Gene expression profile in multiple sclerosis patients and healthy controls: identifying pathways relevant to disease
(2003) In Human Molecular Genetics 12(17). p.2191-2199- Abstract
- Multiple sclerosis (MS) and other T cell-mediated autoimmune diseases develop in individuals carrying a complex susceptibility trait, probably following exposure to various environmental triggers. Owing to the presumed weak influence of single genes on disease predisposition and the recognized genetic heterogeneity of autoimmune disorders in humans, candidate gene searches in MS have been difficult. In an attempt to identify molecular markers indicative of disease status rather than susceptibility genes for MS, we show that gene expression profiling of peripheral blood mononuclear cells by cDNA microarrays can distinguish MS patients from healthy controls. Our findings support the concept that the activation of autoreactive T cells is of... (More)
- Multiple sclerosis (MS) and other T cell-mediated autoimmune diseases develop in individuals carrying a complex susceptibility trait, probably following exposure to various environmental triggers. Owing to the presumed weak influence of single genes on disease predisposition and the recognized genetic heterogeneity of autoimmune disorders in humans, candidate gene searches in MS have been difficult. In an attempt to identify molecular markers indicative of disease status rather than susceptibility genes for MS, we show that gene expression profiling of peripheral blood mononuclear cells by cDNA microarrays can distinguish MS patients from healthy controls. Our findings support the concept that the activation of autoreactive T cells is of primary importance for this complex organ-specific disorder and prompt further investigations on gene expression in peripheral blood cells aimed at characterizing disease phenotypes. (Less)
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https://lup.lub.lu.se/record/301306
- author
- organization
- publishing date
- 2003-09-14
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Human Molecular Genetics
- volume
- 12
- issue
- 17
- pages
- 2191 - 2199
- publisher
- Oxford University Press
- external identifiers
-
- wos:000185321300010
- pmid:12915464
- scopus:10744231299
- ISSN
- 0964-6906
- DOI
- 10.1093/hmg/ddg221
- language
- English
- LU publication?
- yes
- id
- b35a5845-3d75-44a1-8674-fc1c6429e419 (old id 301306)
- date added to LUP
- 2016-04-01 11:50:18
- date last changed
- 2024-04-08 14:20:36
@article{b35a5845-3d75-44a1-8674-fc1c6429e419, abstract = {{Multiple sclerosis (MS) and other T cell-mediated autoimmune diseases develop in individuals carrying a complex susceptibility trait, probably following exposure to various environmental triggers. Owing to the presumed weak influence of single genes on disease predisposition and the recognized genetic heterogeneity of autoimmune disorders in humans, candidate gene searches in MS have been difficult. In an attempt to identify molecular markers indicative of disease status rather than susceptibility genes for MS, we show that gene expression profiling of peripheral blood mononuclear cells by cDNA microarrays can distinguish MS patients from healthy controls. Our findings support the concept that the activation of autoreactive T cells is of primary importance for this complex organ-specific disorder and prompt further investigations on gene expression in peripheral blood cells aimed at characterizing disease phenotypes.}}, author = {{Bomprezzi, R and Ringnér, Markus and Kim, S and Bittner, ML and Khan, J and Chen, YD and Elkahloun, A and Yu, AM and Bielekova, B and Meltzer, PS and Martin, R and McFarland, HF and Trent, JM}}, issn = {{0964-6906}}, language = {{eng}}, month = {{09}}, number = {{17}}, pages = {{2191--2199}}, publisher = {{Oxford University Press}}, series = {{Human Molecular Genetics}}, title = {{Gene expression profile in multiple sclerosis patients and healthy controls: identifying pathways relevant to disease}}, url = {{http://dx.doi.org/10.1093/hmg/ddg221}}, doi = {{10.1093/hmg/ddg221}}, volume = {{12}}, year = {{2003}}, }