Low Postnatal Serum IGF-I levels is Associated with Bronchopulmonary Dysplasia (BPD).
Löfqvist, Chatarina ; Hellgren, Gunnel ; Niklasson, Aimon ; Engström, Eva ; Ley, David LU and Pupp, Ingrid LU
(2012)
In Acta paediatrica
101(12).
p.1211-1216
- Abstract
- Aim:
To characterize postnatal changes in serum IGF-I in relation to development of bronchopulmonary dysplasia (BPD) in very preterm infants.
Methods:
Longitudinal study of 108 infants with mean (SD) gestational age 27.2 (2.2) weeks. Weekly serum samples of IGF-I were analyzed from birth until postmenstrual age 36 weeks. Multivariate models were developed to identify independent predictors of BPD.
Results:
Postnatal mean IGF-I levels at postnatal day 3 to 21 were lower in infants with BPD compared to infants with no BPD (16 vs. 26 ug/L, p<0.001). Longitudinal postnatal change in IGF-I levels (IGF-I regression coefficient (β), postnatal days 3 to 21, was lower in... (More) - Aim:
To characterize postnatal changes in serum IGF-I in relation to development of bronchopulmonary dysplasia (BPD) in very preterm infants.
Methods:
Longitudinal study of 108 infants with mean (SD) gestational age 27.2 (2.2) weeks. Weekly serum samples of IGF-I were analyzed from birth until postmenstrual age 36 weeks. Multivariate models were developed to identify independent predictors of BPD.
Results:
Postnatal mean IGF-I levels at postnatal day 3 to 21 were lower in infants with BPD compared to infants with no BPD (16 vs. 26 ug/L, p<0.001). Longitudinal postnatal change in IGF-I levels (IGF-I regression coefficient (β), postnatal days 3 to 21, was lower in infants with BPD compared to infants with no BPD (0.28 vs. 0.97, p=0.002) and mean IGF-I during postmenstrual age 30-33 weeks was lower in infants with BPD as compared to infants without BPD (22 vs. 29 ug/L, p<0.001). In a binomial multiple regression model lower gestational age, male gender and lower mean serum IGF-I levels during postnatal day 3-21 were the most predictive risk factors associated with BPD (r(2) =0.634, p<0.001).
Conclusion:
Lower IGF-I concentrations during the first weeks after very preterm birth are associated with later development of BPD. © 2012 The Author(s)/Acta Paediatrica © 2012 Foundation Acta Paediatrica. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3047137
- author
- Löfqvist, Chatarina
; Hellgren, Gunnel
; Niklasson, Aimon
; Engström, Eva
; Ley, David
LU
and Pupp, Ingrid
LU
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Bronchopulmonary dysplasia, Premature, infants, Insulin-like growth factor-1
- in
- Acta paediatrica
- volume
- 101
- issue
- 12
- pages
- 1211 - 1216
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000310868300024
- pmid:22924869
- scopus:84869088895
- pmid:22924869
- ISSN
- 1651-2227
- DOI
- 10.1111/j.1651-2227.2012.02826.x
- language
- English
- LU publication?
- yes
- id
- 858d2059-cd44-4782-bc04-d4cb141c7033 (old id 3047137)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/22924869?dopt=Abstract
- date added to LUP
- 2016-04-01 13:53:17
- date last changed
- 2023-09-17 06:35:15
@article{858d2059-cd44-4782-bc04-d4cb141c7033,
abstract = {{Aim: <br/><br>
To characterize postnatal changes in serum IGF-I in relation to development of bronchopulmonary dysplasia (BPD) in very preterm infants. <br/><br>
<br/><br>
Methods: <br/><br>
Longitudinal study of 108 infants with mean (SD) gestational age 27.2 (2.2) weeks. Weekly serum samples of IGF-I were analyzed from birth until postmenstrual age 36 weeks. Multivariate models were developed to identify independent predictors of BPD. <br/><br>
<br/><br>
Results: <br/><br>
Postnatal mean IGF-I levels at postnatal day 3 to 21 were lower in infants with BPD compared to infants with no BPD (16 vs. 26 ug/L, p<0.001). Longitudinal postnatal change in IGF-I levels (IGF-I regression coefficient (β), postnatal days 3 to 21, was lower in infants with BPD compared to infants with no BPD (0.28 vs. 0.97, p=0.002) and mean IGF-I during postmenstrual age 30-33 weeks was lower in infants with BPD as compared to infants without BPD (22 vs. 29 ug/L, p<0.001). In a binomial multiple regression model lower gestational age, male gender and lower mean serum IGF-I levels during postnatal day 3-21 were the most predictive risk factors associated with BPD (r(2) =0.634, p<0.001). <br/><br>
<br/><br>
Conclusion: <br/><br>
Lower IGF-I concentrations during the first weeks after very preterm birth are associated with later development of BPD. © 2012 The Author(s)/Acta Paediatrica © 2012 Foundation Acta Paediatrica.}},
author = {{Löfqvist, Chatarina and Hellgren, Gunnel and Niklasson, Aimon and Engström, Eva and Ley, David and Pupp, Ingrid}},
issn = {{1651-2227}},
keywords = {{Bronchopulmonary dysplasia; Premature; infants; Insulin-like growth factor-1}},
language = {{eng}},
number = {{12}},
pages = {{1211--1216}},
publisher = {{Wiley-Blackwell}},
series = {{Acta paediatrica}},
title = {{Low Postnatal Serum IGF-I levels is Associated with Bronchopulmonary Dysplasia (BPD).}},
url = {{http://dx.doi.org/10.1111/j.1651-2227.2012.02826.x}},
doi = {{10.1111/j.1651-2227.2012.02826.x}},
volume = {{101}},
year = {{2012}},
}