A Biophysical Model of Electrical Activity in Human β-Cells.
(2010) In Biophysical Journal 99(10). p.3200-3207- Abstract
- Electrical activity in pancreatic β-cells plays a pivotal role in glucose-stimulated insulin secretion by coupling metabolism to calcium-triggered exocytosis. Mathematical models based on rodent data have helped in understanding the mechanisms underlying the electrophysiological patterns observed in laboratory animals. However, human β-cells differ in several aspects, and in particular in their electrophysiological characteristics, from rodent β-cells. Hence, from a clinical perspective and to obtain insight into the defects in insulin secretion relevant for diabetes mellitus, it is important to study human β-cells. This work presents the first mathematical model of electrical activity based entirely on published ion channel... (More)
- Electrical activity in pancreatic β-cells plays a pivotal role in glucose-stimulated insulin secretion by coupling metabolism to calcium-triggered exocytosis. Mathematical models based on rodent data have helped in understanding the mechanisms underlying the electrophysiological patterns observed in laboratory animals. However, human β-cells differ in several aspects, and in particular in their electrophysiological characteristics, from rodent β-cells. Hence, from a clinical perspective and to obtain insight into the defects in insulin secretion relevant for diabetes mellitus, it is important to study human β-cells. This work presents the first mathematical model of electrical activity based entirely on published ion channel characteristics of human β-cells. The model reproduces satisfactorily a series of experimentally observed patterns in human β-cells, such as spiking and rapid bursting electrical activity, and their response to a range of ion channel antagonists. The possibility of Human Ether-a-Go-Go-related- and leak channels as drug targets for diabetes treatment is discussed based on model results. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1731929
- author
- Pedersen, Morten Gram LU
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Biophysical Journal
- volume
- 99
- issue
- 10
- pages
- 3200 - 3207
- publisher
- Cell Press
- external identifiers
-
- wos:000284438700013
- pmid:21081067
- scopus:78549279833
- pmid:21081067
- ISSN
- 1542-0086
- DOI
- 10.1016/j.bpj.2010.09.004
- language
- English
- LU publication?
- yes
- id
- 3042c162-f8db-45ae-a6e4-b3522114e31a (old id 1731929)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/21081067?dopt=Abstract
- date added to LUP
- 2016-04-01 10:15:05
- date last changed
- 2022-01-25 21:22:30
@article{3042c162-f8db-45ae-a6e4-b3522114e31a,
abstract = {{Electrical activity in pancreatic β-cells plays a pivotal role in glucose-stimulated insulin secretion by coupling metabolism to calcium-triggered exocytosis. Mathematical models based on rodent data have helped in understanding the mechanisms underlying the electrophysiological patterns observed in laboratory animals. However, human β-cells differ in several aspects, and in particular in their electrophysiological characteristics, from rodent β-cells. Hence, from a clinical perspective and to obtain insight into the defects in insulin secretion relevant for diabetes mellitus, it is important to study human β-cells. This work presents the first mathematical model of electrical activity based entirely on published ion channel characteristics of human β-cells. The model reproduces satisfactorily a series of experimentally observed patterns in human β-cells, such as spiking and rapid bursting electrical activity, and their response to a range of ion channel antagonists. The possibility of Human Ether-a-Go-Go-related- and leak channels as drug targets for diabetes treatment is discussed based on model results.}},
author = {{Pedersen, Morten Gram}},
issn = {{1542-0086}},
language = {{eng}},
number = {{10}},
pages = {{3200--3207}},
publisher = {{Cell Press}},
series = {{Biophysical Journal}},
title = {{A Biophysical Model of Electrical Activity in Human β-Cells.}},
url = {{https://lup.lub.lu.se/search/files/1689294/1748013.pdf}},
doi = {{10.1016/j.bpj.2010.09.004}},
volume = {{99}},
year = {{2010}},
}