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Basal superoxide as a sex-specific immune constraint

Tobler, Michael LU ; Healey, Mo; Wilson, Mark and Olsson, Mats (2011) In Biology Letters 7(6). p.906-908
Abstract
There is increasing evidence that reactive oxygen species (ROS), a group of unstable and highly reactive chemical molecules, play a key role in regulating and maintaining life-history trade-offs. Upregulation of ROS in association with immune activation is costly because it may result in an imbalance between pro- and antioxidants and, hence, oxidative damage. Previous research aimed at quantifying this cost has mostly focused on changes in the pro-/antioxidant balance subsequent to an immune response. Here, we test the hypothesis that systemic ROS may constrain immune activation. We show that systemic, pre-challenge superoxide (SO) levels are negatively related to the strength of the subsequent immune response towards the mitogen... (More)
There is increasing evidence that reactive oxygen species (ROS), a group of unstable and highly reactive chemical molecules, play a key role in regulating and maintaining life-history trade-offs. Upregulation of ROS in association with immune activation is costly because it may result in an imbalance between pro- and antioxidants and, hence, oxidative damage. Previous research aimed at quantifying this cost has mostly focused on changes in the pro-/antioxidant balance subsequent to an immune response. Here, we test the hypothesis that systemic ROS may constrain immune activation. We show that systemic, pre-challenge superoxide (SO) levels are negatively related to the strength of the subsequent immune response towards the mitogen phytohaemagglutinin in male, but not female painted dragon lizards (Ctenophorus pictus). We therefore suggest that systemic SO constrains immune activation in painted dragon males. We speculate that this may be due to sex-specific selection pressures on immune investment. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
reactive oxygen species, immunity, Ctenophorus pictus, phytohaemagglutinin
in
Biology Letters
volume
7
issue
6
pages
906 - 908
publisher
Royal Society
external identifiers
  • scopus:82455192861
ISSN
1744-9561
DOI
10.1098/rsbl.2011.0350
project
Costs of the immune system and maternal effects
language
English
LU publication?
yes
id
128164ae-0f7f-4012-9db1-8faacb7a01b6 (old id 3050478)
date added to LUP
2012-09-06 14:57:52
date last changed
2017-01-01 03:37:20
@article{128164ae-0f7f-4012-9db1-8faacb7a01b6,
  abstract     = {There is increasing evidence that reactive oxygen species (ROS), a group of unstable and highly reactive chemical molecules, play a key role in regulating and maintaining life-history trade-offs. Upregulation of ROS in association with immune activation is costly because it may result in an imbalance between pro- and antioxidants and, hence, oxidative damage. Previous research aimed at quantifying this cost has mostly focused on changes in the pro-/antioxidant balance subsequent to an immune response. Here, we test the hypothesis that systemic ROS may constrain immune activation. We show that systemic, pre-challenge superoxide (SO) levels are negatively related to the strength of the subsequent immune response towards the mitogen phytohaemagglutinin in male, but not female painted dragon lizards (Ctenophorus pictus). We therefore suggest that systemic SO constrains immune activation in painted dragon males. We speculate that this may be due to sex-specific selection pressures on immune investment.},
  author       = {Tobler, Michael and Healey, Mo and Wilson, Mark and Olsson, Mats},
  issn         = {1744-9561},
  keyword      = {reactive oxygen species,immunity,Ctenophorus pictus,phytohaemagglutinin},
  language     = {eng},
  number       = {6},
  pages        = {906--908},
  publisher    = {Royal Society},
  series       = {Biology Letters},
  title        = {Basal superoxide as a sex-specific immune constraint},
  url          = {http://dx.doi.org/10.1098/rsbl.2011.0350},
  volume       = {7},
  year         = {2011},
}