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Monoclonal gammopathy of undetermined significance and risk of infections: a population-based study

Kristinsson, Sigurdur Y.; Tang, Min; Pfeiffer, Ruth M.; Bjorkholm, Magnus; Goldin, Lynn R.; Blimark, Cecilie; Mellqvist, Ulf-Henrik; Wahlin, Anders; Turesson, Ingemar LU and Landgren, Ola (2012) In Haematologica 97(6). p.854-858
Abstract
No comprehensive evaluation has been made to assess the risk of viral and bacterial infections among patients with monoclonal gammopathy of undetermined significance. Using population-based data from Sweden, we estimated risk of infections among 5,326 monoclonal gammopathy of undetermined significance patients compared to 20,161 matched controls. Patients with monoclonal gammopathy of undetermined significance had a 2-fold increased risk (P < 0.05) of developing any infection at 5- and 10-year follow up. More specifically, patients with monoclonal gammopathy of undetermined significance had an increased risk (P < 0.05) of bacterial (pneumonia, osteomyelitis, septicemia, pyelonephritis, cellulitis, endocarditis, and meningitis), and... (More)
No comprehensive evaluation has been made to assess the risk of viral and bacterial infections among patients with monoclonal gammopathy of undetermined significance. Using population-based data from Sweden, we estimated risk of infections among 5,326 monoclonal gammopathy of undetermined significance patients compared to 20,161 matched controls. Patients with monoclonal gammopathy of undetermined significance had a 2-fold increased risk (P < 0.05) of developing any infection at 5- and 10-year follow up. More specifically, patients with monoclonal gammopathy of undetermined significance had an increased risk (P < 0.05) of bacterial (pneumonia, osteomyelitis, septicemia, pyelonephritis, cellulitis, endocarditis, and meningitis), and viral (influenza and herpes zoster) infections. Patients with monoclonal gammopathy of undetermined significance with M-protein concentrations over 2.5 g/dL at diagnosis had highest risks of infections. However, the risk was also increased (P < 0.05) among those with concentrations below 0.5 g/dL. Patients with monoclonal gammopathy of undetermined significance who developed infections had no excess risk of developing multiple myeloma, Waldenstrom macroglobulinemia or related malignancy. Our findings provide novel insights into the mechanisms behind infections in patients with plasma cell dyscrasias, and may have clinical implications. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
monoclonal gammopathy of undetermined significance, infections, multiple, myeloma, bacteria, virus
in
Haematologica
volume
97
issue
6
pages
854 - 858
publisher
Ferrata Storti Foundation
external identifiers
  • wos:000306066500014
  • scopus:84862146052
ISSN
1592-8721
DOI
10.3324/haematol.2011.054015
language
English
LU publication?
yes
id
450cf23c-4daa-4d3b-b8a5-cdbb707bdf55 (old id 3001762)
date added to LUP
2012-09-03 07:20:52
date last changed
2017-11-19 03:54:43
@article{450cf23c-4daa-4d3b-b8a5-cdbb707bdf55,
  abstract     = {No comprehensive evaluation has been made to assess the risk of viral and bacterial infections among patients with monoclonal gammopathy of undetermined significance. Using population-based data from Sweden, we estimated risk of infections among 5,326 monoclonal gammopathy of undetermined significance patients compared to 20,161 matched controls. Patients with monoclonal gammopathy of undetermined significance had a 2-fold increased risk (P &lt; 0.05) of developing any infection at 5- and 10-year follow up. More specifically, patients with monoclonal gammopathy of undetermined significance had an increased risk (P &lt; 0.05) of bacterial (pneumonia, osteomyelitis, septicemia, pyelonephritis, cellulitis, endocarditis, and meningitis), and viral (influenza and herpes zoster) infections. Patients with monoclonal gammopathy of undetermined significance with M-protein concentrations over 2.5 g/dL at diagnosis had highest risks of infections. However, the risk was also increased (P &lt; 0.05) among those with concentrations below 0.5 g/dL. Patients with monoclonal gammopathy of undetermined significance who developed infections had no excess risk of developing multiple myeloma, Waldenstrom macroglobulinemia or related malignancy. Our findings provide novel insights into the mechanisms behind infections in patients with plasma cell dyscrasias, and may have clinical implications.},
  author       = {Kristinsson, Sigurdur Y. and Tang, Min and Pfeiffer, Ruth M. and Bjorkholm, Magnus and Goldin, Lynn R. and Blimark, Cecilie and Mellqvist, Ulf-Henrik and Wahlin, Anders and Turesson, Ingemar and Landgren, Ola},
  issn         = {1592-8721},
  keyword      = {monoclonal gammopathy of undetermined significance,infections,multiple,myeloma,bacteria,virus},
  language     = {eng},
  number       = {6},
  pages        = {854--858},
  publisher    = {Ferrata Storti Foundation},
  series       = {Haematologica},
  title        = {Monoclonal gammopathy of undetermined significance and risk of infections: a population-based study},
  url          = {http://dx.doi.org/10.3324/haematol.2011.054015},
  volume       = {97},
  year         = {2012},
}