Three cases of acute-onset bilateral photophobia
(2019) In Japanese Journal of Ophthalmology 63(2). p.172-180- Abstract
Purpose: To report the findings in 3 cases of bilateral negative electroretinograms (ERGs) with acute onset of photophobia. Study design: Retrospective case series. Methods: The medical charts of the 3 patients were reviewed. Results: A 43-year-old woman, a 68-year-old woman, and a 41-year-old woman were referred to Nagoya University Hospital. Their main symptom was bilateral acute photophobia. None of the patients had any systemic diseases or specific medical history. The decimal best-corrected visual acuity (> 0.8) and Humphrey visual fields (mean deviation > -3 dB) were relatively well preserved in all 3 patients. The optical coherence tomography (OCT) and fundus autofluorescence findings were essentially normal. Fluorescein... (More)
Purpose: To report the findings in 3 cases of bilateral negative electroretinograms (ERGs) with acute onset of photophobia. Study design: Retrospective case series. Methods: The medical charts of the 3 patients were reviewed. Results: A 43-year-old woman, a 68-year-old woman, and a 41-year-old woman were referred to Nagoya University Hospital. Their main symptom was bilateral acute photophobia. None of the patients had any systemic diseases or specific medical history. The decimal best-corrected visual acuity (> 0.8) and Humphrey visual fields (mean deviation > -3 dB) were relatively well preserved in all 3 patients. The optical coherence tomography (OCT) and fundus autofluorescence findings were essentially normal. Fluorescein angiography showed mild leakage in 1 patient but no abnormality in the other 2 patients. However, the ERGs of the 3 patients had the features of abnormal ERGs found in patients with incomplete congenital stationary night blindness (CSNB). Exome analyses found no pathogenic variants related to known CSNB-related genes. The symptoms and ERGs of the 3 patients have not progressed or recovered after a relatively long follow-up period. Conclusion: The ERG characteristics of 3 patients with bilateral photophobia were similar to those of incomplete CSNB, suggesting post-phototransductional abnormalities. The symptoms and genetic analyses indicated the possibility of an acquired condition rather than a hereditary retinal disease.
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- author
- Ueno, Shinji ; Inooka, Daiki ; Meinert, Monika LU ; Ito, Yasuki ; Tsunoda, Kazushige ; Fujinami, Kaoru ; Iwata, Takeshi ; Ohde, Hisao and Terasaki, Hiroko
- organization
- publishing date
- 2019-01-02
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Acquired retinal disease, Incomplete-type congenital stationary night blindness, Negative-type ERG, Post-phototransduction abnormality
- in
- Japanese Journal of Ophthalmology
- volume
- 63
- issue
- 2
- pages
- 172 - 180
- publisher
- Springer
- external identifiers
-
- scopus:85059585566
- pmid:30604114
- ISSN
- 0021-5155
- DOI
- 10.1007/s10384-018-00649-0
- language
- English
- LU publication?
- yes
- id
- 30502adc-59cb-4a6f-9d02-2183eb0dc9b4
- date added to LUP
- 2019-01-23 07:58:43
- date last changed
- 2024-04-01 18:20:19
@article{30502adc-59cb-4a6f-9d02-2183eb0dc9b4, abstract = {{<p>Purpose: To report the findings in 3 cases of bilateral negative electroretinograms (ERGs) with acute onset of photophobia. Study design: Retrospective case series. Methods: The medical charts of the 3 patients were reviewed. Results: A 43-year-old woman, a 68-year-old woman, and a 41-year-old woman were referred to Nagoya University Hospital. Their main symptom was bilateral acute photophobia. None of the patients had any systemic diseases or specific medical history. The decimal best-corrected visual acuity (> 0.8) and Humphrey visual fields (mean deviation > -3 dB) were relatively well preserved in all 3 patients. The optical coherence tomography (OCT) and fundus autofluorescence findings were essentially normal. Fluorescein angiography showed mild leakage in 1 patient but no abnormality in the other 2 patients. However, the ERGs of the 3 patients had the features of abnormal ERGs found in patients with incomplete congenital stationary night blindness (CSNB). Exome analyses found no pathogenic variants related to known CSNB-related genes. The symptoms and ERGs of the 3 patients have not progressed or recovered after a relatively long follow-up period. Conclusion: The ERG characteristics of 3 patients with bilateral photophobia were similar to those of incomplete CSNB, suggesting post-phototransductional abnormalities. The symptoms and genetic analyses indicated the possibility of an acquired condition rather than a hereditary retinal disease.</p>}}, author = {{Ueno, Shinji and Inooka, Daiki and Meinert, Monika and Ito, Yasuki and Tsunoda, Kazushige and Fujinami, Kaoru and Iwata, Takeshi and Ohde, Hisao and Terasaki, Hiroko}}, issn = {{0021-5155}}, keywords = {{Acquired retinal disease; Incomplete-type congenital stationary night blindness; Negative-type ERG; Post-phototransduction abnormality}}, language = {{eng}}, month = {{01}}, number = {{2}}, pages = {{172--180}}, publisher = {{Springer}}, series = {{Japanese Journal of Ophthalmology}}, title = {{Three cases of acute-onset bilateral photophobia}}, url = {{http://dx.doi.org/10.1007/s10384-018-00649-0}}, doi = {{10.1007/s10384-018-00649-0}}, volume = {{63}}, year = {{2019}}, }