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Coxsackie virus B antibodies are increased in HLA DR3-MICA5.1 positive type 1 diabetes patients in the Linkoping region of Sweden

Gupta, M; Nikitina-Zake, L; Landin-Olsson, Mona LU ; Kockum, I and Sanjeevi, CB (2003) In Human Immunology 64(9). p.874-879
Abstract
Type 1 diabetes mellitus (T1DM) is an autoimmune disorder in which genetics and environmental factors play a role. Among the environmental factors, viruses (especially Coxsackie virus B [CBV]), and among genetic markers, human leukocyte antigen (HLA) DRB1*04-DQA1*0301-DQB1*0302 (DR4-DQ8) and DRB1*03-DQA1*0501-DQB1*0201 (DR3-DQ2), and major histocompatibility complex class I chain-related gene-A (MICA) alleles 5 and 5.1 have been reported to be associated with T1DM in Caucasians. Sweden ranks third in the world for T1DM incidence. In Sweden, the Linkoping region indicates the highest incidence for T1DM. In this study, we analyzed whether antibodies against CBV are increased in DR3, DR4, MICA5, or MICA5.1 positive patients from Linkoping (n... (More)
Type 1 diabetes mellitus (T1DM) is an autoimmune disorder in which genetics and environmental factors play a role. Among the environmental factors, viruses (especially Coxsackie virus B [CBV]), and among genetic markers, human leukocyte antigen (HLA) DRB1*04-DQA1*0301-DQB1*0302 (DR4-DQ8) and DRB1*03-DQA1*0501-DQB1*0201 (DR3-DQ2), and major histocompatibility complex class I chain-related gene-A (MICA) alleles 5 and 5.1 have been reported to be associated with T1DM in Caucasians. Sweden ranks third in the world for T1DM incidence. In Sweden, the Linkoping region indicates the highest incidence for T1DM. In this study, we analyzed whether antibodies against CBV are increased in DR3, DR4, MICA5, or MICA5.1 positive patients from Linkoping (n = 46) and from Swedish population as a whole (n = 298) between the age of 0 and 15 years old. There was no difference in the frequency of antibodies to CBV in patients compared with controls in Linkoping (26% vs 23%) or in all of Sweden (26% vs 21%). However, CBV antibodies were increased in DR3, DR3-DR4 (heterozygous), DR3-MICA5.1, and DR3-DR4-MICA5.1 positive compared with DR3, DR3-DR4, DR3-MICA5.1, and DR3-DR4-MICA5.1 negative patients in Linkoping (p < 0.05 for all), but not in Swedish population as a whole. Thus, our study suggests that in addition to DR3, MICA5.1 has an influence on the immune response to CBV infection in patients from Linkoping. (C) American Society for Histocompatibility and Immunogenetics, 2003. Published by Elsevier Inc. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
CBV, MICA, HLA-DR, HLA-DQ, type 1 diabetes
in
Human Immunology
volume
64
issue
9
pages
874 - 879
publisher
Elsevier
external identifiers
  • pmid:12941542
  • wos:000185197900006
  • scopus:0041833338
ISSN
0198-8859
DOI
10.1016/S0198-8859(03)00149-6
language
English
LU publication?
yes
id
f447ef60-adfb-4c62-99c6-c5c8103608ae (old id 301739)
date added to LUP
2007-09-03 12:24:18
date last changed
2018-05-29 11:27:24
@article{f447ef60-adfb-4c62-99c6-c5c8103608ae,
  abstract     = {Type 1 diabetes mellitus (T1DM) is an autoimmune disorder in which genetics and environmental factors play a role. Among the environmental factors, viruses (especially Coxsackie virus B [CBV]), and among genetic markers, human leukocyte antigen (HLA) DRB1*04-DQA1*0301-DQB1*0302 (DR4-DQ8) and DRB1*03-DQA1*0501-DQB1*0201 (DR3-DQ2), and major histocompatibility complex class I chain-related gene-A (MICA) alleles 5 and 5.1 have been reported to be associated with T1DM in Caucasians. Sweden ranks third in the world for T1DM incidence. In Sweden, the Linkoping region indicates the highest incidence for T1DM. In this study, we analyzed whether antibodies against CBV are increased in DR3, DR4, MICA5, or MICA5.1 positive patients from Linkoping (n = 46) and from Swedish population as a whole (n = 298) between the age of 0 and 15 years old. There was no difference in the frequency of antibodies to CBV in patients compared with controls in Linkoping (26% vs 23%) or in all of Sweden (26% vs 21%). However, CBV antibodies were increased in DR3, DR3-DR4 (heterozygous), DR3-MICA5.1, and DR3-DR4-MICA5.1 positive compared with DR3, DR3-DR4, DR3-MICA5.1, and DR3-DR4-MICA5.1 negative patients in Linkoping (p &lt; 0.05 for all), but not in Swedish population as a whole. Thus, our study suggests that in addition to DR3, MICA5.1 has an influence on the immune response to CBV infection in patients from Linkoping. (C) American Society for Histocompatibility and Immunogenetics, 2003. Published by Elsevier Inc.},
  author       = {Gupta, M and Nikitina-Zake, L and Landin-Olsson, Mona and Kockum, I and Sanjeevi, CB},
  issn         = {0198-8859},
  keyword      = {CBV,MICA,HLA-DR,HLA-DQ,type 1 diabetes},
  language     = {eng},
  number       = {9},
  pages        = {874--879},
  publisher    = {Elsevier},
  series       = {Human Immunology},
  title        = {Coxsackie virus B antibodies are increased in HLA DR3-MICA5.1 positive type 1 diabetes patients in the Linkoping region of Sweden},
  url          = {http://dx.doi.org/10.1016/S0198-8859(03)00149-6},
  volume       = {64},
  year         = {2003},
}