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Cerebellar Modules and Their Role as Operational Cerebellar Processing Units

Apps, Richard; Hawkes, Richard; Aoki, Sho; Bengtsson, Fredrik LU ; Brown, Amanda M.; Chen, Gang; Ebner, Timothy J.; Isope, Philippe; Jörntell, Henrik LU and Lackey, Elizabeth P., et al. (2018) In Cerebellum 17(5). p.654-682
Abstract

The compartmentalization of the cerebellum into modules is often used to discuss its function. What, exactly, can be considered a module, how do they operate, can they be subdivided and do they act individually or in concert are only some of the key questions discussed in this consensus paper. Experts studying cerebellar compartmentalization give their insights on the structure and function of cerebellar modules, with the aim of providing an up-to-date review of the extensive literature on this subject. Starting with an historical perspective indicating that the basis of the modular organization is formed by matching olivocorticonuclear connectivity, this is followed by consideration of anatomical and chemical modular boundaries,... (More)

The compartmentalization of the cerebellum into modules is often used to discuss its function. What, exactly, can be considered a module, how do they operate, can they be subdivided and do they act individually or in concert are only some of the key questions discussed in this consensus paper. Experts studying cerebellar compartmentalization give their insights on the structure and function of cerebellar modules, with the aim of providing an up-to-date review of the extensive literature on this subject. Starting with an historical perspective indicating that the basis of the modular organization is formed by matching olivocorticonuclear connectivity, this is followed by consideration of anatomical and chemical modular boundaries, revealing a relation between anatomical, chemical, and physiological borders. In addition, the question is asked what the smallest operational unit of the cerebellum might be. Furthermore, it has become clear that chemical diversity of Purkinje cells also results in diversity of information processing between cerebellar modules. An additional important consideration is the relation between modular compartmentalization and the organization of the mossy fiber system, resulting in the concept of modular plasticity. Finally, examination of cerebellar output patterns suggesting cooperation between modules and recent work on modular aspects of emotional behavior are discussed. Despite the general consensus that the cerebellum has a modular organization, many questions remain. The authors hope that this joint review will inspire future cerebellar research so that we are better able to understand how this brain structure makes its vital contribution to behavior in its most general form.

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published
subject
keywords
Aldolase C, Cerebellum, Climbing fibers, Compartments, Functional organization, Longitudinal stripes, Microzones, Mossy fibers, Purkinje cells, Zebrin
in
Cerebellum
volume
17
issue
5
pages
654 - 682
publisher
Informa Healthcare
external identifiers
  • scopus:85048050764
ISSN
1473-4222
DOI
10.1007/s12311-018-0952-3
language
English
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yes
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3018f1d4-ce8b-4a21-b7ed-9536bd753a56
date added to LUP
2018-06-19 12:07:45
date last changed
2019-09-17 04:34:25
@article{3018f1d4-ce8b-4a21-b7ed-9536bd753a56,
  abstract     = {<p>The compartmentalization of the cerebellum into modules is often used to discuss its function. What, exactly, can be considered a module, how do they operate, can they be subdivided and do they act individually or in concert are only some of the key questions discussed in this consensus paper. Experts studying cerebellar compartmentalization give their insights on the structure and function of cerebellar modules, with the aim of providing an up-to-date review of the extensive literature on this subject. Starting with an historical perspective indicating that the basis of the modular organization is formed by matching olivocorticonuclear connectivity, this is followed by consideration of anatomical and chemical modular boundaries, revealing a relation between anatomical, chemical, and physiological borders. In addition, the question is asked what the smallest operational unit of the cerebellum might be. Furthermore, it has become clear that chemical diversity of Purkinje cells also results in diversity of information processing between cerebellar modules. An additional important consideration is the relation between modular compartmentalization and the organization of the mossy fiber system, resulting in the concept of modular plasticity. Finally, examination of cerebellar output patterns suggesting cooperation between modules and recent work on modular aspects of emotional behavior are discussed. Despite the general consensus that the cerebellum has a modular organization, many questions remain. The authors hope that this joint review will inspire future cerebellar research so that we are better able to understand how this brain structure makes its vital contribution to behavior in its most general form.</p>},
  author       = {Apps, Richard and Hawkes, Richard and Aoki, Sho and Bengtsson, Fredrik and Brown, Amanda M. and Chen, Gang and Ebner, Timothy J. and Isope, Philippe and Jörntell, Henrik and Lackey, Elizabeth P. and Lawrenson, Charlotte and Lumb, Bridget and Schonewille, Martijn and Sillitoe, Roy V. and Spaeth, Ludovic and Sugihara, Izumi and Valera, Antoine and Voogd, Jan and Wylie, Douglas R. and Ruigrok, Tom J.H.},
  issn         = {1473-4222},
  keyword      = {Aldolase C,Cerebellum,Climbing fibers,Compartments,Functional organization,Longitudinal stripes,Microzones,Mossy fibers,Purkinje cells,Zebrin},
  language     = {eng},
  month        = {06},
  number       = {5},
  pages        = {654--682},
  publisher    = {Informa Healthcare},
  series       = {Cerebellum},
  title        = {Cerebellar Modules and Their Role as Operational Cerebellar Processing Units},
  url          = {http://dx.doi.org/10.1007/s12311-018-0952-3},
  volume       = {17},
  year         = {2018},
}