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Cytogenetic abnormalities and clonal evolution in an adult hepatoblastoma

Parada, Luis Antonio; Bardi, Georgia; Hallén, Magnus LU ; Hagerstrand, Inga; Tranberg, Karl-Göran LU ; Mitelman, Felix LU and Johansson, Bertil LU (1997) In American Journal of Surgical Pathology 21(11). p.6-1381
Abstract
Hepatoblastomas usually occur in children < 3 years of age, and only occasional adult cases have been described. To date, 20 cytogenetically abnormal childhood hepatoblastomas have been reported. Karyotypic investigations have shown that most hepatoblastomas are diploid or hyperdiploid, often displaying trisomies for chromosomes 2 and 20. We have cytogenetically investigated an adult hepatoblastoma for which no previous karyotypic data exist. A hypertriploid stemline with multiple numerical and structural chromosomal aberrations, including +2 and +20, was found. In addition, the tumor displayed extensive clonal evolution with 11 subclones. Although the tumor thus displayed some chromosomal abnormalities commonly observed in childhood... (More)
Hepatoblastomas usually occur in children < 3 years of age, and only occasional adult cases have been described. To date, 20 cytogenetically abnormal childhood hepatoblastomas have been reported. Karyotypic investigations have shown that most hepatoblastomas are diploid or hyperdiploid, often displaying trisomies for chromosomes 2 and 20. We have cytogenetically investigated an adult hepatoblastoma for which no previous karyotypic data exist. A hypertriploid stemline with multiple numerical and structural chromosomal aberrations, including +2 and +20, was found. In addition, the tumor displayed extensive clonal evolution with 11 subclones. Although the tumor thus displayed some chromosomal abnormalities commonly observed in childhood tumors, providing further support for the importance of these abnormalities in the development of hepatoblastoma, the level of genomic complexity seen in the present case has never been described in childhood hepatoblastomas and may suggest a different etiology or pathogenesis. (Less)
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Contribution to journal
publication status
published
subject
keywords
Keratins/analysis, Karyotyping, Immunohistochemistry, Humans, Hepatoblastoma/chemistry/ genetics/ pathology, Pair 1, Human, Chromosomes, Chromosome Disorders, Aged, Chromosome Aberrations, Liver Neoplasms/chemistry/ genetics/ pathology, Male, Tumor Markers, Biological/analysis
in
American Journal of Surgical Pathology
volume
21
issue
11
pages
6 - 1381
publisher
Lippincott Williams & Wilkins
external identifiers
  • scopus:0030782369
ISSN
1532-0979
language
English
LU publication?
yes
id
81a51c41-39de-4caa-9c83-162860b37e71 (old id 3052287)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/9351578
http://journals.lww.com/ajsp/pages/articleviewer.aspx?year=1997&issue=11000&article=00015&type=abstract
date added to LUP
2013-05-07 14:18:03
date last changed
2017-04-30 15:34:19
@article{81a51c41-39de-4caa-9c83-162860b37e71,
  abstract     = {Hepatoblastomas usually occur in children &lt; 3 years of age, and only occasional adult cases have been described. To date, 20 cytogenetically abnormal childhood hepatoblastomas have been reported. Karyotypic investigations have shown that most hepatoblastomas are diploid or hyperdiploid, often displaying trisomies for chromosomes 2 and 20. We have cytogenetically investigated an adult hepatoblastoma for which no previous karyotypic data exist. A hypertriploid stemline with multiple numerical and structural chromosomal aberrations, including +2 and +20, was found. In addition, the tumor displayed extensive clonal evolution with 11 subclones. Although the tumor thus displayed some chromosomal abnormalities commonly observed in childhood tumors, providing further support for the importance of these abnormalities in the development of hepatoblastoma, the level of genomic complexity seen in the present case has never been described in childhood hepatoblastomas and may suggest a different etiology or pathogenesis.},
  author       = {Parada, Luis Antonio and Bardi, Georgia and Hallén, Magnus and Hagerstrand, Inga and Tranberg, Karl-Göran and Mitelman, Felix and Johansson, Bertil},
  issn         = {1532-0979},
  keyword      = {Keratins/analysis,Karyotyping,Immunohistochemistry,Humans,Hepatoblastoma/chemistry/ genetics/ pathology,Pair 1,Human,Chromosomes,Chromosome Disorders,Aged,Chromosome Aberrations,Liver Neoplasms/chemistry/ genetics/ pathology,Male,Tumor Markers,Biological/analysis},
  language     = {eng},
  number       = {11},
  pages        = {6--1381},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {American Journal of Surgical Pathology},
  title        = {Cytogenetic abnormalities and clonal evolution in an adult hepatoblastoma},
  volume       = {21},
  year         = {1997},
}