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Low Postnatal Serum IGF-I levels is Associated with Bronchopulmonary Dysplasia (BPD).

Löfqvist, Chatarina; Hellgren, Gunnel; Niklasson, Aimon; Engström, Eva; Ley, David LU and Pupp, Ingrid LU (2012) In Acta paediatrica 101(12). p.1211-1216
Abstract
Aim:

To characterize postnatal changes in serum IGF-I in relation to development of bronchopulmonary dysplasia (BPD) in very preterm infants.



Methods:

Longitudinal study of 108 infants with mean (SD) gestational age 27.2 (2.2) weeks. Weekly serum samples of IGF-I were analyzed from birth until postmenstrual age 36 weeks. Multivariate models were developed to identify independent predictors of BPD.



Results:

Postnatal mean IGF-I levels at postnatal day 3 to 21 were lower in infants with BPD compared to infants with no BPD (16 vs. 26 ug/L, p<0.001). Longitudinal postnatal change in IGF-I levels (IGF-I regression coefficient (β), postnatal days 3 to 21, was lower in... (More)
Aim:

To characterize postnatal changes in serum IGF-I in relation to development of bronchopulmonary dysplasia (BPD) in very preterm infants.



Methods:

Longitudinal study of 108 infants with mean (SD) gestational age 27.2 (2.2) weeks. Weekly serum samples of IGF-I were analyzed from birth until postmenstrual age 36 weeks. Multivariate models were developed to identify independent predictors of BPD.



Results:

Postnatal mean IGF-I levels at postnatal day 3 to 21 were lower in infants with BPD compared to infants with no BPD (16 vs. 26 ug/L, p<0.001). Longitudinal postnatal change in IGF-I levels (IGF-I regression coefficient (β), postnatal days 3 to 21, was lower in infants with BPD compared to infants with no BPD (0.28 vs. 0.97, p=0.002) and mean IGF-I during postmenstrual age 30-33 weeks was lower in infants with BPD as compared to infants without BPD (22 vs. 29 ug/L, p<0.001). In a binomial multiple regression model lower gestational age, male gender and lower mean serum IGF-I levels during postnatal day 3-21 were the most predictive risk factors associated with BPD (r(2) =0.634, p<0.001).



Conclusion:

Lower IGF-I concentrations during the first weeks after very preterm birth are associated with later development of BPD. © 2012 The Author(s)/Acta Paediatrica © 2012 Foundation Acta Paediatrica. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Bronchopulmonary dysplasia, Premature, infants, Insulin-like growth factor-1
in
Acta paediatrica
volume
101
issue
12
pages
1211 - 1216
publisher
Wiley-Blackwell Publishing Ltd
external identifiers
  • wos:000310868300024
  • pmid:22924869
  • scopus:84869088895
ISSN
1651-2227
DOI
10.1111/j.1651-2227.2012.02826.x
language
English
LU publication?
yes
id
858d2059-cd44-4782-bc04-d4cb141c7033 (old id 3047137)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22924869?dopt=Abstract
date added to LUP
2012-09-05 21:24:03
date last changed
2017-10-01 04:14:13
@article{858d2059-cd44-4782-bc04-d4cb141c7033,
  abstract     = {Aim: <br/><br>
To characterize postnatal changes in serum IGF-I in relation to development of bronchopulmonary dysplasia (BPD) in very preterm infants. <br/><br>
<br/><br>
Methods: <br/><br>
Longitudinal study of 108 infants with mean (SD) gestational age 27.2 (2.2) weeks. Weekly serum samples of IGF-I were analyzed from birth until postmenstrual age 36 weeks. Multivariate models were developed to identify independent predictors of BPD. <br/><br>
<br/><br>
Results: <br/><br>
Postnatal mean IGF-I levels at postnatal day 3 to 21 were lower in infants with BPD compared to infants with no BPD (16 vs. 26 ug/L, p&lt;0.001). Longitudinal postnatal change in IGF-I levels (IGF-I regression coefficient (β), postnatal days 3 to 21, was lower in infants with BPD compared to infants with no BPD (0.28 vs. 0.97, p=0.002) and mean IGF-I during postmenstrual age 30-33 weeks was lower in infants with BPD as compared to infants without BPD (22 vs. 29 ug/L, p&lt;0.001). In a binomial multiple regression model lower gestational age, male gender and lower mean serum IGF-I levels during postnatal day 3-21 were the most predictive risk factors associated with BPD (r(2) =0.634, p&lt;0.001). <br/><br>
<br/><br>
Conclusion: <br/><br>
Lower IGF-I concentrations during the first weeks after very preterm birth are associated with later development of BPD. © 2012 The Author(s)/Acta Paediatrica © 2012 Foundation Acta Paediatrica.},
  author       = {Löfqvist, Chatarina and Hellgren, Gunnel and Niklasson, Aimon and Engström, Eva and Ley, David and Pupp, Ingrid},
  issn         = {1651-2227},
  keyword      = {Bronchopulmonary dysplasia,Premature,infants,Insulin-like growth factor-1},
  language     = {eng},
  number       = {12},
  pages        = {1211--1216},
  publisher    = {Wiley-Blackwell Publishing Ltd},
  series       = {Acta paediatrica},
  title        = {Low Postnatal Serum IGF-I levels is Associated with Bronchopulmonary Dysplasia (BPD).},
  url          = {http://dx.doi.org/10.1111/j.1651-2227.2012.02826.x},
  volume       = {101},
  year         = {2012},
}