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Follow-up of patients with Hodgkin's disease following curative treatment: the routine CT scan is of little value

Dryver, ET; Jernström, Helena LU ; Tompkins, K; Buckstein, R and Imrie, KR (2003) In British Journal of Cancer 89(3). p.482-486
Abstract
A total of 10-40% of patients with Hodgkin's disease relapse following initial curative therapy. Intensive follow-up is resource intensive and may identify false relapses. We performed a retrospective review of all patients with Hodgkin's disease treated at our centre between 1990 and 1999 to evaluate the utility of the components of follow-up. A total of 107 patients met the inclusion and exclusion criteria. The median age was 33 years and the median duration of follow-up 38 months. The total number of follow-up visits was 1209 and total number of CT scans 283. There were 109 suspected relapses of which 22 proved to be true relapses. Of the latter, 14 were identified clinically, six radiologically and two via lab testing. The routine CT... (More)
A total of 10-40% of patients with Hodgkin's disease relapse following initial curative therapy. Intensive follow-up is resource intensive and may identify false relapses. We performed a retrospective review of all patients with Hodgkin's disease treated at our centre between 1990 and 1999 to evaluate the utility of the components of follow-up. A total of 107 patients met the inclusion and exclusion criteria. The median age was 33 years and the median duration of follow-up 38 months. The total number of follow-up visits was 1209 and total number of CT scans 283. There were 109 suspected relapses of which 22 proved to be true relapses. Of the latter, 14 were identified clinically, six radiologically and two via lab testing. The routine CT scan detected only two relapses (9%), yet accounted for 29% of the total follow-up costs. Based on data from our centre, the cost per true relapse was $6000 US, 49% incurred by radiological tests. The majority of the cost of follow-up was incurred by routine follow-up (84%) as opposed to the investigation of suspected relapses (16%). We conclude that most true relapses are clinically symptomatic and that the routine CT is an expensive and inefficient mode of routine follow-up. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
relapse, Hodgkin's disease, follow-up, computed tomography scan
in
British Journal of Cancer
volume
89
issue
3
pages
482 - 486
publisher
Nature Publishing Group
external identifiers
  • pmid:12888816
  • wos:000184553100011
  • scopus:0042978494
ISSN
1532-1827
DOI
10.1038/sj.bjc.6601052
language
English
LU publication?
yes
id
91dd6813-2f36-4bb2-b3e6-0cbb87307a86 (old id 304694)
date added to LUP
2007-08-29 12:57:15
date last changed
2018-10-03 10:03:42
@article{91dd6813-2f36-4bb2-b3e6-0cbb87307a86,
  abstract     = {A total of 10-40% of patients with Hodgkin's disease relapse following initial curative therapy. Intensive follow-up is resource intensive and may identify false relapses. We performed a retrospective review of all patients with Hodgkin's disease treated at our centre between 1990 and 1999 to evaluate the utility of the components of follow-up. A total of 107 patients met the inclusion and exclusion criteria. The median age was 33 years and the median duration of follow-up 38 months. The total number of follow-up visits was 1209 and total number of CT scans 283. There were 109 suspected relapses of which 22 proved to be true relapses. Of the latter, 14 were identified clinically, six radiologically and two via lab testing. The routine CT scan detected only two relapses (9%), yet accounted for 29% of the total follow-up costs. Based on data from our centre, the cost per true relapse was $6000 US, 49% incurred by radiological tests. The majority of the cost of follow-up was incurred by routine follow-up (84%) as opposed to the investigation of suspected relapses (16%). We conclude that most true relapses are clinically symptomatic and that the routine CT is an expensive and inefficient mode of routine follow-up.},
  author       = {Dryver, ET and Jernström, Helena and Tompkins, K and Buckstein, R and Imrie, KR},
  issn         = {1532-1827},
  keyword      = {relapse,Hodgkin's disease,follow-up,computed tomography scan},
  language     = {eng},
  number       = {3},
  pages        = {482--486},
  publisher    = {Nature Publishing Group},
  series       = {British Journal of Cancer},
  title        = {Follow-up of patients with Hodgkin's disease following curative treatment: the routine CT scan is of little value},
  url          = {http://dx.doi.org/10.1038/sj.bjc.6601052},
  volume       = {89},
  year         = {2003},
}