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Risk factors for local recurrence after breast-conserving surgery

Fredriksson, I; Liljegren, G; Palm Sjövall, Margareta LU ; Arnesson, LG; Emdin, SO; Fornander, T; Lindgren, A; Nordgren, H; Idvall, I and Holmqvist, M, et al. (2003) In British Journal of Surgery 90(9). p.1093-1102
Abstract
Background: It is not clear whether risk factors for local recurrence after breast-conserving surgery differ in women having surgery for in situ or invasive cancer. Furthermore, the Nottingham Prognostic Index (NPI) and Nottingham Histological Grade (NHG) have been little studied as determinants of local recurrence risk. Method: In a case-control study (491 cases and 1098 controls) nested within a cohort of 7502 women who had surgery for in situ or invasive cancer of the breast, patient characteristics, tumour characteristics and treatment-related variables were evaluated as risk factors for local recurrence. Results: Multivariate conditional logistic regression analyses showed that age below 40 years, tumour multicentricity and an unclear... (More)
Background: It is not clear whether risk factors for local recurrence after breast-conserving surgery differ in women having surgery for in situ or invasive cancer. Furthermore, the Nottingham Prognostic Index (NPI) and Nottingham Histological Grade (NHG) have been little studied as determinants of local recurrence risk. Method: In a case-control study (491 cases and 1098 controls) nested within a cohort of 7502 women who had surgery for in situ or invasive cancer of the breast, patient characteristics, tumour characteristics and treatment-related variables were evaluated as risk factors for local recurrence. Results: Multivariate conditional logistic regression analyses showed that age below 40 years, tumour multicentricity and an unclear or unknown surgical margin were significant risk factors for local recurrence. Radiotherapy to the breast and adjuvant hormone therapy were protective. Cancer in situ was not associated with a higher risk of local recurrence than invasive cancer (odds ratio 1.0, 95 per cent confidence interval 0.8 to 1.3). NHG and NPI were not helpful in determining risk of local recurrence. Conclusion: Margin status, age, tumour multicentricity, and use of radiotherapy and adjuvant hormone therapy were important determinants of risk of local recurrence. With the exception of surgical margin, variables related to the quality of surgical management did not predict risk of local recurrence. (Less)
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Contribution to journal
publication status
published
subject
in
British Journal of Surgery
volume
90
issue
9
pages
1093 - 1102
publisher
John Wiley & Sons
external identifiers
  • pmid:12945077
  • wos:000185447500011
  • scopus:0141518226
ISSN
1365-2168
DOI
10.1002/bjs.4206
language
English
LU publication?
yes
id
86feedd8-03e9-492e-b8f2-09bb649e025a (old id 300641)
date added to LUP
2007-09-03 09:05:18
date last changed
2018-01-07 05:58:25
@article{86feedd8-03e9-492e-b8f2-09bb649e025a,
  abstract     = {Background: It is not clear whether risk factors for local recurrence after breast-conserving surgery differ in women having surgery for in situ or invasive cancer. Furthermore, the Nottingham Prognostic Index (NPI) and Nottingham Histological Grade (NHG) have been little studied as determinants of local recurrence risk. Method: In a case-control study (491 cases and 1098 controls) nested within a cohort of 7502 women who had surgery for in situ or invasive cancer of the breast, patient characteristics, tumour characteristics and treatment-related variables were evaluated as risk factors for local recurrence. Results: Multivariate conditional logistic regression analyses showed that age below 40 years, tumour multicentricity and an unclear or unknown surgical margin were significant risk factors for local recurrence. Radiotherapy to the breast and adjuvant hormone therapy were protective. Cancer in situ was not associated with a higher risk of local recurrence than invasive cancer (odds ratio 1.0, 95 per cent confidence interval 0.8 to 1.3). NHG and NPI were not helpful in determining risk of local recurrence. Conclusion: Margin status, age, tumour multicentricity, and use of radiotherapy and adjuvant hormone therapy were important determinants of risk of local recurrence. With the exception of surgical margin, variables related to the quality of surgical management did not predict risk of local recurrence.},
  author       = {Fredriksson, I and Liljegren, G and Palm Sjövall, Margareta and Arnesson, LG and Emdin, SO and Fornander, T and Lindgren, A and Nordgren, H and Idvall, I and Holmqvist, M and Holmberg, L and Frisell, J},
  issn         = {1365-2168},
  language     = {eng},
  number       = {9},
  pages        = {1093--1102},
  publisher    = {John Wiley & Sons},
  series       = {British Journal of Surgery},
  title        = {Risk factors for local recurrence after breast-conserving surgery},
  url          = {http://dx.doi.org/10.1002/bjs.4206},
  volume       = {90},
  year         = {2003},
}