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Predictors of telomere content in dragon lizards

Ballen, Cissy; Healey, Mo; Wilson, Mark; Tobler, Michael LU and Olsson, Mats (2012) In Naturwissenschaften 99(8). p.661-664
Abstract
Telomeres shorten as a consequence of DNA

replication, in particular in cells with low production of

telomerase and perhaps in response to physiological stress

from exposure to reactive oxygen species, such as superoxide.

This process of telomere attrition is countered by innate

antioxidation, such as via the production of superoxide

dismutase. We studied the inheritance of telomere length

in the Australian painted dragon lizard (Ctenophorus pictus)

and the extent to which telomere length covaries with masscorrected

maternal reproductive investment, which reflects

the level of circulating yolk precursor and antioxidant,

vitellogenin. Our... (More)
Telomeres shorten as a consequence of DNA

replication, in particular in cells with low production of

telomerase and perhaps in response to physiological stress

from exposure to reactive oxygen species, such as superoxide.

This process of telomere attrition is countered by innate

antioxidation, such as via the production of superoxide

dismutase. We studied the inheritance of telomere length

in the Australian painted dragon lizard (Ctenophorus pictus)

and the extent to which telomere length covaries with masscorrected

maternal reproductive investment, which reflects

the level of circulating yolk precursor and antioxidant,

vitellogenin. Our predictors of offspring telomere length

explained 72 % of telomere variation (including interstitial

telomeres if such are present). Maternal telomere length and

reproductive investment were positively influencing offspring

telomere length in our analyses, whereas flow

cytometry-estimated superoxide level was negatively

impacting offspring telomere length. We suggest that the

effects of superoxide on hatchling telomere shortening may

be partly balanced by transgenerational effects of vitellogenin

antioxidation. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Lizard, Reactive oxygen species, Superoxide, Telomere, Vitellogenin
in
Naturwissenschaften
volume
99
issue
8
pages
661 - 664
publisher
Springer
external identifiers
  • wos:000307245100008
  • scopus:84866256294
ISSN
1432-1904
DOI
10.1007/s00114-012-0941-1
language
English
LU publication?
yes
id
f86948bd-7656-4c8a-a338-8ffc0b1b931a (old id 3050486)
date added to LUP
2012-09-06 14:09:53
date last changed
2017-04-23 03:22:34
@article{f86948bd-7656-4c8a-a338-8ffc0b1b931a,
  abstract     = {Telomeres shorten as a consequence of DNA<br/><br>
replication, in particular in cells with low production of<br/><br>
telomerase and perhaps in response to physiological stress<br/><br>
from exposure to reactive oxygen species, such as superoxide.<br/><br>
This process of telomere attrition is countered by innate<br/><br>
antioxidation, such as via the production of superoxide<br/><br>
dismutase. We studied the inheritance of telomere length<br/><br>
in the Australian painted dragon lizard (Ctenophorus pictus)<br/><br>
and the extent to which telomere length covaries with masscorrected<br/><br>
maternal reproductive investment, which reflects<br/><br>
the level of circulating yolk precursor and antioxidant,<br/><br>
vitellogenin. Our predictors of offspring telomere length<br/><br>
explained 72 % of telomere variation (including interstitial<br/><br>
telomeres if such are present). Maternal telomere length and<br/><br>
reproductive investment were positively influencing offspring<br/><br>
telomere length in our analyses, whereas flow<br/><br>
cytometry-estimated superoxide level was negatively<br/><br>
impacting offspring telomere length. We suggest that the<br/><br>
effects of superoxide on hatchling telomere shortening may<br/><br>
be partly balanced by transgenerational effects of vitellogenin<br/><br>
antioxidation.},
  author       = {Ballen, Cissy and Healey, Mo and Wilson, Mark and Tobler, Michael and Olsson, Mats},
  issn         = {1432-1904},
  keyword      = {Lizard,Reactive oxygen species,Superoxide,Telomere,Vitellogenin},
  language     = {eng},
  number       = {8},
  pages        = {661--664},
  publisher    = {Springer},
  series       = {Naturwissenschaften},
  title        = {Predictors of telomere content in dragon lizards},
  url          = {http://dx.doi.org/10.1007/s00114-012-0941-1},
  volume       = {99},
  year         = {2012},
}