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Addressing harms of screening – A review of outcomes in Cochrane reviews and suggestions for next steps

Johansson, Minna LU ; Borys, Franciszek ; Peterson, Hanna ; Bilamour, Giulia ; Bruschettini, Matteo LU orcid and Jørgensen, Karsten Juhl (2021) In Journal of Clinical Epidemiology 129. p.68-73
Abstract

Objective: To investigate if Cochrane reviews that assess screening interventions address their major harms. Study design and setting: A systematic search for Cochrane reviews that assess screening interventions was performed. Two authors independently screened abstracts, assessed full-texts, and extracted data from included reviews. For each review, two authors judged whether each predefined harm was relevant. When the harm was judged as of questionable relevance, the review was excluded from the denominator in our calculations. Results: Forty-seven reviews were included. Overdiagnosis was addressed in 6 of 39 (15%), overtreatment in 7 of 43 (16%), and psychosocial consequences in 30 of 47 (64%) of reviews where this was judged... (More)

Objective: To investigate if Cochrane reviews that assess screening interventions address their major harms. Study design and setting: A systematic search for Cochrane reviews that assess screening interventions was performed. Two authors independently screened abstracts, assessed full-texts, and extracted data from included reviews. For each review, two authors judged whether each predefined harm was relevant. When the harm was judged as of questionable relevance, the review was excluded from the denominator in our calculations. Results: Forty-seven reviews were included. Overdiagnosis was addressed in 6 of 39 (15%), overtreatment in 7 of 43 (16%), and psychosocial consequences in 30 of 47 (64%) of reviews where this was judged relevant. When data on harms were included, they were generally not treated with the same methodological rigor as the benefits, with no assessment of the risk of bias or certainty of the evidence. About half of the Abstracts, Plain Language Summaries, and Summary of Findings tables did not include any harms. Conclusion: The underreporting of harms of screening in Cochrane reviews likely reflects primary research and is problematic. We call for broad collaboration to develop reporting guidelines and core outcome sets for studies of screening interventions.

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author
; ; ; ; and
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Harm, Overdiagnosis, Overtreatment, Research reporting, Screening
in
Journal of Clinical Epidemiology
volume
129
pages
6 pages
publisher
Elsevier
external identifiers
  • pmid:33010402
  • scopus:85094621364
ISSN
0895-4356
DOI
10.1016/j.jclinepi.2020.09.030
language
English
LU publication?
no
id
303f9a7d-ecd9-4720-ba41-62414df558ad
date added to LUP
2020-11-13 07:29:24
date last changed
2024-06-27 01:19:03
@article{303f9a7d-ecd9-4720-ba41-62414df558ad,
  abstract     = {{<p>Objective: To investigate if Cochrane reviews that assess screening interventions address their major harms. Study design and setting: A systematic search for Cochrane reviews that assess screening interventions was performed. Two authors independently screened abstracts, assessed full-texts, and extracted data from included reviews. For each review, two authors judged whether each predefined harm was relevant. When the harm was judged as of questionable relevance, the review was excluded from the denominator in our calculations. Results: Forty-seven reviews were included. Overdiagnosis was addressed in 6 of 39 (15%), overtreatment in 7 of 43 (16%), and psychosocial consequences in 30 of 47 (64%) of reviews where this was judged relevant. When data on harms were included, they were generally not treated with the same methodological rigor as the benefits, with no assessment of the risk of bias or certainty of the evidence. About half of the Abstracts, Plain Language Summaries, and Summary of Findings tables did not include any harms. Conclusion: The underreporting of harms of screening in Cochrane reviews likely reflects primary research and is problematic. We call for broad collaboration to develop reporting guidelines and core outcome sets for studies of screening interventions.</p>}},
  author       = {{Johansson, Minna and Borys, Franciszek and Peterson, Hanna and Bilamour, Giulia and Bruschettini, Matteo and Jørgensen, Karsten Juhl}},
  issn         = {{0895-4356}},
  keywords     = {{Harm; Overdiagnosis; Overtreatment; Research reporting; Screening}},
  language     = {{eng}},
  pages        = {{68--73}},
  publisher    = {{Elsevier}},
  series       = {{Journal of Clinical Epidemiology}},
  title        = {{Addressing harms of screening – A review of outcomes in Cochrane reviews and suggestions for next steps}},
  url          = {{http://dx.doi.org/10.1016/j.jclinepi.2020.09.030}},
  doi          = {{10.1016/j.jclinepi.2020.09.030}},
  volume       = {{129}},
  year         = {{2021}},
}