- 4
- pages
- 339 - 344
- publisher
- Current Medicine Group
- external identifiers
-
- wos:000305953200009
- scopus:84865699003
- pmid:22555981
- ISSN
- 1534-3111
- DOI
- 10.1007/s11906-012-0272-9
- language
- English
- LU publication?
- yes
- id
- cc641a4b-1c51-4464-8180-37819d6171b7 (old id 3001312)
- date added to LUP
- 2016-04-01 10:59:53
- date last changed
- 2022-04-20 08:16:49
@article{cc641a4b-1c51-4464-8180-37819d6171b7,
abstract = {{Whereas larger arteries participate in the dampening of blood pressure (BP) oscillations resulting from intermittent ventricular ejection, smaller arteries steadily deliver an adequate supply of blood from the heart to the peripheral organs. Numerous active mechanisms are involved in this process. Cyclic stress acts differently from steady stress, inducing stronger and stiffer material of the vessel wall than under static conditions. Cyclic strain participates in the phenotypic plasticity of smooth muscle cells, initiates transduction mechanisms and induces the transcriptional profile of mechanically induced genes. Finally, the autoregulatory mechanism protecting the brain, heart and kidney from cardiovascular (CV) damage differ markedly according to their localization. Whereas the heart is dependent on pulsatile forces, owing to the diastolic perfusion of coronary arteries, the brain and the kidney are rather influenced by steady mechanical forces. For the kidney, the transmission of pulsatile pressure may greatly contribute to glomerular sclerosis in the elderly.}},
author = {{Safar, Michel E. and Nilsson, Peter and Blacher, Jacques and Mimran, Albert}},
issn = {{1534-3111}},
keywords = {{Pulse pressure; Arterial stiffness; Vascular resistance; Wave; reflections; End-organ damage; Cardiovascular risk}},
language = {{eng}},
number = {{4}},
pages = {{339--344}},
publisher = {{Current Medicine Group}},
series = {{Current Hypertension Reports}},
title = {{Pulse Pressure, Arterial Stiffness, and End-Organ Damage}},
url = {{http://dx.doi.org/10.1007/s11906-012-0272-9}},
doi = {{10.1007/s11906-012-0272-9}},
volume = {{14}},
year = {{2012}},
}