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Postmenopausal breast cancer risk in relation to sex steroid hormones, prolactin and SHBG (Sweden)

Manjer, Jonas LU ; Johansson, R; Berglund, Göran LU ; Janzon, Lars LU ; Kaaks, R; Agren, A and Lenner, P (2003) In Cancer Causes and Control 14(7). p.599-607
Abstract
Objective: High levels of sex steroid hormones and prolactin have been suggested to enhance breast cancer development. Low levels of SHBG may indicate high levels of (bio-available) steroid hormones. The present study investigates whether high levels of sex steroid hormones and prolactin, and/or low levels of SHBG, are associated with high breast cancer risk. Methods: Blood samples were collected in about 65,000 women participating in two population-based prospective cohort studies in Sweden. Follow-up yielded 173 postmenopausal breast cancer cases who had not been exposed to HRT. Levels of estrone, estradiol, SHBG, FSH, prolactin, testosterone, androstenedione and DHEAs were analysed in cases and 438 controls. Logistic regression analysis... (More)
Objective: High levels of sex steroid hormones and prolactin have been suggested to enhance breast cancer development. Low levels of SHBG may indicate high levels of (bio-available) steroid hormones. The present study investigates whether high levels of sex steroid hormones and prolactin, and/or low levels of SHBG, are associated with high breast cancer risk. Methods: Blood samples were collected in about 65,000 women participating in two population-based prospective cohort studies in Sweden. Follow-up yielded 173 postmenopausal breast cancer cases who had not been exposed to HRT. Levels of estrone, estradiol, SHBG, FSH, prolactin, testosterone, androstenedione and DHEAs were analysed in cases and 438 controls. Logistic regression analysis yielded odds ratios (ORs), with 95% confidence intervals, adjusted for potential confounders. Results: The risk of breast cancer was associated with the highest versus lowest quartiles of estrone, OR: 2.58 (1.50 - 4.44), estradiol (dichotomised: high versus low) (1.73: 1.04 - 2.88), and testosterone (1.87: 1.08 - 3.25). High risks, although not statistically significant, were seen for androstenedione (1.58: 0.92 - 2.72) and DHEAs ( 1.62: 0.89 - 2.72). No strong associations were seen between SHBG or prolactin and risk of breast cancer. Conclusions: High levels of estrone, estradiol, testosterone, and possibly androstenedione and DHEAs, in postmenopausal women are associated with a high risk of subsequent breast cancer. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
SHBG, sex steroid hormones, breast cancer, prolactin
in
Cancer Causes and Control
volume
14
issue
7
pages
599 - 607
publisher
Springer
external identifiers
  • wos:000185261300001
  • pmid:14575357
  • scopus:0141528677
ISSN
1573-7225
DOI
10.1023/A:1025671317220
language
English
LU publication?
yes
id
9ec5c6a2-840a-4fa4-90b3-b2066fb767ad (old id 301389)
date added to LUP
2007-09-17 19:39:28
date last changed
2017-07-23 03:41:59
@article{9ec5c6a2-840a-4fa4-90b3-b2066fb767ad,
  abstract     = {Objective: High levels of sex steroid hormones and prolactin have been suggested to enhance breast cancer development. Low levels of SHBG may indicate high levels of (bio-available) steroid hormones. The present study investigates whether high levels of sex steroid hormones and prolactin, and/or low levels of SHBG, are associated with high breast cancer risk. Methods: Blood samples were collected in about 65,000 women participating in two population-based prospective cohort studies in Sweden. Follow-up yielded 173 postmenopausal breast cancer cases who had not been exposed to HRT. Levels of estrone, estradiol, SHBG, FSH, prolactin, testosterone, androstenedione and DHEAs were analysed in cases and 438 controls. Logistic regression analysis yielded odds ratios (ORs), with 95% confidence intervals, adjusted for potential confounders. Results: The risk of breast cancer was associated with the highest versus lowest quartiles of estrone, OR: 2.58 (1.50 - 4.44), estradiol (dichotomised: high versus low) (1.73: 1.04 - 2.88), and testosterone (1.87: 1.08 - 3.25). High risks, although not statistically significant, were seen for androstenedione (1.58: 0.92 - 2.72) and DHEAs ( 1.62: 0.89 - 2.72). No strong associations were seen between SHBG or prolactin and risk of breast cancer. Conclusions: High levels of estrone, estradiol, testosterone, and possibly androstenedione and DHEAs, in postmenopausal women are associated with a high risk of subsequent breast cancer.},
  author       = {Manjer, Jonas and Johansson, R and Berglund, Göran and Janzon, Lars and Kaaks, R and Agren, A and Lenner, P},
  issn         = {1573-7225},
  keyword      = {SHBG,sex steroid hormones,breast cancer,prolactin},
  language     = {eng},
  number       = {7},
  pages        = {599--607},
  publisher    = {Springer},
  series       = {Cancer Causes and Control},
  title        = {Postmenopausal breast cancer risk in relation to sex steroid hormones, prolactin and SHBG (Sweden)},
  url          = {http://dx.doi.org/10.1023/A:1025671317220},
  volume       = {14},
  year         = {2003},
}