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Interaction between smoking, GSTM1 deletion and colorectal cancer: results from the GSEC study

Smits, KM; Gaspari, L; Weijenberg, MP; Dolzan, V; Golka, K; Roemer, HC; Kristensen, VN; Lechner, MC; Mehling, GI and Seidegård, Janeric LU , et al. (2003) In Biomarkers 8(3-4). p.299-310
Abstract
Cigarette smoking has inconsistently been associated with an increased risk of colorectal cancer. One of the enzymes responsible for the detoxification of the carcinogenic compounds present in tobacco smoke is glutathione S-transferase-mu (GST-mu). The gene that codes for this enzyme is GSTM1. In this study, we evaluated the associations and interaction between GSTM1 deletion, smoking behaviour and the development of colorectal cancer. We performed a pooled analysis within the International Collaborative Study on Genetic Susceptibility to Environmental Carcinogens (GSEC). We selected six studies on colorectal cancer, including 1130 cases and 2519 controls, and restricted our analyses to Caucasians because the number of patients from other... (More)
Cigarette smoking has inconsistently been associated with an increased risk of colorectal cancer. One of the enzymes responsible for the detoxification of the carcinogenic compounds present in tobacco smoke is glutathione S-transferase-mu (GST-mu). The gene that codes for this enzyme is GSTM1. In this study, we evaluated the associations and interaction between GSTM1 deletion, smoking behaviour and the development of colorectal cancer. We performed a pooled analysis within the International Collaborative Study on Genetic Susceptibility to Environmental Carcinogens (GSEC). We selected six studies on colorectal cancer, including 1130 cases and 2519 controls, and restricted our analyses to Caucasians because the number of patients from other races was too limited. In addition we performed a meta-analysis including the studies from the GSEC database and other studies identified on MEDLINE on the same subject. The prevalence of the GSTM1 null genotype was within the range reported in other studies: 51.8% of the cases had the GSTM1 null genotype versus 56.6% of the controls. No significant association between the GSTM1 null genotype and colorectal cancer was found (odds ratio 0.92, 95% confidence interval 0.73-1.14). Our results suggest a possible positive association between lack of the GST-mu enzyme and colorectal cancer for non-smoking women (odds ratio 1.47, 95% confidence interval 0.80-2.70). There was no interaction between the effects of smoking and GSTM1 genotype on colorectal cancer risk in men and women (chi(2) = 0.007, p = 0.97). Our findings do not support an association between the GSTM1 null genotype and colorectal cancer. In addition, we did not find any modification of the smoking-induced colorectal cancer risk by GSTM1 genotype. (Less)
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publication status
published
subject
keywords
metabolic gene polymorphism, molecular epidemiology, pooled analysis
in
Biomarkers
volume
8
issue
3-4
pages
299 - 310
publisher
Taylor & Francis
external identifiers
  • wos:000184952000009
  • scopus:12444286848
ISSN
1366-5804
DOI
10.1080/1354750031000121467
language
English
LU publication?
yes
id
dab081e1-d519-4a64-a1b4-3fde5aa45b6e (old id 303647)
date added to LUP
2007-09-22 11:09:10
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2017-07-23 03:44:51
@article{dab081e1-d519-4a64-a1b4-3fde5aa45b6e,
  abstract     = {Cigarette smoking has inconsistently been associated with an increased risk of colorectal cancer. One of the enzymes responsible for the detoxification of the carcinogenic compounds present in tobacco smoke is glutathione S-transferase-mu (GST-mu). The gene that codes for this enzyme is GSTM1. In this study, we evaluated the associations and interaction between GSTM1 deletion, smoking behaviour and the development of colorectal cancer. We performed a pooled analysis within the International Collaborative Study on Genetic Susceptibility to Environmental Carcinogens (GSEC). We selected six studies on colorectal cancer, including 1130 cases and 2519 controls, and restricted our analyses to Caucasians because the number of patients from other races was too limited. In addition we performed a meta-analysis including the studies from the GSEC database and other studies identified on MEDLINE on the same subject. The prevalence of the GSTM1 null genotype was within the range reported in other studies: 51.8% of the cases had the GSTM1 null genotype versus 56.6% of the controls. No significant association between the GSTM1 null genotype and colorectal cancer was found (odds ratio 0.92, 95% confidence interval 0.73-1.14). Our results suggest a possible positive association between lack of the GST-mu enzyme and colorectal cancer for non-smoking women (odds ratio 1.47, 95% confidence interval 0.80-2.70). There was no interaction between the effects of smoking and GSTM1 genotype on colorectal cancer risk in men and women (chi(2) = 0.007, p = 0.97). Our findings do not support an association between the GSTM1 null genotype and colorectal cancer. In addition, we did not find any modification of the smoking-induced colorectal cancer risk by GSTM1 genotype.},
  author       = {Smits, KM and Gaspari, L and Weijenberg, MP and Dolzan, V and Golka, K and Roemer, HC and Kristensen, VN and Lechner, MC and Mehling, GI and Seidegård, Janeric and Strange, RC and Taioli, E},
  issn         = {1366-5804},
  keyword      = {metabolic gene polymorphism,molecular epidemiology,pooled analysis},
  language     = {eng},
  number       = {3-4},
  pages        = {299--310},
  publisher    = {Taylor & Francis},
  series       = {Biomarkers},
  title        = {Interaction between smoking, GSTM1 deletion and colorectal cancer: results from the GSEC study},
  url          = {http://dx.doi.org/10.1080/1354750031000121467},
  volume       = {8},
  year         = {2003},
}